Surgical management of low grade isthmic spondylolisthesis; a randomized controlled study of the surgical fixation with and without reduction

Background: Medical method of termination of pregnancy is a very effective method when used as per recommended regimen and under proper supervision. Self-administration of these drugs has become a very common practice these days, resulting in incomplete abortion because of improper use. Traditionally surgical curettage has been the preferred mode of treatment for these cases but is associated with very high complication rates. Expectant management of incomplete abortion has been recently adopted as a better method of management of incomplete abortions worldwide. Present study compares expectant management with surgical curettage in cases of incomplete abortions caused by self medication.Methods: It was one-year prospective randomized controlled study. Total of 220 patients were recruited for the study out of which 103 were randomized to undergo expectant management while 117 to undergo surgical curettage. Results were compared using chi square test..Results: Success rate of expectant and surgical management was found to be 82% and 95% respectively. Complication rate was found to be comparable in both the group while acceptability of expectant management was found to be much higher in expectant group. However, significantly more unplanned admissions and unplanned surgical curettage occurred after expectant management than surgical management.Conclusions: Expectant management is a safe and efficacious option in carefully selected cases. If used properly it can avoid complications associated with surgical management and therefore should be utilized whenever suitable.

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Management of clinically diagnosed subacute rhinosinusitis in children under the age of two years: a randomized, controlled study

The Journal of Laryngology & Otology ◽

10.1017/s0022215106000776 ◽

2006 ◽

Vol 120 (10) ◽

pp. 845-848 ◽

Cited By ~ 3

Author(s):

D M El-Hennawi ◽

A S Abou-Halawa ◽

S R Zaher

Keyword(s):

Nasal Obstruction ◽

Study Design ◽

Randomized Controlled Study ◽

Controlled Study ◽

Nasal Discharge ◽

Low Grade ◽

Randomized Controlled ◽

Persistent Cough ◽

Amoxicillin Clavulanate

Background: In children, a diagnosis of rhinosinusitis is usually made on clinical grounds. Subacute rhinosinusitis (SRS) may be the cause of persistent cough, low-grade fever, snoring, ear problems and difficult feeding in children under the age of two years.Objective: To compare the efficacy of culture-based antibiotics and empiric amoxicillin–clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.Study design: Randomized, controlled study.Population: Sixty children with persistent nasal discharge and nasal obstruction (and other related symptoms) for 30–90 days.Methods: Group one (n = 30) received culture-based antibiotics and group two (n = 30) were treated empirically with 40 mg/kg/day of amoxicillin–clavulanate. Treatment was continued for two weeks.Results: At the end of the three-week follow-up period, statistically significant greater improvements in nasal obstruction (p = 0.037) and nasal discharge (p = 0.003) were seen in group one compared with group two.Conclusion: culture-based antibiotics were more efficacious than empiric amoxicillin–clavulanate (40 mg/kg/day) in treating SRS in children under the age of two years.

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The long-term effect of posterolateral fusion in adult isthmic spondylolisthesis: a randomized controlled study

The Spine Journal ◽

10.1016/j.spinee.2004.05.249 ◽

2005 ◽

Vol 5 (1) ◽

pp. 36-44 ◽

Cited By ~ 89

Author(s):

Per Ekman ◽

Hans Möller ◽

Rune Hedlund

Keyword(s):

Term Effect ◽

Posterolateral Fusion ◽

Randomized Controlled Study ◽

Controlled Study ◽

Isthmic Spondylolisthesis ◽

Randomized Controlled ◽

Long Term Effect

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Multicenter, open-end, randomized controlled study using P53 gene recombinant adenovirus injection (rAd-p53) combined with chemotherapy for orofacial carcinoma (OFC): Phase IV clinical trial—Progress report and conclusion.

Journal of Clinical Oncology ◽

10.1200/jco.2013.31.15_suppl.6080 ◽

2013 ◽

Vol 31 (15_suppl) ◽

pp. 6080-6080

Author(s):

Maolin Yang ◽

Longjiang Li

Keyword(s):

Recombinant Adenovirus ◽

Combined Treatment ◽

P53 Gene ◽

Randomized Controlled Study ◽

Controlled Study ◽

Control Group ◽

Low Grade ◽

Randomized Controlled ◽

Long Term Follow Up ◽

Phase Iv

6080 Background: The gene therapy product (Gendicine, rAd-p53) had pre-market studies done around 1998 indicated its efficacy in the treatment of squamous cell nasopharyngeal carcinoma in multi-modality treatment regimen. Gendicine has been used successfully in treating over 40 cancer types since then. With the advancement in optimization of combined treatment methods over the years, there was a need for a medium term efficacy study. This report summarizes our phase IV study. Methods: Patient selection, intervention and allocation were done according to GCP and supported by statistical analysis. Orofacial cancer (OFC) patients of advanced stages (III/IV) from multiple hospitals (n=30) in China were recruited for this open-end, randomized, controlled study (2009.7--2012.06). The 2 groups were rAd-p53+chemotherapy (GT+CT) (n=743) and CT alone (n=232). Patient exclusion rate were 20.81% (n=128) and 13.9% (n=28) respectively. Virus particles were delivered intra-tumorally at a dose of 109 (tumor cell/cm2 tumor area) x area x100 (virus multiplicity of infection, MOI), every 3d totally 10 times on d 1-28 inclusive. In synchrony with GT, 5-fluorouracil (5-FU, 250 mg/m2/d), on d 7-11 and d 25-29 along with carbocisplatin (KP, 400 mg/m2/d, i.v.), and with methotrexate (MTX, 50mg/m2 /d) on d 7, 14, 25, 32 were administered. The control group received 5-FU, KP and MTX. Results: For advanced OFC treated with GT+CT, the efficacy and QoL were significantly (p<=0.001) improved, the result was in accordance with our phase II/ III studies. Conclusions: This study proved rAd-p53 when used as an adjunct is safe and efficacious. The side-effect was mostly self-limiting low-grade to mild fever. The combined treatment modality had complete remission (CR) improved by 21.38%, relief ratio (RR) by 11.53% and clinical benefit ratio by 20.82% over GT-CT. Long-term follow-up will be continued.

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