Effects of dronabinol on breathlessness and exercise capacity in chronic lung disease

2022 ◽  
Author(s):  
Abdul Zaid ◽  
N. Lennard Specht
Keyword(s):  
Lung Disease ◽  
Exercise Capacity ◽  
Chronic Lung Disease

scholarly journals Minimal versus specialist equipment in the delivery of pulmonary rehabilitation: protocol for a non-inferiority randomised controlled trial

BMJ Open ◽  
2021 ◽  
Vol 11 (10) ◽  
pp. e047524
Author(s):  
Claire M Nolan ◽  
Jessica A Walsh ◽  
Suhani Patel ◽  
Ruth E Barker ◽  
Oliver Polgar ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Lung Disease ◽  
Exercise Capacity ◽  
Chronic Lung Disease ◽  
Pulmonary Rehabilitation ◽  
Randomised Trial ◽  
Global Rating ◽  
Process Data ◽  
Exercise Equipment

IntroductionPulmonary rehabilitation (PR), an exercise and education programme for people with chronic lung disease, aims to improve exercise capacity, breathlessness and quality of life. Most evidence to support PR is from trials that use specialist exercise equipment, for example, treadmills (PR-gym). However, a significant proportion of programmes do not have access to specialist equipment with training completed with minimal exercise equipment (PR-min). There is a paucity of robust literature examining the efficacy of supervised, centre-based PR-min. We aim to determine whether an 8-week supervised, centre-based PR-min programme is non-inferior to a standard 8-week supervised, centre-based PR-gym programme in terms of exercise capacity and health outcomes for patients with chronic lung disease.Methods and analysisParallel, two-group, assessor-blinded and statistician-blinded, non-inferiority randomised trial. 436 participants will be randomised using minimisation at the individual level with a 1:1 allocation to PR-min (intervention) or PR-gym (control). Assessment will take place pre-PR (visit 1), post-PR (visit 2) and 12 months following visit 1 (visit 3). Exercise capacity (incremental shuttle walk test), dyspnoea (Chronic Respiratory Questionnaire (CRQ)-Dyspnoea), health-related quality of life (CRQ), frailty (Short Physical Performance Battery), muscle strength (isometric quadriceps maximum voluntary contraction), patient satisfaction (Global Rating of Change Questionnaire), health economic as well as safety and trial process data will be measured. The primary outcome is change in exercise capacity between visit 1 and visit 2. Two sample t-tests on an intention to treat basis will be used to estimate the difference in mean primary and secondary outcomes between patients randomised to PR-gym and PR-min.Ethics and disseminationLondon-Camden and Kings Cross Research Ethics Committee and Health Research Authority have approved the study (18/LO/0315). Results will be submitted for publication in peer-reviewed journals, presented at international conferences, disseminated through social media, patient and public routes and directly shared with stakeholders.Trial registration numberISRCTN16196765.

What Predicts Peak Exercise Capacity In Patients With Chronic Lung Disease?

2011 ◽  
Author(s):  
Fatma Gargoum ◽  
Bernie O'Connor ◽  
Robert O Farrell ◽  
Faheem Khan ◽  
Barry Kennedy ◽  
...  
Keyword(s):  
Lung Disease ◽  
Exercise Capacity ◽  
Chronic Lung Disease ◽  
Peak Exercise

High-Frequency Oscillation and Chronic Lung Disease in Very Low Birth Weight Infants

PEDIATRICS ◽  
2001 ◽  
Vol 108 (1) ◽  
pp. 212-214
Author(s):  
J. P. Shenai; ◽  
P. Rimensberger; ◽  
U. Thome ◽  
F. Pohlandt; ◽  
P. Rimensberger
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Lung Disease ◽  
Chronic Lung Disease ◽  
High Frequency ◽  
Very Low Birth Weight ◽  
High Frequency Oscillation ◽  
Frequency Oscillation ◽  
Low Birth Weight Infants
Sign in / Sign up

Export Citation Format

Share Document