scholarly journals Cuticle thickening associated with pyrethroid resistance in the major malaria vector Anopheles funestus

2010 ◽  
Vol 3 (1) ◽  
pp. 67 ◽  
Author(s):  
O R Wood ◽  
S Hanrahan ◽  
M Coetzee ◽  
L L Koekemoer ◽  
B D Brooke
Keyword(s):  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Major Malaria Vector

scholarly journals Two duplicated P450 genes are associated with pyrethroid resistance in Anopheles funestus, a major malaria vector

2008 ◽  
Vol 19 (3) ◽  
pp. 452-459 ◽  
Author(s):  
C. S. Wondji ◽  
H. Irving ◽  
J. Morgan ◽  
N. F. Lobo ◽  
F. H. Collins ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Major Malaria Vector

Inheritance of pyrethroid resistance in the major malaria vector in southern Africa,Anopheles funestus

2008 ◽  
Vol 102 (3) ◽  
pp. 275-281 ◽  
Author(s):  
P. N. Okoye ◽  
B. D. Brooke ◽  
L. L. Koekemoer ◽  
R. H. Hunt ◽  
M. Coetzee
Keyword(s):  
Malaria Vector ◽  
Southern Africa ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Major Malaria Vector

scholarly journals Pyrethroid Resistance in the Major Malaria Vector Anopheles funestus is Exacerbated by Overexpression and Overactivity of the P450 CYP6AA1 Across Africa

Genes ◽  
2018 ◽  
Vol 9 (3) ◽  
pp. 140 ◽  
Author(s):  
Sulaiman Ibrahim ◽  
Nathalie Amvongo-Adjia ◽  
Murielle Wondji ◽  
Helen Irving ◽  
Jacob Riveron ◽  
...  
Keyword(s):  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Major Malaria Vector

The cytochrome P450 CYP325A is a major driver of pyrethroid resistance in the major malaria vector Anopheles funestus in Central Africa

2021 ◽  
Vol 138 ◽  
pp. 103647 ◽  
Author(s):  
Amelie N.R. Wamba ◽  
Sulaiman S. Ibrahim ◽  
Michael O. Kusimo ◽  
Abdullahi Muhammad ◽  
Leon M.J. Mugenzi ◽  
...  
Keyword(s):  
Cytochrome P450 ◽  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Central Africa ◽  
Major Malaria Vector

scholarly journals Widespread Pyrethroid and DDT Resistance in the Major Malaria Vector Anopheles funestus in East Africa Is Driven by Metabolic Resistance Mechanisms

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110058 ◽  
Author(s):  
Charles Mulamba ◽  
Jacob M. Riveron ◽  
Sulaiman S. Ibrahim ◽  
Helen Irving ◽  
Kayla G. Barnes ◽  
...  
Keyword(s):  
East Africa ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
Resistance Mechanisms ◽  
Metabolic Resistance ◽  
Ddt Resistance ◽  
Major Malaria Vector

A New Species Concealed by Anopheles funestus Giles, a Major Malaria Vector in Africa

2009 ◽  
Vol 81 (3) ◽  
pp. 510-515 ◽  
Author(s):  
Belinda L. Spillings ◽  
Richard H. Hunt ◽  
John Chiphwanya ◽  
Basil D. Brooke ◽  
Maureen Coetzee ◽  
...  
Keyword(s):  
New Species ◽  
Malaria Vector ◽  
Anopheles Funestus ◽  
A New Species ◽  
Major Malaria Vector

scholarly journals Evaluating the Evidence from Molecular Structure and Population Studies for Cross-Resistance to the Pyrethroids Used in Malaria Vector Control

2020 ◽  
Author(s):  
Catherine L. Moyes ◽  
Rosemary S. Lees ◽  
Cristina Yunta ◽  
Kyle J. Walker ◽  
Kay Hemmings ◽  
...  
Keyword(s):  
Binding Affinity ◽  
Malaria Vector ◽  
Pyrethroid Resistance ◽  
Anopheles Funestus ◽  
Malaria Vectors ◽  
Cross Resistance ◽  
Malaria Vector Control ◽  
Insecticide Treated Nets ◽  
The Common ◽  
The Impact

Abstract The primary malaria control intervention in high burden countries is the deployment of long-lasting insecticide-treated nets (LLINs) treated with pyrethroids, alone or in combination with a second active ingredient or synergist. It is essential to understand whether the impact of pyrethroid resistance can be mitigated by switching between different pyrethroids or whether cross-resistance precludes this. Structural diversity within the pyrethroids could mean some compounds are better able to counteract the resistance mechanisms that have evolved in malaria vectors. Here we consider variation in vulnerability to the P450 enzymes that confer metabolic pyrethroid resistance in Anopheles gambiae s.l. and Anopheles funestus. We assess the relationships among pyrethroids in terms of their binding affinity to key P450s and the percent dep­letion by these P450s, in order to identify which pyrethroids diverge from the others. We then investigate whether these same pyrethroids also diverge from the others in terms of resistance in vector populations. We found that etofenprox, which lacks the common structural moiety of other pyrethroids, potentially diverges from the commonly deployed pyrethroids in terms of P450 binding affinity and resistance in malaria vector populations, but not depletion by the P450s tested. These results are supplemented by an analysis of resistance to the same pyrethroids in Aedes aegypti populations, which also found etofenprox diverges from the other pyrethroids in terms of resistance in wild populations. In addition, we found that bifenthrin, which also lacks the common structural moiety of most pyrethroids, diverges from the commonly deployed pyrethroids in terms of P450 binding affinity and depletion by P450s. However, resistance to bifenthrin in vector populations is largely untested. The prevalence of resistance to the pyrethroids α-cypermethrin, cyfluthrin, deltamethrin, λ-cyhalothrin, and permethrin was correlated across malaria vector populations and switching between these compounds as a tool to mitigate against pyrethroid resistance is not advised without strong evidence supporting a true difference in resistance.

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