scholarly journals A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

2008 ◽  
Vol 1 (1) ◽  
Author(s):  
Richard Abraham ◽  
Valentina Moskvina ◽  
Rebecca Sims ◽  
Paul Hollingworth ◽  
Angharad Morgan ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Late Onset ◽  
Genome Wide Association ◽  
Dna Pooling ◽  
Genome Wide ◽  
A Genome

P3-196: A genome-wide association study for late-onset Alzheimer's disease using DNA pooling

2008 ◽  
Vol 4 ◽  
pp. T578-T578 ◽  
Author(s):  
Richard Abraham ◽  
Lyudmila Georgieva ◽  
Rebecca Sims ◽  
Angharad Morgan ◽  
Paul Hollingworth ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Late Onset ◽  
Genome Wide Association ◽  
Dna Pooling ◽  
Genome Wide ◽  
A Genome

A genome-wide association study of late-onset Alzheimer’s disease in a Japanese population

2015 ◽  
Vol 25 (4) ◽  
pp. 139-146 ◽  
Author(s):  
Atsushi Hirano ◽  
Tomoyuki Ohara ◽  
Atsushi Takahashi ◽  
Masayuki Aoki ◽  
Yuta Fuyuno ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Japanese Population ◽  
Genome Wide Association Study ◽  
Late Onset ◽  
Genome Wide Association ◽  
Genome Wide ◽  
A Genome

scholarly journals Potential Novel Genes for Late-Onset Alzheimer’s Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study

2021 ◽  
pp. 1-10
Author(s):  
Sarang Kang ◽  
Jungsoo Gim ◽  
Jiwoon Lee ◽  
Tamil Iniyan Gunasekaran ◽  
Kyu Yeong Choi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Association Study ◽  
Genome Wide Association Study ◽  
Late Onset ◽  
East Asian ◽  
Genome Wide Association ◽  
Japanese Cohort ◽  
Genome Wide ◽  
A Genome

The present study reports two novel genome-wide significant loci for late-onset Alzheimer’s disease (LOAD) identified from APOE ε4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer’s disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer’ and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: LRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.

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