scholarly journals The effects of high-sensitivity C-reactive protein on the clinical outcomes in obstructive sleep apnea patients undergoing off-pump coronary artery bypass grafting

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Mingxin Gao ◽  
Kangjun Fan ◽  
Wenyuan Yu ◽  
Hongli Liu ◽  
Yongxiang Wei ◽  
...  
Keyword(s):  
Artery Bypass ◽  
High Sensitivity ◽  
Bypass Grafting ◽  
C Reactive Protein ◽  
Off Pump ◽  
Reactive Protein ◽  
Obstructive Sleep ◽  
Duration Of Hospitalization ◽  
Hs Crp ◽  
The Relationship

Abstract Purpose To investigate the relationship between obstructive sleep apnea (OSA) severity and high-sensitivity C-reactive protein (Hs-CRP), and their respective impact on the clinical outcomes in patients undergoing off-pump cardiac artery bypass grafting (OPCABG). Methods We enrolled consecutive eligible patients listed for elective OPCABG who underwent cardiorespiratory polygraphy before surgery between January 2019 and December 2019 in this prospective observational single-center study. Baseline, intraoperative, and postoperative clinical data were compared between absent-mild and moderate-severe OSA groups. Regression analysis investigated the relationship between Hs-CRP level and severity of OSA, and further assessed the factors influencing postoperative atrial fibrillation, duration of hospitalization, and hospital cost. Results Patients with moderate-severe OSA accounted for 42.3% (52/123) of the cohort. Partial pressure of carbon dioxide (PCO2), Hs-CRP, apnea hypopnea index (AHI), mean apnea time, maximum apnea time, and oxygen desaturation index ODI ≥ 3% were significantly higher in the moderate-severe OSA group than in the absent-mild OSA group. Left ventricle ejection fraction (LVEF), lowest arterial oxygen saturation (SaO2), and mean SaO2 were significantly lower in the moderate-severe OSA group. Moderate-severe OSA was associated with elevated Hs-CRP level (OR = 2.356, 95% CI 1.101–5.041, P = 0.027). Hs-CRP was an independent risk factor for post-CABG atrial fibrillation (POAF) (OR = 1.212, P = 0.01). Hs-CRP level independently correlated with duration of hospitalization (B = 0.456, P = 0.001) and hospital cost (B = 1.111, P = 0.044). Conclusion Hs-CRP level was closely related to OSA severity and have potential utility in predicting POAF, duration of hospitalization, and hospital costs in patients undergoing OPCABG.

scholarly journals The effects of obstructive sleep apnea and high-sensitivity C-reactive protein on clinical outcome in off-pump coronary artery bypass grafting

2021 ◽  
Author(s):  
Mingxin Gao ◽  
Kangjun Fan ◽  
Wenyuan Yu ◽  
Hongli Liu ◽  
Yongxiang Wei ◽  
...  
Keyword(s):  
Artery Bypass ◽  
High Sensitivity ◽  
Bypass Grafting ◽  
C Reactive Protein ◽  
Off Pump ◽  
Reactive Protein ◽  
Obstructive Sleep ◽  
Duration Of Hospitalization ◽  
Hs Crp ◽  
The Relationship

Abstract Purpose This study aimed to investigate the relationship between obstructive sleep apnea (OSA) and high-sensitivity C-reactive protein (hs-CRP) to determine their effects on postoperative complications and clinical outcomes during hospitalization in patients undergoing off-pump cardiac artery bypass grafting (OPCABG). Methods This prospective, single-center study enrolled patients who underwent OPCABG. OSA was evaluated using a portable sleep monitor before OPCABG. Spearman correlation was performed to investigate the relationship between hs-CRP and polygraphy test indicators; regression analysis was performed to determine whether hs-CRP is an independent influencing factor for postoperative atrial fibrillation, duration of hospitalization, and hospital cost. Results Partial pressure of carbon dioxide (P = 0.033), high-sensitivity C-reactive protein (hs-CRP) (P = 0.001), apnea hypopnea index (AHI) (P = 0.000), mean apnea time (P = 0.000), maximum apnea time (P = 0.000), and ODI ≥ 3% (P = 0.000) were significantly higher in the moderate–severe OSA group than in the absent–mild OSA group. LVEF (P = 0.034), lowest arterial oxygen saturation (SaO2) (P = 0.000), and mean SaO2 (P = 0.000) were significantly lower in the moderate–severe OSA group. Hs-CRP levels correlated with AHI (rs = 0.235, P = 0.009), ODI ≥ 3% (rs = 0.228, P = 0.011), lowest SaO2 (rs = 0.186, P = 0.040), and mean SaO2 (rs = 0.331, P = 0.000). AHI independently correlated with hs-CRP levels (P = 0.01); hs-CRP was an independent risk factor for post-CABG atrial fibrillation (POAF) (OR = 1.17, P = 0.006); and hs-CRP level independently correlated with duration of hospitalization (P = 0.002) and hospital cost (P = 0.040). Conclusion Hs-CRP levels are closely related to the degree of OSA and have potential utility in predicting POAF, duration of hospitalization, and hospital costs in patients undergoing OPCABG.

scholarly journals A prospective follow-up study of the relationship between high-sensitivity C-reactive protein and primary liver cancer

BMC Cancer ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Sarah Tan Siyin ◽  
Tong Liu ◽  
Wenqiang Li ◽  
Nan Yao ◽  
Guoshuai Xu ◽  
...  
Keyword(s):  
Liver Cancer ◽  
Regression Models ◽  
Primary Liver Cancer ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
The Relationship ◽  
New Onset

Abstract Background Competing risk method has not been used in a large-scale prospective study to investigate whether increased levels of high-sensitivity C-reactive protein (hs-CRP) elevate the risk of primary liver cancer (PLC). Our study aims to prospectively investigate the relationship between hs-CRP and new-onset PLC. Methods and results Ninety-five thousand seven hundred fifty-nine participants without the diagnosis of PLC, and who had their demographic characteristics and biochemical parameters recorded, were analyzed from the Kailuan Cohort study. Cox proportional hazards regression models and competing risk regression models were used to evaluate the hazard ratios (HRs) and 95% confidence intervals (95% CIs) of PLC. During a median follow-up of 11.07 years, 357 incidental PLC cases were identified over a total of 1,035,039 person-years. The multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.07(0.82 ~ 1.38), 1.51(1.15 ~ 1.98) in a Cox proportional hazard regression analysis adjusted for other potential confounders. In the cause-specific hazard model, the multivariable HRs (95%CI) for the association of hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L with PLC were 1.06(0.81 ~ 1.40), 1.50(1.14 ~ 1.99). Similar results were also observed in the sub-distribution hazard function model with corresponding multivariate HRs (95%CI) of 1.05(0.80 ~ 1.40), 1.49(1.13 ~ 1.98) in hs-CRP of 1–3 mg/L group and hs-CRP>3 mg/L group, respectively. Conclusions This prospective study found a significant association of higher levels of hs-CRP with new-onset PLC. The main clinical implications would be an increased awareness of hs-CRP and its correlation to the risk of PLC. This study should be a steppingstone to further research on chronic inflammation and PLC. Trial registration Registration number:ChiCTR–TNRC–11001489.

Mediation effect of C-reactive protein in the relationship between abdominal obesity and intermediate hyperglycemia in Kuwaiti adolescents

2020 ◽  
Vol 14 (15) ◽  
pp. 1427-1437
Author(s):  
Hend Alqaderi ◽  
Ebaa Al-Ozairi ◽  
Saadoun Bin-Hasan ◽  
Mary Tavares ◽  
Jo M Goodson ◽  
...  
Keyword(s):  
Abdominal Obesity ◽  
Fasting Blood Glucose ◽  
High Sensitivity ◽  
Mediating Effect ◽  
Mediation Effect ◽  
Multilevel Regression ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
The Relationship

Aim: This study aimed to investigate the mediating effect of C-reactive protein (CRP) on obesity and hyperglycemia. Materials & methods: Fasting blood glucose, high-sensitivity CRP (hs-CRP) levels and waist circumference (WC) were measured on 353 participants. Multilevel regression modeling and mediation analyses were used to investigate the link between abdominal obesity, hs-CRP and hyperglycemia. Results: Elevation in hs-CRP was predictive of hyperglycemia in nonobese individuals (OR = 1.3, p = 0.03). With every 1-mg/l increase in hs-CRP, there was a 1-cm increase in WC (B = 0.87, p = 0.001). hs-CRP was a full mediator in the relationship between WC and hyperglycemia. Conclusion: hs-CRP predicts hyperglycemia development in nonobese individuals and the effect of increased WC on hyperglycemia was fully mediated by hs-CRP.

scholarly journals Association of Mitral Annulus Calcification with High-Sensitivity C-Reactive Protein, Which Is a Marker of Inflammation

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Ertuğrul Kurtoğlu ◽  
Hasan Korkmaz ◽  
Erdal Aktürk ◽  
Mücahid Yılmaz ◽  
Yakup Altaş ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Systemic Inflammation ◽  
High Sensitivity ◽  
Control Group ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Hs Crp ◽  
Artery Disease ◽  
The Relationship

Objectives. There are limited clinical data revealing the relationship between mitral annular calcification (MAC) and systemic inflammation. The goal of the present study was to compare high-sensitivity C-reactive protein (hs-CRP) levels in patients with and without MAC and investigate the relationship between MAC and hs-CRP.Methods. One hundred patients with MAC who underwent transthoracic echocardiography (TTE) and 100 age-matched controls without MAC who underwent TTE were included in our study. Hs-CRP levels were compared between groups.Results. Prevalence of female gender, hypertension, and coronary artery disease were significantly higher in the MAC group than in the control group (64% versus 45%,P=0.007, 42% versus 28%,P=0.03and 37% versus 18%,P=0.003, resp.). On multivariate analysis, age, gender, and coronary artery disease were the only independent predictors of MAC. The levels of hs-CRP were higher in the MAC group than in the control group (2.02±0.35versus1.43±0.47 mg/dl,P<0.001). This increase in hs-CRP levels in the MAC group persisted in patients without hypertension, coronary artery disease, and in male patients when compared to the control group.Conclusions. Our study demonstrated that hs-CRP, which is a sensitive marker of systemic inflammation, increased in patients with MAC.

scholarly journals Nocturnal Continuous Positive Airway Pressure (nCPAP) Decreases High-Sensitivity C-Reactive Protein (hs-CRP) in Obstructive Sleep Apnea-Hypopnea Syndrome

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Sameh Msaad ◽  
Akram Chaabouni ◽  
Rim Marrakchi ◽  
Mariem Boudaya ◽  
Amina Kotti ◽  
...  
Keyword(s):  
Obstructive Sleep Apnea ◽  
Airway Pressure ◽  
Positive Airway Pressure ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Obstructive Sleep ◽  
Median Plasma ◽  
Hs Crp ◽  
Hypopnea Syndrome

Background. Systemic and airway inflammation has recently been linked to obstructive sleep apnea-hypopnea syndrome (OSAHS) and is considered to be a probable risk factor for OSAHS-induced cardiovascular damage. High-sensitivity C-reactive protein (hs-CRP), as an inflammatory mediator, may be useful for the prediction of the risk of cardiovascular disease (CVD) and assessment of nocturnal continuous positive airway pressure (nCPAP) therapy effect in OSAHS patients. Methods. A prospective, controlled, cross-sectional study was conducted on 64 consecutive adult subjects with suspected sleep-disordered breathing (SDB). Results. OSAHS was confirmed in 43 patients (24 normotensive and 19 hypertensive patients) and ruled out in 21 normotensive subjects (controls). The median plasma level of hs-CRP did not differ significantly between OSAHS patients and controls. It showed an unmarked rise with the severity of OSAHS ( p = 0.20 ) and was not correlated with AHI ( p = 0.067 ; r = 0.28 ). After adjusting for cervical perimeter (CP), waist-to-hip ratio (WHR), and blood sugar level, hs-CRP level of 1 mg/dL or greater was significantly more often observed in OSAHS patients compared with controls ( p = 0.032 ; OR = 5.60 ) and was also significantly associated with AHI ( p = 0.021 ). A significant decrease in the median plasma hs-CRP level was observed in CPAP compliant patients ( p = 0.006 ). Of those, only normotensive patients showed a significant decrease in plasma hs-CRP level. In hypertensive ones, however, the hs-CRP level dropped but not significantly. Using a linear regression model, the change in hs-CRP level (Δhs-CRP) following a 6-month-nCPAP therapy was found to positively correlate with the baseline hs-CRP level for both hypertensive ( p = 0.02 ; r = 0.68 ), and even more normotensive OSAHS patients ( p < 0.0001 ; r = 0.89 ). Conclusion. nCPAP therapy may have a cardiovascular protective effect in OSAHS patients. hs-CRP level would be useful as a valuable predictor of success in OSAHS treatment monitoring.

The relationship between high-sensitivity C-reactive protein levels and the severity of obstructive sleep apnea

2011 ◽  
Vol 16 (1) ◽  
pp. 217-221 ◽  
Author(s):  
Selma Firat Guven ◽  
Mustafa Hamidullah Turkkani ◽  
Bulent Ciftci ◽  
Tansu Ulukavak Ciftci ◽  
Yurdanur Erdogan
Keyword(s):  
Obstructive Sleep Apnea ◽  
Sleep Apnea ◽  
High Sensitivity ◽  
C Reactive Protein ◽  
Protein Levels ◽  
Reactive Protein ◽  
Obstructive Sleep ◽  
The Relationship
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