scholarly journals Impaired kidney function is associated with lower cognitive function in the elder general population. Results from the Good Aging in Skåne (GÅS) cohort study

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Tomas Månsson ◽  
Marieclaire Overton ◽  
Mats Pihlsgård ◽  
Sölve Elmståhl
Keyword(s):  
Cohort Study ◽  
Executive Function ◽  
Cognitive Function ◽  
General Population ◽  
Learning And Memory ◽  
Kidney Function ◽  
Sex Education ◽  
Cognitive Domains ◽  
Global Cognitive Function ◽  
Complex Attention

Abstract Background A possible connection on vascular basis between impaired kidney function and cognitive dysfunction has been suggested in previous studies. Contradictory results regarding specific cognitive domains have been reported. The aim for this study was to investigate the association between kidney function and specific cognitive domains. Methods In this cross-sectional design, data from the general population based cohort study “Good aging in Skåne” (GÅS) was used. The sample included 2931 subjects ages 60 to 93 randomly selected from the southern part of Sweden. Estimated glomerular filtration rate (eGFR) for both creatinine and cystatine C was calculated using the chronic kidney disease epidemiology collaboration (CKD-EPI) equation. The subjects underwent a test battery of neuropsychological tests assessing global cognitive function, learning and memory, language, complex attention, executive function, perceptual motor and meta-memory. Adjustments were made for age, sex, education and country of origin. Results After adjustment for demographic variables, impaired kidney function was associated with 0.41 points worse result in MMSE, 0.56 points worse result in recognition, 0.66 points worse result in word fluency, 0.45 points worse result in digit cancellation, 0.99 points worse result in pattern comparison, and 3.71 s longer time to finish TMT B-A. Associations to cognitive function was also noted for mildly impaired kidney function defined as eGFR 45- < 60 ml/min/1,73m2. No association was found between kidney function and meta-memory. Conclusions Impaired kidney function as well as the severity of impaired kidney function is associated with impairment in learning and memory, language, complex attention, executive function and global cognitive function, but not meta-memory.

scholarly journals Effects of dance on cognitive function in older adults: a systematic review and meta-analysis

2020 ◽  
Author(s):  
Patricia Hewston ◽  
Courtney Clare Kennedy ◽  
Sayem Borhan ◽  
Dafna Merom ◽  
Pasqualina Santaguida ◽  
...  
Keyword(s):  
Older Adults ◽  
Executive Function ◽  
Cognitive Function ◽  
Learning And Memory ◽  
Optimal Dose ◽  
Future Research ◽  
Trail Making Test ◽  
Global Cognitive Function ◽  
Trail Making ◽  
Complex Attention

Abstract Background dance is a mind–body activity that stimulates neuroplasticity. We explored the effect of dance on cognitive function in older adults. Methods we searched MEDLINE, EMBASE, CENTRAL and PsycInfo databases from inception to August 2020 (PROSPERO:CRD42017057138). Inclusion criteria were (i) randomised controlled trials (ii) older adults (aged ≥ 55 years), (iii) intervention—dance and (iv) outcome—cognitive function. Cognitive domains were classified with the Diagnostic and Statistical Manual of Mental Disorders-5 Neurocognitive Framework. Meta-analyses were performed in RevMan5.3 and certainty of evidence with GradePro. Results we reviewed 3,997 records and included 11 studies (N = 1,412 participants). Seven studies included only healthy older adults and four included those with mild cognitive impairment (MCI). Dance interventions varied in frequency (1–3×/week), time (35–60 minutes), duration (3–12 months) and type. We found a mean difference (MD) = 1.58 (95% confidence interval [CI) = 0.21–2.95) on the Mini Mental State Examination for global cognitive function (moderate-certainty evidence), and the Wechsler Memory Test for learning and memory had an MD = 3.02 (95% CI = 1.38–4.65; low-certainty evidence). On the Trail Making Test-A for complex attention, MD = 3.07 (95% CI = −0.81 to 6.95; high-certainty evidence) and on the Trail Making Test-B for executive function, MD = −4.12 (95% CI = −21.28 to 13.03; moderate-certainty evidence). Subgroup analyses did not suggest consistently greater effects in older adults with MCI. Evidence is uncertain for language, and no studies evaluated social cognition or perceptual–motor function. Conclusions dance probably improves global cognitive function and executive function. However, there is little difference in complex attention, and evidence also suggests little effect on learning and memory. Future research is needed to determine the optimal dose and if dance results in greater cognitive benefits than other types of physical activity and exercise.

scholarly journals Association of gait with global cognitive function and cognitive domains detected by MoCA-J among community-dwelling older adults: a cross-sectional study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wen Hao ◽  
Wenjing Zhao ◽  
Takashi Kimura ◽  
Shigekazu Ukawa ◽  
Ken Kadoya ◽  
...  
Keyword(s):  
Executive Function ◽  
Cognitive Function ◽  
Cross Sectional Study ◽  
Community Dwelling ◽  
Initial Contact ◽  
Sectional Study ◽  
Cross Sectional ◽  
Cognitive Domains ◽  
Global Cognitive Function ◽  
Gait Parameters

Abstract Background Gait was proved to be strongly associated with global cognitive function and multiple cognitive domains; however, previous research usually concentrated on individual gait parameters. This study used wearable sensors to measure gait parameters in different aspects and comprehensively explored the association of gait with global cognitive function and cognitive domains. Methods The data of this cross-sectional study were obtained from 236 community-dwelling Japanese older adults (125 men and 111 women) aged 70–81 years. Gait was measured by asking participants to walk a 6-m course and back using the Physilog® sensors (GaiUp®, Switzerland). Global cognitive function and cognitive domains were evaluated by face-to-face interviews using the Japanese version of the Montreal Cognitive Assessment. Twenty gait parameters were summarized as independent gait factors using factor analysis. A generalized linear model and linear regression model were used to explore the relationship of gait with global cognitive function and cognitive domains adjusted for several confounding factors. Results Factor analysis yielded four gait factors: general cycle, initial contact, propulsion, and mid-swing. Among them, general cycle factor was significantly associated with global cognitive function (β = − 0.487, [− 0.890, − 0.085]) and executive function (P = 0.049); initial contact was associated with executive function (P = 0.017). Conclusion General cycle of gait might be the better marker of global cognitive function and gait is most strongly associated with executive function. The longitudinal relationships should be examined in future cohort studies.

Abstract P350: The Link Between Cognitive Function and Cause-specific Mortality in US Adults

Circulation ◽  
2020 ◽  
Vol 141 (Suppl_1) ◽  
Author(s):  
Sanaz Sedaghat ◽  
Behnam SABAYAN ◽  
Farzaneh A Sorond ◽  
Mercedes R Carnethon
Keyword(s):  
Cognitive Function ◽  
Sex Education ◽  
Cardiovascular Mortality ◽  
Smoking History ◽  
Inverse Association ◽  
Cognitive Domains ◽  
Health And Nutrition ◽  
History Of ◽  
Mortality Table

Introduction: Multiple studies demonstrated an independent and inverse association between cognitive function and mortality but little is known about the cause of death. Hypothesis: We hypothesized that lower cognitive function is related to higher mortality risk and this association is stronger for cardiovascular related deaths. Methods: We included 5569 persons (mean[SE] age 71[0.05], 52% women), from the Third National Health and Nutrition Examination Survey (NHANES III) with available cognitive function measurements and mortality follow-up. Cognitive domains include orientation, attention, immediate and delayed memory as well as global cognition. We used weighted Cox proportional regression models adjusted for age, sex, education, systolic and diastolic blood pressure, body mass index, smoking, history of diabetes and cardiovascular disorders. Results: During an average follow-up of 12 years, 1887 participants died from cardiovascular causes and 2675 died from non-cardiovascular causes. Each SD lower global cognitive performance (SD=6) was related to a 1.11 (95% CI: 1.05, 1.17) higher hazard of all-cause mortality. The associations were more prominent with cardiovascular mortality than with non- cardiovascular mortality (Table). Conclusion: Cognitive impairment in the absence of manifest dementia is an important independent predictor of mortality, in particular from cardiovascular causes.

scholarly journals Recurrent diabetic ketoacidosis and cognitive function among older adults with type 1 diabetes: findings from the Study of Longevity in Diabetes

2020 ◽  
Vol 8 (1) ◽  
pp. e001173 ◽  
Author(s):  
Mary E Lacy ◽  
Paola Gilsanz ◽  
Chloe W Eng ◽  
Michal S Beeri ◽  
Andrew J Karter ◽  
...  
Keyword(s):  
Older Adults ◽  
Type 1 Diabetes ◽  
Executive Function ◽  
Cognitive Function ◽  
Diabetic Ketoacidosis ◽  
Brain Health ◽  
Psychomotor Speed ◽  
Logistic Regression Models ◽  
Global Cognitive Function

IntroductionDiabetic ketoacidosis (DKA) is a serious complication of diabetes. DKA is associated with poorer cognition in children with type 1 diabetes (T1D), but whether this is the case in older adults with T1D is unknown. Given the increasing life expectancy in T1D, understanding the role of DKA on brain health in older adults is crucial.Research design and methodsWe examined the association of DKA with cognitive function in 714 older adults with T1D from the Study of Longevity in Diabetes. Participants self-reported lifetime exposure to DKA resulting in hospitalization; DKA was categorized into 0 hospitalization, 1 hospitalization or ≥2 hospitalizations (recurrent DKA). Global and domain-specific cognition (language, executive function/psychomotor speed, episodic memory and simple attention) were assessed. The association of DKA with cognitive function was evaluated via linear and logistic regression models.ResultsTwenty-eight percent of participants (mean age=67 years; mean age at diagnosis=28 years; average duration of diabetes=39 years) reported a lifetime history of DKA resulting in hospitalization (18.5% single DKA; 9.7% recurrent DKA). In fully adjusted models, those with recurrent DKA had lower global cognitive function (β=−0.13; 95% CI −0.22 to 0.02) and lower scores on the executive function/psychomotor speed domain (β=−0.34; 95% CI −0.51 to 0.17). Individuals with recurrent DKA were also more likely to have the lowest level of cognitive function on the executive function/psychomotor speed domain (defined as 1.5 SD below the population mean; OR=3.26, 95% CI 1.43 to 7.42).ConclusionsAmong 714 older adults with T1D, recurrent DKA was associated with lower global cognitive function, lower scores on the executive function/psychomotor speed domain and 3.3 times greater risk of having the lowest level of cognitive function in our sample on the executive function/psychomotor speed domain. These findings suggest that recurrent DKA may negatively impact the brain health of older patients with T1D and highlight the importance of DKA prevention.

scholarly journals Impact of Virtual Reality-Based Therapies on Cognition and Mental Health of Stroke Patients: Systematic Review and Meta-analysis

10.2196/31007 ◽  
2021 ◽  
Vol 23 (11) ◽  
pp. e31007
Author(s):  
Qi Zhang ◽  
Yu Fu ◽  
Yanhui Lu ◽  
Yating Zhang ◽  
Qifang Huang ◽  
...  
Keyword(s):  
Mental Health ◽  
Virtual Reality ◽  
Executive Function ◽  
Cognitive Function ◽  
Verbal Fluency ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Visuospatial Function ◽  
Global Cognitive Function

Background Stroke remains one of the major chronic illnesses worldwide that health care organizations will need to address for the next several decades. Individuals poststroke are subject to levels of cognitive impairment and mental health problems. Virtual reality (VR)-based therapies are new technologies used for cognitive rehabilitation and the management of psychological outcomes. Objective This study performed a meta-analysis to evaluate the effects of VR-based therapies on cognitive function and mental health in patients with stroke. Methods A comprehensive database search was performed using PubMed, MEDLINE (Ovid), Embase, Cochrane Library, and APA PsycINFO databases for randomized controlled trials (RCTs) that studied the effects of VR on patients with stroke. We included trials published up to April 15, 2021, that fulfilled our inclusion and exclusion criteria. The literature was screened, data were extracted, and the methodological quality of the included trials was assessed. Meta-analysis was performed using RevMan 5.3 software. Results A total of 894 patients from 23 RCTs were included in our meta-analysis. Compared to traditional rehabilitation therapies, the executive function (standard mean difference [SMD]=0.88, 95% confidence interval [CI]=0.06-1.70, P=.03), memory (SMD=1.44, 95% CI=0.21-2.68, P=.02), and visuospatial function (SMD=0.78, 95% CI=0.23-1.33, P=.006) significantly improved among patients after VR intervention. However, there were no significant differences observed in global cognitive function, attention, verbal fluency, depression, and the quality of life (QoL). Conclusions The findings of our meta-analysis showed that VR-based therapies are efficacious in improving executive function, memory, and visuospatial function in patients with stroke. For global cognitive function, attention, verbal fluency, depression, and the QoL, further research is required. Trial Registration PROSPERO International Prospective Register of Systematic Reviews CRD42021252788; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=252788

Cross-Lagged Modeling of Cognition and Social Network Size in the Sydney Memory and Ageing Study

2020 ◽  
Author(s):  
Anne-Nicole S Casey ◽  
Zhixin Liu ◽  
Nicole A Kochan ◽  
Perminder S Sachdev ◽  
Henry Brodaty
Keyword(s):  
Social Network ◽  
Cognitive Function ◽  
Social Relationships ◽  
Sex Education ◽  
Cognitive Abilities ◽  
Network Size ◽  
Older Age ◽  
Cognitive Domains ◽  
Social Network Size ◽  
Ageing Study

Abstract Objectives This study assessed whether reciprocal relationships exist between cognitive function and the social network size of older adults, controlling for age, sex, education, medical conditions, and depressive symptoms. Methods Data were collected at biennial follow-ups over 6 years in the Sydney Memory and Ageing Study, a longitudinal cohort study including 1,037 community-based Sydney residents aged 70–90 years without dementia at baseline. We used random intercept cross-lagged panel models to investigate reciprocal associations between social network size and scores in each of 7 cognitive domains including a global score. Results Standardized models indicated that within-person deviation in expected language score predicted deviation in expected network size. Within-person deviation in prior expected social network size predicted deviation in expected executive function at year 6. Cross-lagged effects in models of both global cognition and memory, respectively, could not be attributed solely to within-person change. Discussion Findings support a co-constitutive view of cognitive function and social relationships in older age. Although both cognition and network size declined over time, slower than expected decline in language ability predicted less than expected contraction in social networks. A similar influence of network size on executive functioning indicated that relationships with friends and family outside of the home contributed significantly to the maintenance of higher order cognitive abilities in older late life. Diverse patterns of influence between cognitive domains and social network size over 6 years underscore the importance of assessing the complex and nuanced interplay between brain health and social relationships in older age.

scholarly journals Tea consumption and measures of attention and psychomotor speed in the very old: the Newcastle 85+ longitudinal study

BMC Nutrition ◽  
2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Edward Jonathan Okello ◽  
Nuno Mendonça ◽  
Blossom Stephan ◽  
Graciela Muniz-Terrera ◽  
Keith Wesnes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cognitive Function ◽  
Sustained Attention ◽  
Community Dwelling ◽  
Tea Consumption ◽  
Psychomotor Speed ◽  
Very Old ◽  
Old Adults ◽  
Global Cognitive Function ◽  
Over Time

Abstract Background A number of studies have indicated a beneficial effect of tea consumption on the reduction of risk of cognitive impairment and dementia in older aged populations. However, there is a paucity of data on these associations in the very old, defined as individuals aged 85 years and over. We investigated the relationship between tea consumption in the very old and measures of global cognitive function, memory, attention and psychomotor speed. Method Longitudinal (5-years), population-based cohort study of individuals aged 85+ years in the North East of England, United Kingdom. Participants were community-dwelling and institutionalized men and women recruited through general medical practices (n = 676). Baseline tea consumption and longitudinal measures of global and domain specific (memory, speed and attention) cognitive function were assessed. Linear mixed models, controlling for demographic (e.g. age, sex and education) and health variables were used to determine whether tea consumption was protective against cognitive decline. Results Tea consumption was not associated with cognitive function at baseline on any measure (unadjusted and adjusted analyses). In the linear mixed effects models adjusted for age, sex, education and disease co-morbidity, higher tea consumption was associated with significantly better attention (focused and sustained attention), and psychomotor speed (complex tasks only) over five-years follow-up. However, there was no association between tea consumption and global cognitive function, memory or performance on simple speed tasks over time. Conclusions In this cohort study of non-demented very old adults we found that higher (vs. lower) tea consumption was associated with better performance over time on measures of focused and sustained attention and some psychomotor speed tasks. No associations with global cognition, memory or easy speed tasks (simple Reaction Time or Word Recognition) were detected. The results have implications for the development of possible diet-based interventions focused on improving cognitive function in the very old age group. These findings need to be confirmed in a sufficiently powered and well-designed RCT with non-demented very old adults.

scholarly journals Examination of attention, executive function, and memory as predictors of mortality risk in adults with systolic heart failure

2019 ◽  
Vol 18 (8) ◽  
pp. 729-735 ◽  
Author(s):  
Emily C Gathright ◽  
Mary A Dolansky ◽  
John Gunstad ◽  
Richard A Josephson ◽  
Shirley M Moore ◽  
...  
Keyword(s):  
Heart Failure ◽  
Cognitive Impairment ◽  
Executive Function ◽  
Cognitive Function ◽  
Mortality Risk ◽  
Systolic Heart Failure ◽  
Screening Tools ◽  
Cognitive Domain ◽  
Mortality Data ◽  
Global Cognitive Function

Background: The prevalence and impact of cognitive impairment in heart failure is increasingly recognized. Converging evidence points to global cognitive function as predictive of prognosis in adults with heart failure when assessed with screening tools. Additional work is needed to understand which domains of cognitive function are most relevant for prognosis. Aims: The present study sought to examine associations between domains of cognitive function and mortality risk in adults with heart failure. Methods: In the present prospective, observational cohort study, global cognitive function, attention, executive function, and memory were assessed by means of a comprehensive neuropsychogical battery in adults with systolic heart failure. Mortality data were obtained from the National Death Index (median follow-up 2.95 years). Relationships among each cognitive domain and mortality were assessed with Cox regression. Covariates included age, sex, heart failure severity, comorbidity and depressive symptoms. Results: Participants were 325 patients with systolic heart failure with a mean age of 68.6 years (59% men, 73% Caucasian). Following covariate adjustment, better global cognitive function, attention, and executive function were related to decreased mortality risk. Conclusions: Future research is needed to clarify the underlying mechanisms of the association between cognitive impairment and mortality.

Association of Impaired Kidney Function With Mortality in Rural Uganda: Results of a General Population Cohort Study

2020 ◽  
Author(s):  
Robert Kalyesubula ◽  
Isaac Sekitoleko ◽  
Keith Tomlin ◽  
Christian Holm Hansen ◽  
Billy Ssebunya ◽  
...  
Keyword(s):  
Cohort Study ◽  
General Population ◽  
Kidney Function ◽  
Population Cohort ◽  
General Population Cohort ◽  
Population Cohort Study
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