scholarly journals Evaluation of computed tomography settings in the context of visualization and discrimination of low dose injections of a novel liquid soft tissue fiducial marker in head and neck imaging

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
David Steybe ◽  
Philipp Poxleitner ◽  
Pit Jacob Voss ◽  
Marc Christian Metzger ◽  
Rainer Schmelzeisen ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Low Dose ◽  
Tumor Resection ◽  
Fiducial Marker ◽  
Fiducial Markers ◽  
Clinical Routine ◽  
Injection Volume ◽  
Tumor Bed ◽  
Oral Soft Tissue

Abstract Background Intraoperative incorporation of radiopaque fiducial markers at the tumor resection surface can provide useful assistance in identifying the tumor bed in postoperative imaging for RT planning and radiological follow-up. Besides titanium clips, iodine containing injectable liquid fiducial markers represent an option that has emerged more recently for this purpose. In this study, marking oral soft tissue resection surfaces, applying low dose injections of a novel Conformité Européenne (CE)-marked liquid fiducial marker based on sucrose acetoisobutyrate (SAIB) and iodinated SAIB (x-SAIB) was investigated. Methods Visibility and discriminability of low dose injections of SAIB/x-SAIB (10 µl, 20 µl, 30 µl) were systematically studied at different kV settings used in clinical routine in an ex-vivo porcine mandible model. Transferability of the preclinical results into the clinical setting and applicability of DE-CT were investigated in initial patients. Results Markers created by injection volumes as low as 10 µl were visible in CT imaging at all kV settings applied in clinical routine (70–120 kV). An injection volume of 30 µl allowed differentiation from an injection volume of 10 µl. In a total of 118 injections performed in two head and neck cancer patients, markers were clearly visible in 83% and 86% of injections. DE-CT allowed for differentiation between SAIB/x-SAIB markers and other hyperdense structures. Conclusions Injection of low doses of SAIB/x-SAIB was found to be a feasible approach to mark oral soft tissue resection surfaces, with injection volumes as low as 10 µl found to be visible at all kV settings applied in clinical routine. With the application of SAIB/x-SAIB reported for tumors of different organs already, mostly applying relatively large volumes for IGRT, this study adds information on the applicability of low dose injections to facilitate identification of the tumor bed in postoperative CT and on performance of the marker at different kV settings used in clinical routine.

High-dose and low-dose brachytherapy may be performed safely with soft tissue coverage in salvage treatment of recurrent head and neck cancer

2015 ◽  
Vol 221 (4) ◽  
pp. e118
Author(s):  
Peter W. Henderson ◽  
Bhupesh W. Parasahar ◽  
David M. Otterburn ◽  
David I. Kutler ◽  
Marc A. Cohen ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Soft Tissue ◽  
Head And Neck ◽  
Neck Cancer ◽  
Low Dose ◽  
Salvage Treatment ◽  
High Dose ◽  
Soft Tissue Coverage ◽  
Recurrent Head

Head and neck radiotherapy leading to extensive late oral soft-tissue necrosis

Oral Oncology ◽  
2022 ◽  
Vol 125 ◽  
pp. 105710
Author(s):  
Isabel Schausltz Pereira Faustino ◽  
Maria Georgaki ◽  
Alan Roger Santos-Silva ◽  
Pablo Agustin Vargas ◽  
Marcio Ajudarte Lopes
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Tissue Necrosis ◽  
Soft Tissue Necrosis ◽  
Head And Neck Radiotherapy ◽  
Oral Soft Tissue

Head and neck and intra-oral soft tissue sarcomas

Oral Oncology ◽  
1998 ◽  
Vol 34 (4) ◽  
pp. 292-296 ◽  
Author(s):  
M. Gorsky ◽  
J.B. Epstein
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Sarcomas ◽  
Oral Soft Tissue

scholarly journals Head and neck osteosarcoma: CT and MR imaging features

2020 ◽  
Vol 49 (2) ◽  
pp. 20190202
Author(s):  
Zhendong Luo ◽  
Weiguo Chen ◽  
Xinping Shen ◽  
Genggeng Qin ◽  
Jianxiang Yuan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Giant Cell ◽  
High Signal ◽  
Imaging Features ◽  
Matrix Mineralization ◽  
Imaging Characteristics ◽  
Mri Features ◽  
Signal Intensities ◽  
Ct And Mri

Objective: This study aims to assess the CT and MRI features of head and neck osteosarcoma (HNO). Methods: 37 HNOs were identified, and the following imaging characteristics were reviewed on CT and MRI. Results: A total of 37 patients(age 41.5 ± 15.0 years old; 16 males, 21 females) were included in the study. Tumours occurred in the maxilla (16, 43.2%), mandible (8, 21.6%), skull base (6, 16.2%), calvarium (5, 13.5%), paranasal sinuses (1, 2.7%) and cervical soft tissue (1, 2.7%). 16 patients received radiotherapy for nasopharyngeal carcinoma. Three patients (8.1%) developed osteosarcomas related to a primary bone disease. 16 of the (43.2%) tumours demonstrated lytic density on CT scans, followed by 13 (35.1%) showing mixed density and 7 (18.9%) with sclerotic density. Matrix mineralization was present in 32 (86.5%). 3 out of 24 (12.5%) tumours showed lamellar periosteal reactions, 21 out of 24 (87.5%) showed spiculated periosteal reactions. 12 tumours showed low signal intensities on T1WI, with 16 having heterogeneous signal intensities. 10 tumours showed high signal intensities on T2WI, and 18 showed heterogeneous signal intensities. With contrast-enhanced images, 3 tumours showed homogeneous enhancement (2 osteoblastic and 1 giant cell-rich), 18 tumours showed heterogeneous enhancement (13 osteoblastic, 4 fibroblastic and 1 giant cell-rich), and 7 tumours showed peripheral enhancement (6 chondroblastic and 1 osteoblastic). These tumours were characterized by soft tissue masses with a diameter of 5.6 ± 1.8 cm. Conclusions: HNO is a rare condition and is commonly associated with previous radiation exposure. This study provides age, sex distribution, location, CT and MRI features of HNO.

Hyperfractionated Radiation Therapy With or Without Concurrent Low-Dose Daily Cisplatin in Locally Advanced Squamous Cell Carcinoma of the Head and Neck: A Prospective Randomized Trial

2000 ◽  
Vol 18 (7) ◽  
pp. 1458-1464 ◽  
Author(s):  
Branislav Jeremic ◽  
Yuta Shibamoto ◽  
Biljana Milicic ◽  
Nebojsa Nikolic ◽  
Aleksandar Dagovic ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Low Dose ◽  
Locally Advanced ◽  
Progression Free Survival ◽  
High Grade ◽  
Free Survival

PURPOSE: To investigate whether the addition of cisplatin (CDDP) to hyperfractionation (Hfx) radiation therapy (RT) offers an advantage over the same Hfx RT given alone in locally advanced (stages III and IV) squamous cell carcinoma of the head and neck. PATIENTS AND METHODS: One hundred thirty patients were randomized to receive either Hfx RT alone to a tumor dose of 77 Gy in 70 fractions in 35 treatment days over 7 weeks (group I, n = 65) or the same Hfx RT and concurrent low-dose (6 mg/m2) daily CDDP (group II, n = 65). RESULTS: Hfx RT/chemotherapy offered significantly higher survival rates than Hfx RT alone (68% v 49% at 2 years and 46% v 25% at 5 years; P = .0075). It also offered higher progression-free survival (46% v 25% at 5 years; P = .0068), higher locoregional progression-free survival (LRPFS) (50% v 36% at 5 years; P = .041), and higher distant metastasis-free survival (DMFS) (86% v 57% at 5 years; P = .0013). However, there was no difference between the two treatment groups in the incidence of either acute or late high-grade RT-induced toxicity. Hematologic high-grade toxicity was more frequent in group II patients. CONCLUSION: As compared with Hfx RT alone, Hfx RT and concurrent low-dose daily CDDP offered a survival advantage, as well as improved LRPFS and DMFS.

Efficacy and tolerability of weekly low-dose cisplatin concurrent with radiotherapy in head and neck cancer patients

2011 ◽  
Vol 7 (3) ◽  
pp. 287-292 ◽  
Author(s):  
Zulfiquer OTTY ◽  
Monika Buhrer SKINNER ◽  
Joshua DASS ◽  
Michael COLLINS ◽  
Jennifer MOOI ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Cancer Patients ◽  
Neck Cancer ◽  
Low Dose

scholarly journals Distinctive Soft Tissue Tumors of the Head and Neck

2002 ◽  
Vol 15 (3) ◽  
pp. 324-330 ◽  
Author(s):  
Christopher D.M Fletcher
Keyword(s):  
Soft Tissue ◽  
Head And Neck ◽  
Soft Tissue Tumors
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