scholarly journals CXCL12 in astrocytes contributes to bone cancer pain through CXCR4-mediated neuronal sensitization and glial activation in rat spinal cord

2014 ◽  
Vol 11 (1) ◽  
pp. 75 ◽  
Author(s):  
Wen Shen ◽  
Xue-Ming Hu ◽  
Yan-Nan Liu ◽  
Yuan Han ◽  
Li-Ping Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Bone Cancer ◽  
Glial Activation ◽  
Bone Cancer Pain ◽  
Rat Spinal Cord

scholarly journals Simultaneous inhibition of NMDA and mGlu1/5 receptors bylevo-corydalmine in rat spinal cord attenuates bone cancer pain

2017 ◽  
Vol 141 (4) ◽  
pp. 805-815 ◽  
Author(s):  
Wen-Ling Dai ◽  
Bing Yan ◽  
Nan Jiang ◽  
Juan-Juan Wu ◽  
Xiu-Feng Liu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Rat Spinal Cord ◽  
Simultaneous Inhibition

scholarly journals Neuroligins Facilitate The Development of Bone Cancer Pain via Regulating Synaptic Transmission

2021 ◽  
Author(s):  
Xianqiao Xie ◽  
Yang Li ◽  
Shanchun Su ◽  
Xiaohui Li ◽  
Xueqin Xu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Chronic Pain ◽  
Cancer Pain ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Bone Cancer ◽  
Bone Cancer Pain ◽  
Rat Spinal Cord ◽  
Spinal Dorsal

Abstract Background The underlying mechanism of chronic pain involves the plasticity in synaptic receptors and neurotransmitters. This study aimed to investigate potential roles of neuroligins (NLs) within the spinal dorsal horn of rats in a newly established bone cancer pain (BCP) model. Methods Using our rat BCP model, we assessed pain hypersensitivity over time. Quantitative real-time polymerase chain reaction and Western blot analysis were performed to investigate NL expression, and NLs were overexpressed in the rat spinal cord using lentiviral vectors. Immunofluorescence staining and whole-cell patch-clamp recordings were deployed to investigate the role of NLs in the development of BCP. Results We observed reduced expression levels of NL1 and NL2, but not NL3, within the rat spinal cord, which were found to be associated with and essential for the development of BCP in our model. Accordingly, NL1 or NL2 overexpression in the spinal cord alleviated mechanical hypersensitivity of rats. Electrophysiological experiments indicated that NL1 and NL2 are involved in BCP via regulating γ-aminobutyric acid-ergic interneuronal synapses and the activity of glutamatergic interneuronal synapses, respectively. Conclusions Our observations unravel the role of NLs in cancer-related chronic pain and further suggest that inhibitory mechanisms are central features of BCP in the spinal dorsal horn. These results provide a new perspective and basis for subsequent studies elucidating the onset and progression of BCP.

scholarly journals Levo-Tetrahydropalmatine Attenuates Bone Cancer Pain by Inhibiting Microglial Cells Activation

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Mao-yin Zhang ◽  
Yue-peng Liu ◽  
Lian-yi Zhang ◽  
Dong-mei Yue ◽  
Dun-yi Qi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Mechanical Allodynia ◽  
Thermal Hyperalgesia ◽  
Bone Cancer ◽  
Microglial Cells ◽  
Bone Cancer Pain ◽  
Enzyme Linked Immunosorbent Assay ◽  
Analgesic Effects ◽  
Before And After

Objective. The present study is to investigate the analgesic roles of L-THP in rats with bone cancer pain caused by tumor cell implantation (TCI).Methods. Thermal hyperalgesia and mechanical allodynia were measured at different time points before and after operation. L-THP (20, 40, and 60 mg/kg) were administrated intragastrically at early phase of postoperation (before pain appearance) and later phase of postoperation (after pain appearance), respectively. The concentrations of TNF-α, IL-1β, and IL-18 in spinal cord were measured by enzyme-linked immunosorbent assay. Western blot was used to test the activation of astrocytes and microglial cells in spinal cord after TCI treatment.Results. TCI treatment induced significant thermal hyperalgesia and mechanical allodynia. Administration of L-THP at high doses significantly prevented and/or reversed bone cancer-related pain behaviors. Besides, TCI-induced activation of microglial cells and the increased levels of TNF-αand IL-18 were inhibited by L-THP administration. However, L-THP failed to affect TCI-induced astrocytes activation and IL-1βincrease.Conclusion. This study suggests the possible clinical utility of L-THP in the treatment of bone cancer pain. The analgesic effects of L-THP on bone cancer pain maybe underlying the inhibition of microglial cells activation and proinflammatory cytokines increase.

scholarly journals Promotion of bone cancer pain development by decorin is accompanied by modification of excitatory synaptic molecules in the spinal cord

2019 ◽  
Vol 15 ◽  
pp. 174480691986425 ◽  
Author(s):  
Huan Wang ◽  
Xiaohui Li ◽  
Xianqiao Xie ◽  
Haiwen Zhao ◽  
Yan Gao ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Cancer Pain ◽  
Bone Cancer ◽  
Bone Cancer Pain

Spinal glial activation in a new rat model of bone cancer pain produced by prostate cancer cell inoculation of the tibia

Pain ◽  
2005 ◽  
Vol 118 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Rui-Xin Zhang ◽  
Bing Liu ◽  
Linbo Wang ◽  
Ke Ren ◽  
Jian-Tian Qiao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Pain ◽  
Cancer Cell ◽  
Rat Model ◽  
Prostate Cancer Cell ◽  
Bone Cancer ◽  
Glial Activation ◽  
Bone Cancer Pain ◽  
Cell Inoculation
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