scholarly journals Culture positivity may correlate with long-term mortality in critically ill patients

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Wei-Fan Ou ◽  
Li-Ting Wong ◽  
Chieh-Liang Wu ◽  
Wen-Cheng Chao
Keyword(s):  
Critical Care ◽  
Urinary Tract ◽  
Respiratory Tract ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Positive Culture ◽  
Culture Positivity ◽  
Long Term Mortality ◽  
Overall Mortality

Abstract Background The long-term outcome is currently a crucial issue in critical care, and we aim to address the association between culture positivity and long-term mortality in critically ill patients. Methods We used the 2015–2019 critical care database at Taichung Veterans General Hospital and Taiwanese nationwide death registration files. Multivariable Cox proportional hazards regression model was conducted to determine hazard ratio (HR) and 95% confidence interval (CI). Results We enrolled 4488 critically ill patients, and the overall mortality was 55.2%. The follow-up duration among survivors was 2.2 ± 1.3 years. We found that 52.6% (2362/4488) of critically ill patients had at least one positive culture during the admission, and the number of patients with positive culture in the blood, respiratory tract and urinary tract were 593, 1831 and 831, respectively. We identified that a positive culture from blood (aHR 1.233; 95% CI 1.104–1.378), respiratory tract (aHR 1.217; 95% CI 1.109–1.364) and urinary tract (aHR 1.230; 95% CI 1.109–1.364) correlated with an increased risk of long-term mortality after adjusting relevant covariates. Conclusions Through linking two databases, we found that positive culture in the blood, respiratory tract and urinary tract during admission correlated with increased long-term overall mortality in critically ill patients.

scholarly journals The association between culture positivity and long-term mortality in critically ill surgical patients

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yu-Cheng Wu ◽  
Li-Ting Wong ◽  
Chieh-Liang Wu ◽  
Wen-Cheng Chao
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Positive Culture ◽  
Surgical Patients ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Culture Positivity ◽  
Critically Ill Surgical Patients ◽  
Long Term Mortality

Abstract Background The long-term outcome is an essential issue in critically ill patients, and the identification of early determinant is needed for risk stratification of the long-term outcome. In the present study, we investigate the association between culture positivity during admission and long-term outcome in critically ill surgical patients. Methods We linked the 2015–2019 critical care database at Taichung Veterans General Hospital with the nationwide death registration files in Taiwan. We described the long-term mortality and proportion of culture positivity among enrolled subjects. We used a log-rank test to estimate survival curves between patients with and without positive cultures and a multivariable Cox proportional hazards regression model to determine hazard ratio (HR) and 95% confidence interval (CI). Results A total of 6748 critically ill patients were enrolled, and 32.5% (2196/6749) of them died during the follow-up period, with the overall follow-up duration was 1.8 ± 1.4 years. We found that 31.4% (2122/6748) of critically ill patients had at least one positive culture during the index admission, and the number of patients with positive culture in the blood, respiratory tract, urinary tract, skin and soft tissue and abdomen were 417, 1702, 554, 194 and 139, respectively. We found that a positive culture from any sites was independently associated with high long-term mortality (aHR 1.579, 95% CI 1.422–1.754) after adjusting relevant covariates, including age, sex, body-mass index, comorbidities, severity score, shock, early fluid overload, receiving mechanical ventilation and the need of renal replacement therapy for critical illness. Conclusions We linked two databases to identify that a positive culture during admission was independently correlated with increased long-term mortality in critically ill surgical patients. Our findings highlight the need for vigilance among patients with a positive culture during admission, and more studies are warranted to validate our findings and to clarify underlying mechanisms.

scholarly journals Cystatin C predicts long term mortality better than creatinine in a nationwide study of intensive care patients

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Johanna Helmersson-Karlqvist ◽  
Miklos Lipcsey ◽  
Johan Ärnlöv ◽  
Max Bell ◽  
Bo Ravn ◽  
...  
Keyword(s):  
Intensive Care ◽  
Critically Ill ◽  
Risk Prediction ◽  
Cystatin C ◽  
Mortality Risk ◽  
Critically Ill Patients ◽  
Cox Regression ◽  
Sample Tube ◽  
Long Term Mortality

AbstractDecreased glomerular filtration rate (GFR) is linked to poor survival. The predictive value of creatinine estimated GFR (eGFR) and cystatin C eGFR in critically ill patients may differ substantially, but has been less studied. This study compares long-term mortality risk prediction by eGFR using a creatinine equation (CKD-EPI), a cystatin C equation (CAPA) and a combined creatinine/cystatin C equation (CKD-EPI), in 22,488 patients treated in intensive care at three University Hospitals in Sweden, between 2004 and 2015. Patients were analysed for both creatinine and cystatin C on the same blood sample tube at admission, using accredited laboratory methods. During follow-up (median 5.1 years) 8401 (37%) patients died. Reduced eGFR was significantly associated with death by all eGFR-equations in Cox regression models. However, patients reclassified to a lower GFR-category by using the cystatin C-based equation, as compared to the creatinine-based equation, had significantly higher mortality risk compared to the referent patients not reclassified. The cystatin C equation increased C-statistics for death prediction (p < 0.001 vs. creatinine, p = 0.013 vs. combined equation). In conclusion, this data favours the sole cystatin C equation rather than the creatinine or combined equations when estimating GFR for risk prediction purposes in critically ill patients.

scholarly journals Anemia Is a Risk Factor for Acute Kidney Injury and Long-Term Mortality in Critically Ill Patients

2015 ◽  
Vol 237 (4) ◽  
pp. 287-295 ◽  
Author(s):  
Seung Seok Han ◽  
Seon Ha Baek ◽  
Shin Young Ahn ◽  
Ho Jun Chin ◽  
Ki Young Na ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Risk Factor ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Kidney Injury ◽  
Long Term Mortality

Age still matters: Prognosticating short- and long-term mortality for critically ill patients with pneumonia

2010 ◽  
Vol 38 (11) ◽  
pp. 2126-2132 ◽  
Author(s):  
Wendy I. Sligl ◽  
Dean T. Eurich ◽  
Thomas J. Marrie ◽  
Sumit R. Majumdar
Keyword(s):  
Critically Ill ◽  
Critically Ill Patients ◽  
Short And Long Term ◽  
Long Term Mortality

Early Intensive Care Sedation Predicts Long-Term Mortality in Ventilated Critically Ill Patients

2012 ◽  
Vol 186 (8) ◽  
pp. 724-731 ◽  
Author(s):  
Yahya Shehabi ◽  
Rinaldo Bellomo ◽  
Michael C. Reade ◽  
Michael Bailey ◽  
Frances Bass ◽  
...  
Keyword(s):  
Intensive Care ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Intensive Care Sedation ◽  
Long Term Mortality

Elevated asymmetric dimethylarginine levels predict short- and long-term mortality risk in critically ill patients

2013 ◽  
Vol 28 (6) ◽  
pp. 947-953 ◽  
Author(s):  
Alexander Koch ◽  
Ralf Weiskirchen ◽  
Julian Kunze ◽  
Hanna Dückers ◽  
Jan Bruensing ◽  
...  
Keyword(s):  
Critically Ill ◽  
Mortality Risk ◽  
Critically Ill Patients ◽  
Asymmetric Dimethylarginine ◽  
Short And Long Term ◽  
Long Term Mortality

scholarly journals Elevation of blood urea nitrogen is predictive of long-term mortality in critically ill patients independent of “normal” creatinine*

2011 ◽  
Vol 39 (2) ◽  
pp. 305-313 ◽  
Author(s):  
Kevin Beier ◽  
Sabitha Eppanapally ◽  
Heidi S. Bazick ◽  
Domingo Chang ◽  
Karthik Mahadevappa ◽  
...  
Keyword(s):  
Critically Ill ◽  
Blood Urea Nitrogen ◽  
Critically Ill Patients ◽  
Urea Nitrogen ◽  
Long Term Mortality

scholarly journals The Impact of New-onset Atrial Fibrillation on Short-term and Long-term Mortality of Critically ill Patients with Candidemia

2021 ◽  
Author(s):  
zengli xiao ◽  
Qi Wang ◽  
Xuebin Li ◽  
Youzhong An
Keyword(s):  
Risk Factors ◽  
Atrial Fibrillation ◽  
Critically Ill ◽  
Critically Ill Patients ◽  
Short Term ◽  
The Impact ◽  
Onset Atrial Fibrillation ◽  
Long Term Mortality ◽  
New Onset

Abstract Background Both new-onset atrial fibrillation (NOAF) and candidemia occurred frequently in critically ill patients, which are associated with poor outcomes. But, the association between NOAF and critically ill patients with candidemia is still uncertain. This study is try to identify the impact of NOAF on short-term and long-term mortality of critically ill patients with candidemia. Methods We retrospectively identified NOAF in all patients with candidemia admitted to a non-cardiac intensive care unit (ICU) from January 2011 to March 2018 in a teaching hospital. We categorized these patients into 3 groups (NOAF, Prior AF, No AF) and compared clinical information between groups. Risk factors for these patients’ short-term and long-term mortality were also analyzed. Results Ninety-two patients with candidemia were identified from 2011 to 2018. Among these patients, 26 (28.3%) developed NOAF during their hospital stay. The multivariable logistic regression analysis indicated that stroke, anemia, Sequential Organ Failure Assessment (SOFA) score and NOAF were independent risk factors for in-hospital mortality and NOAF was also the independent risk factor for 1 year mortality. Conclusions There was a high incidence of NOAF in critically ill patients with candidemia, which was associated with in-hospital mortality and 1 year mortality after hospital discharge. Further multicenter studies should be conducted to help confirm this relationship and to find effective interventions that reduce short-term and long-term mortality.

Sign in / Sign up

Export Citation Format

Share Document