In vitro screening of antifungal activity of marine sponge extracts against five phytopathogenic fungi

Vanillin oxime- N-O-alkanoates were synthesized following reaction of vanillin with hydroxylamine hydrochloride, followed by reaction of the resultant oxime with acyl chlorides. The structures of the compounds were confirmed by IR, 1H, 13C NMR and mass spectral data. The test compounds were evaluated for their in vitro antifungal activity against three phytopathogenic fungi Macrophomina phaseolina, Rhizoctonia solani and Sclerotium rolfsii by the poisoned food technique. The moderate antifungal activity of vanillin was slightly increased following its conversion to vanillin oxime, but significantly increased after conversion of the oxime to oxime- N-O-alkanoates. While vanillin oxime- N-O-dodecanoate with an EC50 value 73.1 μg/mL was most active against M. phaseolina, vanillin oxime- N-O-nonanoate with EC50 of value 66.7 μg/mL was most active against R. solani. The activity increased with increases in the acyl chain length and was maximal with an acyl chain length of nine carbons.

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Synthesis and Antifungal Activities of Some 2,6-Bis-(Un)Substituted Phenoxymethylpyridines

Zeitschrift für Naturforschung C ◽

10.1515/znc-2010-7-802 ◽

2010 ◽

Vol 65 (7-8) ◽

pp. 433-436

Author(s):

Hui Xu ◽

Huan Qu

Keyword(s):

Antifungal Activity ◽

Fusarium Oxysporum ◽

Fusarium Graminearum ◽

Broad Spectrum ◽

Alternaria Alternata ◽

Phytopathogenic Fungi ◽

Alternaria Brassicae ◽

Antifungal Activities

Several 2,6-bis-(un)substituted phenoxymethylpyridines were synthesized and evaluated in vitro against Fusarium graminearum, Helminthosporium sorokinianum, Alternaria brassicae, Alternaria alternata, and Fusarium oxysporum f. sp. vasinfectum. Among all derivatives, compound 3 a exhibited a broad-spectrum antifungal activity against the five phytopathogenic fungi.

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In vitro Antifungal Activity of Plant Extracts, Hydrolates and Essential Oils of Some Medicinal Plants and Control of Cucumber Anthracnose

European Journal of Medicinal Plants ◽

10.9734/ejmp/2019/v28i430139 ◽

2019 ◽

pp. 1-9

Author(s):

Amanda P. Mattos ◽

Fabricio P. Povh ◽

Bruna B. Rissato ◽

Vítor V. Schwan ◽

Kátia R. F. Schwan-Estrada

Keyword(s):

Antifungal Activity ◽

Medicinal Plants ◽

Curcuma Longa ◽

Sclerotium Rolfsii ◽

Phytopathogenic Fungi ◽

In Vivo Test ◽

Activity Effect ◽

In Vitro Antifungal Activity

Aims: This study is aimed to evaluate the in vitro antifungal activity effect of the crude aqueous extract (CAE), hydrolate (HY) and essential oil (EO) of Corymbia citriodora, Cymbopogon citratus, Cymbopogon flexuosus and Curcuma longa against the phytopathogenic fungi Alternaria steviae, Botryosphaeria dothidea, Colletotrichum gloeosporioides and Sclerotium rolfsii, and assess, in situ, the effectiveness of CAE of medicinal plants in reducing the severity of the cucumber anthracnose. Methodology: The EOs and HYs were obtained by hydrodistillation. The CAEs were prepared by the turbolysis method. Mycelial growth of the fungi was measured daily, by the diametrically opposite method. In the in vivo test, the CAEs were sprayed on the cotyledon leaves of healthy cucumber plants with three days after were inoculated with C. lagenarium. The severity of assessment of the disease was based on a scale of notes. Results: The medicinal plants studied showed antifungal activity against all or almost all pathogens. In general, treatment with CAE and HY of C. longa revealed the highest inhibition against the fungi tested. With the exception of the EO of C. longa, the other EOs showed total inhibition against all the fungi and in all the concentrations tested. Compared to control, in in vivo assays CAE of C. citratus presents a potential for control of cucumber anthracnose reducing the severity of the disease. Conclusion: The medicinal plants studied produce compounds associated with antimicrobial activity.

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Facile synthesis and antifungal activity of dithiocarbamate derivatives bearing an amide moiety

Journal of the Serbian Chemical Society ◽

10.2298/jsc150114047l ◽

2015 ◽

Vol 80 (11) ◽

pp. 1367-1374 ◽

Cited By ~ 3

Author(s):

Yu-Wen Li ◽

Shu-Tao Li

Keyword(s):

Antifungal Activity ◽

Fusarium Solani ◽

High Resolution Mass Spectrometry ◽

Alternaria Solani ◽

Phytopathogenic Fungi ◽

Gibberella Zeae ◽

Significant Activity ◽

Facile Synthesis ◽

Dithiocarbamate Derivatives

A series of novel dithiocarbamate derivatives bearing amide moiety 3a-3i and 4a-4i were synthesized by a facile method, and the structures of these derivatives were confirmed by 1H NMR, 13C NMR, elemental analysis and high-resolution mass spectrometry (HRMS). Their antifungal activity against five phytopathogenic fungi were evaluated, and the results showed that most of the target compounds displayed low antifungal activity in vitro against Gibberella zeae, Cytospora sp., Collectotrichum gloeosporioides, Alternaria solani, and Fusarium solani at concentration of 100 mg/L. Compound 4f and 4g exhibited significant activity against Alternaria solani and Collectotrichum gloeosporioides, respectively.

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Antifungal Activity In Vitro and In Vivo of Mesquite Extract (Prosopis glandulosa) Against Phytopathogenic Fungi

Indian Journal of Microbiology ◽

10.1007/s12088-020-00906-2 ◽

2020 ◽

Author(s):

Arely Nohemí López-Anchondo ◽

Daniel López-de la Cruz ◽

Edgar Gutiérrez-Reyes ◽

José Cristobal Castañeda-Ramírez ◽

Norma Margarita De la Fuente-Salcido

Keyword(s):

Antifungal Activity ◽

Phytopathogenic Fungi ◽

Prosopis Glandulosa

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Synthesis and Bio-Evaluation of Natural Butenolides-Acrylate Conjugates

Molecules ◽

10.3390/molecules24071304 ◽

2019 ◽

Vol 24 (7) ◽

pp. 1304 ◽

Cited By ~ 1

Author(s):

Longzhu Bao ◽

Shuangshuang Wang ◽

Di Song ◽

Jingjing Wang ◽

Xiufang Cao ◽

...

Keyword(s):

Mass Spectrometry ◽

Antifungal Activity ◽

13C Nmr ◽

Pathogenic Fungi ◽

Phytopathogenic Fungi ◽

Gibberella Zeae ◽

Ionization Mass ◽

Activity Screening ◽

In Vitro Antifungal Activity

A series of novel 3-aryl-4-hydroxy-2(5H) furanone-acrylate hybrids were designed and synthesized based on the natural butenolides and acrylates scaffolds. The structures of the prepared compounds were characterized by 1H-NMR, 13C-NMR and electrospray ionization mass spectrometry (ESI-MS), and the bioactivity of the target compounds against twelve phytopathogenic fungi was investigated. The preliminary in vitro antifungal activity screening showed that most of the target compounds had moderate inhibition on various pathogenic fungi at the concentration of 100 mg·L−1, and presented broad-spectrum antifungal activities. Further studies also indicated that compounds 7e and 7k still showed some inhibitory activity against Pestallozzia theae, Sclerotinia sclerotiorum and Gibberella zeae on rape plants at lower concentrations, which could be optimized as a secondary lead for further research.

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