scholarly journals Resection of extrahepatic bile ducts with partial hepatectomy for treating intra- and extrahepatic hepatolithiasis

BMC Surgery ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
HongTian Xia ◽  
XiangFei Meng ◽  
XianLei Xin ◽  
Tao Yang ◽  
Yang Liu ◽  
...  
Keyword(s):  
Bile Duct ◽  
Surgical Procedures ◽  
Bile Ducts ◽  
Control Group ◽  
Efficacy Rate ◽  
Observation Group ◽  
Surgical Methods ◽  
Cox Analysis ◽  
Fair Poor

Abstract Background To evaluate the efficacy and safety of our new surgical procedures for primary intra- and extrahepatic hepatolithiasis. Hepatolithiasis is an intractable disease with frequent recurrences. Methods From 1996 to 2005, 142 patients with intrahepatic and/or extrahepatic hepatolithiasis treated with the conventional surgical methods were included as the control group, while 128 consecutive patients treated with new surgical methods from 2006 to 2015 were included as the observation group. The new surgical procedures included a comprehensive intraoperative exploration of the bile ducts, focusing on the structure and function of the hilar bile duct and duodenal papilla, exploration of the affected liver, and bile culture. Results The observation group had a significantly higher complete stone clearance rate than the control group (100% vs. 65.96%). The observation group had significantly lower incidences of cholangitis and bile duct stones, as well as a higher excellent and good long-term surgical efficacy rate (86.24% vs. 52.73%). Multivariate Cox analysis showed that the control group had a higher risk for fair + poor efficacy than the observation group (HR: 8.47). Conclusions Our new surgical procedures are safe and can provide a good long-term efficacy for treating primary hepatolithiasis intra- and extrahepatic hepatolithiasis.

scholarly journals FIBROCHOLODOSCOPY IN DIAGNOSTICS AND TREATMENT OF COMPLEX FORMS OF CHOLEDOCHOLITHIASIS

2019 ◽  
Vol 21 (1) ◽  
pp. 43-46
Author(s):  
K V Pavelets ◽  
A K Ushkats ◽  
D V Gacko
Keyword(s):  
Bile Duct ◽  
Common Bile Duct ◽  
Biliary Tract ◽  
Surgical Procedures ◽  
Bile Ducts ◽  
Diagnosis And Treatment ◽  
The Common ◽  
Complex Forms

Relevance of the topic: endoscopic intraoperative choledochoscopy with traditional surgical procedures is a highly informative research in the diagnosis and treatment of choledocholithiasis. Objective: to evaluate the effectiveness of intraoperative use of fibrocholedochoscopy in the diagnosis and treatment of "complex" forms of choledocholithiasis. Materials and methods: Between 2011 and 2017, 88 patients underwent treatment for "complicated" forms of choledocholithiasis using intraoperative fibrocholedochoscopy. Results: after dissection of the choledochal wall and extraction of large concrements from the lumen, a fibrocholedochoscopy was performed. The fibrocholedochoscope was inserted into the lumen of the common bile duct through a formed opening with examination of the biliary tract. An obligatory condition for assessing the permeability of the distal sections of the bile ducts was the carrying out of an endoscope through the OBD zone. The remaining remaining calculi were recovered with the help of Dormia baskets (15 (17%) cases). In 86 (97.7%) patients, the operation is completed by the imposition of a hollow stitch of choledoch (priority reference No. 2018122530, 2018). Conclusion: fibrocholedochoscopy in the treatment of complex forms of choledocholithiasis allows to methodically evaluate the biliary tract, perform lithoextraction from the proximal and distal sections.

scholarly journals Neoadjuvant Chemotherapy plus Bevacizumab Combined with Total Mesorectal Excision in Treating Locally Advanced Rectal Cancer Patients with BRAF Mutation: Clinical Benefit and Safety

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Jintian Song ◽  
Yi Wang ◽  
Hui Yu ◽  
Liang Zheng ◽  
Xiongchao Cai ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Clinical Benefit ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Control Group ◽  
Observation Group ◽  
Mesorectal Excision ◽  
Short Term

Objective. To investigate clinical benefit and safety of neoadjuvant chemotherapy (NAC) plus bevacizumab combined with total mesorectal excision (TME) in treating patients with BRAF-mutated locally advanced rectal cancer (LARC). Methods. This study included LARC patients with BRAF mutation admitted to the Oncology Department of Fujian Medical University Cancer Hospital, Fujian Cancer Hospital, between June 2013 and December 2018. Patients in the control group received a standard treatment regimen of TME combined with NAC ( n = 45 ), and patients in the observation group received NAC plus bevacizumab combined with TME ( n = 55 ). The short-term clinical efficacy of the two groups after NAC treatment was observed and compared, including differences in the pathological downstaging rate. The incidence of perioperative complications and adverse reactions during neoadjuvant therapy was compared to evaluate the safety of the treatment. Besides, the relapse-free survival (RFS) and overall survival (OS) of patients were analyzed to evaluate the long-term clinical benefit of the treatment. Results. Compared with the control group, the ypT staging rate ( p = 0.014 ) in the observation group was markedly lower. In addition, patients in the observation group had a prominently lower overall incidence of complications ( p < 0.001 ) during the perioperative period and a remarkably lower incidence of leukopenia ( p = 0.037 ) during neoadjuvant therapy. In terms of long-term clinical benefit, the RFS of patients in the observation group was evidently longer ( p = 0.037 ) than that in the control group. Conclusion. Compared with TME plus NAC treatment, the short-term and long-term clinical benefits are higher and safety is more favorable of NAC plus bevacizumab combined with TME in treating LARC patients.

scholarly journals Results of surgical treatment of extrahepatic bile duct injuries

2020 ◽  
Vol 37 (1) ◽  
pp. 63-72
Author(s):  
L. P. Kotelnikova ◽  
I. G. Burnyshev ◽  
O. V. Bazhenova ◽  
D. V. Trushnikov
Keyword(s):  
Laparoscopic Cholecystectomy ◽  
Surgical Treatment ◽  
Bile Duct ◽  
Bile Ducts ◽  
Bile Leakage ◽  
Biliary Reconstruction ◽  
Long Term Outcomes ◽  
Endoscopic Retrograde ◽  
Extrahepatic Bile Ducts

Aim. To evaluate the short-and long-term outcomes after surgical repair of iatrogenic lesions of extrahepatic bile ducts depending on the timing of diagnosis in conditions of specialized clinic. Materials and methods. Our study involved a retrospective analysis of 159 patients who were treated for iatrogenic lesions of extrahepatic bile ducts during 1987-2017. These patients were divided into two groups depending on the timing of surgical treatments: early biliary reconstruction ( 5 days after bile duct transection) and late biliary reconstruction ( 5 days post-transection). These groups were compared on the basis of postoperative morbidity and long-term outcomes. Results. Following laparoscopic cholecystectomy, 2 patients received endoscopic retrograde stents due to bile leakage from the cystic ducts, and 14 patients underwent hepaticocholedochostomy using Ker drainage. The incidence of bile leakage was observed in 14. 3 % of cases during the early post-operative period, strictures appeared in 28.6 % of cases. Hepaticojejunostomy was performed in 91 cases: in 62 with stents and in 29 without stents. Bile leakage was observed in 17.6 % of cases, and strictures in 19.8 % of cases. Our statistical analyses revealed no significant differences between the two groups (i.e., early and late timing of surgical treatment) in the rates of bile leakage and strictures. The extent of surgeons experience in bile surgery significantly correlated with positive outcomes. Conclusions. Endoscopic retrograde stent proved to be an effective and fast solution in cases of bile leakage from cystic ducts following laparoscopic cholecystectomy. Although it is preferable to perform reconstructive surgeries within the first five days after bile duct injury, our results indicated that in the presence of external bile fistula without peritonitis and severe cholangitis, reconstructive surgery can be performed in specialized surgical departments later than 5 days with satisfactory results.

Application of Standardized Nursing Procedures Combined with Specialized Management Education in Extracorporeal Membrane Oxygenation in ICU

2021 ◽  
Vol 7 (4) ◽  
pp. 647-654
Author(s):  
Min Zhang ◽  
Lingling Wu ◽  
Weihong Shen ◽  
Ying Shen
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
Completion Time ◽  
Management Education ◽  
Control Group ◽  
Average Weight ◽  
Efficacy Rate ◽  
Observation Group ◽  
Nursing Management ◽  
Preparation Time ◽  
Membrane Oxygenation

To analyze the application effect of standardized nursing procedures combined with specialized management education in extracorporeal membrane oxygenation (ECMO) in ICU. 18 patients treated with ECMO in our department from July 1, 2020 to December 30, 2020 were chosen as observation group, and 18 patients receiving ECMO in our department (January 2017-June 2018) were selected as control group. The control group received routine procedures in the implementation of ECMO nursing while the observation group received standardized ECMO nursing procedures combined with specialized management education to analyze the effect of different nursing management methods on ECMO patients by comparing the indexes before and after nursing management. There were no obvious differences in gender ratio, average age, average weight, average BMI, marital status, education and residence between the two groups (P > 0.05). Personnel arrival time, start time of rescue, preparation time of items, pipeline prefilling time and catheter completion time in observation group were obviously better compared with control group (P < 0.001). The total clinical efficacy rate in observation group was obviously higher compared with control group (P < 0.05). There were no significant differences in the Pa02, SP02 and PaC02 levels between the two groups before nursing management (P > 0.05), and the levels in observation group were obviously higher compared with control group after nursing management (P < 0.001). The clinical nursing satisfaction in observation group was obviously higher compared with control group (P < 0.05). The sequential organ failure assessment (SOFA) score in observation group after nursing management was obviously lower compared with control group (P < 0.001). The incidence of complications in observation group was obviously lower compared with control group (P < 0.05). The implementation of standardized nursing procedures combined with specialized management education for ECMO patients can effectively shorten rescue time, the preparation time before catheterization and catheter completion time, improve the therapeutic effect, and improve blood gas indicators, safe and effective. At the same time, it can facilitate the doctor-nurse cooperation, worthy of promotion and application.

scholarly journals Effect of Psychological Intervention Combined with Dietary Guidance on Quality of Life and Long-Term Efficacy of Bushen Quyu Decoction in Treatment of Patients with Advanced Ovarian Cancer

2021 ◽  
Vol 2021 ◽  
pp. 1-8
Author(s):  
Dan Liu ◽  
Guangwen Shi ◽  
Chao Yin ◽  
Zhendong Liu ◽  
Aixia Yang
Keyword(s):  
Quality Of Life ◽  
Ovarian Cancer ◽  
Psychological Intervention ◽  
Advanced Ovarian Cancer ◽  
Treatment Compliance ◽  
Control Group ◽  
Observation Group ◽  
Nursing Satisfaction

Objective. To study the effects of psychological intervention combined with dietary guidance on the quality of life and long-term efficacy of Bushen Quyu Decoction in the treatment of patients with advanced ovarian cancer. Methods. 220 patients with advanced (stages III to IV) ovarian cancer in our hospital from May 2015 to October 2018 were selected and randomly divided into a control group and an observation group, with 110 cases in each group. The patients in the control group received basic nursing care and treatment with Bushen Quyu Decoction, and the patients in the observation group were combined with psychological intervention and dietary guidance on the basis of the treatment of the patients in the control group. The clinical efficacy, nursing satisfaction, treatment compliance, quality of life, negative emotion comparison, and long-term efficacy of the two groups were compared. Moreover, the changes of immune function indexes and the content of tumor markers were compared between the two groups. Results. The total effective rate of treatment in the observation group (64.55%) was higher than that in the control group (31.82%). The nursing satisfaction of the observation group was 94.55%, the nursing satisfaction of the control group was 84.55%, and the difference was statistically significant p < 0.01 . The treatment compliance of the observation group was 98.18%, the treatment compliance of the control group was 82.73%, and the difference was statistically significant p < 0.0001 . After nursing, the Anxiety Self-Rating Scale (SAS) score and Self-Rating Depression Scale (SDS) score of the two groups of patients were decreased ∗ p < 0.05 , and the score of the observation group decreased more significantly p Δ < 0.05 . After nursing, the scores of the two groups of patients in social/family status, physical function, physiological function, and emotional status increased ∗ p < 0.05 , and the observation group was significantly higher than the control group p Δ < 0.05 . After nursing, the CD3+, CD4+, CD4+/CD8+ levels of the observation group were significantly higher than the control group p < 0.05 . The CD8+ level of the observation group was significantly lower than the control group p < 0.05 . After nursing, the levels of tumor markers in the two groups were decreased ∗ p < 0.05 , and the observation group was downregulated more significantly than the control group p Δ < 0.05 . The two-year cumulative survival rate of the observation group was 78.18%, and the two-year cumulative survival rate of the control group was 54.55%. The observation group was significantly higher than the control group p < 0.05 . Conclusions. Psychological intervention combined with dietary guidance can significantly improve the quality of life and mental state of patients with advanced ovarian cancer, enhance the patient’s immune function, reduce the serum tumor markers carcinoembryonic antigen (CEA) and carbohydrate antigen (CA199) levels, and improve survival rate and survival time, which has important clinical significance.

scholarly journals ION CHANGES IN BLOOD DURING OPISTHORCHIASIS IN EXPERIMENT

2019 ◽  
pp. 580-584
Author(s):  
Sidelnikova
Keyword(s):  
Ionic Composition ◽  
Venous Blood ◽  
Control Group ◽  
Observation Group ◽  
Arithmetic Average ◽  
Automated Hematology Analyzer ◽  
Ionic Imbalance ◽  
Quantitative Indicators ◽  
Sodium Plasma

Changes in the ionic composition of blood in opisthorchiasis, in the long-term inva-sion, is a current little-studied aspect. The experiment was conducted on rodents (rabbits), of puberty, male. Infection was carried out by oral administration of the metacercariae Opistorchis felineus at the rate of 50 larvae per individual (n = 10), defined in the observation group. The control group consisted of clinically healthy animals (n = 10). After 18 months, a biochemical blood test was performed to de-termine the quantitative indicators of potassium and sodium. Plasma isolation was performed by centrifuging venous blood, then incubated at room temperature for an hour, and the indicators were calculated using an automated hematology analyzer. Statistical data processing was performed using the software package Microsoft Of-fice Exel by calculating the arithmetic average with standard error of the mean. The analysis of intergroup data was carried out using the non-parametric Mann-Whitney U-test for unrelated aggregates with an abnormal distribution, with p ≤ 0.05.It is established that the content of potassium sharply exceeds the normal numerical criteria, the average amount of this ion is 6.932±0.772. When compared with the control, the differences are statistically significant (U = 0, p > 0.05). The amount of sodium in the observation group was 141.4±6.888, which falls within the range of normal values. When compared with the control, the differences are not statistically significant (U = 36, p > 0.05).Thus, when opisthorchiasis in the long-term invasion in rabbits in the experiment, an ionic imbalance is observed, with a predominance of potassium, with normal so-dium content. The established changes can be associated with impaired renal func-tion, angiopathy, general intoxication, provoked by the disease.

scholarly journals Long-Term Effect of Left Atrial Appendage Occlusion in Treating Patients with Previous Ischemic Stroke on the Disease Recurrence

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Jia Yu ◽  
Yufeng Liu ◽  
Peng Sun ◽  
Xing Guo ◽  
Haiyang Jiang ◽  
...  
Keyword(s):  
Left Atrial Appendage ◽  
Disease Recurrence ◽  
Term Effect ◽  
Control Group ◽  
Observation Group ◽  
Systemic Embolism ◽  
Exact Test ◽  
Left Atrial Appendage Occlusion ◽  
Long Term Effect

Background and Objective. Thrombolytics and anticoagulants are conventional drugs for ischemic stroke (IS) treatment, whereas some patients have unfavorable responses to these drugs. The disease presents a relatively high recurrence rate. This investigation attempted to unveil the long-term effect of left atrial appendage occlusion (LAAO) in treating patients with previous IS on the disease recurrence. Methods. A total of 120 patients with IS admitted to Tangdu Hospital from July 2016 to September 2017 were grouped into the control group ( n = 60 ) and the observation group ( n = 60 ). Patients in the control group were only treated with thrombolytics and anticoagulants while those in the observation group were treated with both drugs and LAAO. Transesophageal echocardiography (TEE) was performed to observe the occlusion of LAA in patients in the observation group after 45 d and 6 months, respectively. Clinical outcomes in two groups were compared from the following aspects: recurrence of IS, incidence of systemic embolism, and the 3-year recurrence-free survival (RFS). The 3-year IS recurrence of patients was compared by Fisher’s exact test. Results. No significant differences were observed at baseline levels (age, sex, etc.) between the observation group and control group ( p > 0.05 ). During follow-up visit of 45 d and 6 months, all occluders met the efficacious occludsion criteria. The results of TEE at 45 d after LAAO showed that 50% of patients (30/60) in the observation group had complete occlusion of LAA. The results of TEE at 6 months after LAAO suggested that 58.3% of patients (35/60) had complete occlusion of LAA. IS recurrence in the observation group (3.33%, 2/60) was significantly lower than that in the control group (18.33%, 11/60), with the difference presenting statistical significance ( p = 0.008 ). Incidence of systemic embolism in the observation group (1.67%, 1/60) was markedly lower than that in the control group (13.33%, 11/60) ( p = 0.014 ). The average RFS in the observation group (31.97 months, 95% CI: 27.50~32.31 months) was notably longer than that in the control group (29.91 months, 95% CI: 29.85~32.92 months) ( p < 0.05 ). The 3-year IS recurrence of patients between two groups compared by Fisher’s exact test showed significant differences (1 year: p = 0.014 , 2 year: p = 0.008 , 3 year: p = 0.008 ). Conclusion. Regarding patients with previous IS who had poor response to thrombolytics and anticoagulants, LAAO could effectively decrease recurrence of IS and incidence of systemic embolism and prolong RFS of patients. LAAO was, therefore, an alternative for patients with high IS recurrence risk.

Long Term and Low Dose Mifepristone in The Treatment of Uterine Leiomyoma

2021 ◽  
Vol 7 (5) ◽  
pp. 1681-1685
Author(s):  
Panpan Liu ◽  
Meifang Dou ◽  
Li’an Yi ◽  
Kemei Li ◽  
Fenghua Yan
Keyword(s):  
Uterine Leiomyoma ◽  
Adverse Reactions ◽  
Low Dose ◽  
Hot Flashes ◽  
Control Group ◽  
Observation Group ◽  
Conventional Dose ◽  
Long Term Effect ◽  
Significant Difference

To explore the long-term effect of low-dose mifepristone in the treatment of uterine leiomyoma. Methods: 90 cases of hysteromyoma treated in our hospital from December 2018 to May 2019 were randomly divided into control group and observation group, 45 cases in each group. The control group was treated with conventional dose (25mg / D) of mifepristone, and the observation group with low dose (12.5mg / D) of mifepristone. The uterine volume, uterine fibroid volume, hormone level, therapeutic effect and adverse reactions were compared between the two groups. Results: After treatment, the volume of uterus and hysteromyoma in the two groups decreased significantly, but there was no significant difference between the observation group and the control group (P > 0.05); the level of E2, P, FSH in the two groups decreased, but there was no significant difference between the observation group and the control group (P > 0.05); the treatment effect of the observation group and the control group was no significant difference (P > 0.05); the adverse reactions of nausea, anorexia, hot flashes and fatigue in the observation group The birth rate was significantly lower than that of the control group (P < 0.05). Conclusion: Low dose mifepristone can also effectively reduce the level of estrogen and progesterone in patients with uterine leiomyoma, reduce the volume of leiomyoma, reduce the incidence of adverse reactions, with high safety, which is worthy of clinical application.

scholarly journals Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma

2020 ◽  
Vol 36 (7) ◽  
Author(s):  
Xiaoxia Dai ◽  
Tao Feng ◽  
Xuejuan Zhang ◽  
Kaishu Li
Keyword(s):  
Symptom Score ◽  
Bronchial Asthma ◽  
Persistent Asthma ◽  
Inflammatory Factors ◽  
Control Group ◽  
Efficacy Rate ◽  
Observation Group ◽  
Creative Commons ◽  
The Difference ◽  
Open Access Article

Objective: To analyze the clinical effect of budesonide/fomoterol combined with montelukast in the treatment of chronic persistent asthma. Methods: Ninety-four patients with asthma who came to our hospital for treatment from April 2017 to April 2019 were randomly divided into control group and observation group, with 47 patients in each group. The control group was treated with budesonide/formoterol, and the observation group was treated with montelukast on the basis of the control group. The treatment effect of the two groups was observed and compared. Results: The total efficacy rate of the observation group was significantly higher than that of the control group (P<0.05); the daytime symptom score and nighttime symptom score of the observation group were significantly higher than those of the control group (P<0.05). The pulmonary function indexes of the two groups after treatment were significantly higher than that before treatment, and the improvement of the observation group was more significant (P<0.05); the FeNO and EO levels of the observation group after treatment were superior to those of the control group, and the difference was statistically significant (P<0.05). Conclusion: Budesonide/formoterol powder inhalation combined with montelukast can effectively improve the lung function, reduce the level of inflammatory factors, and accelerate the regression of symptoms in the treatment of chronic persistent asthma. It is worth clinical application. doi: https://doi.org/10.12669/pjms.36.7.2018 How to cite this:Dai X, Feng T, Zhang X, Li K. Budesonide/Fomoterol in combination with Montelukast in the treatment of Bronchial Asthma. Pak J Med Sci. 2020;36(7):---------. doi: https://doi.org/10.12669/pjms.36.7.2018 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Long-term clinical and radiographic outcomes of cervical disc replacement with the Prestige disc: results from a prospective randomized controlled clinical trial

2010 ◽  
Vol 13 (3) ◽  
pp. 308-318 ◽  
Author(s):  
J. Kenneth Burkus ◽  
Regis W. Haid ◽  
Vincent C. Traynelis ◽  
Praveen V. Mummaneni
Keyword(s):  
Clinical Outcomes ◽  
Surgical Procedures ◽  
Cervical Disc ◽  
Control Group ◽  
Segmental Motion ◽  
Disc Prosthesis ◽  
Treatment Groups ◽  
The Prestige

Object The purpose of this study was to determine long-term clinical outcomes in patients undergoing anterior cervical surgery in which a cervical disc prosthesis was used to treat single-level degenerative cervical disc disease. Methods In this prospective, nonblinded study, 541 patients at 32 investigational sites were randomly assigned to 1 of 2 treatment groups. The results of the investigational group, in which patients received the Prestige disc prosthesis, were compared with those of the control group, in which patients underwent an instrumented interbody fusion. Data were collected preoperatively, intraoperatively, and at 1.5, 3, 6, 12, 24, 36, and 60 months postoperatively. To date, 271 patients have completed 5 years of clinical follow-up (144 investigational and 127 control patients). Results Significant improvements in Neck Disability Index (NDI) scores, Physical Component Summary scores of the 36-Item Short-Form Health Survey, and neck and arm pain scores were achieved by 1.5 months in both groups and sustained at 5 years. The mean NDI improvements from preoperative scores were 35.4, 36.3, and 38.4 at 24, 36, and 60 months, respectively, in the investigational group. The corresponding mean NDI improvements were 33.9, 31.3, and 34.1 in the control group. The intergroup differences at both 36 and 60 months were significant (p = 0.008 and 0.022, respectively). The overall rates of maintenance or improvement in neurological status in the investigational group were 91.6%, 92.8%, and 95.0%, respectively, at 24, 36, and 60 months compared with 83.6%, 83.2%, and 88.9% in the control group (p = 0.006, 0.004, and 0.051, respectively). The implant effectively maintained angular motion, averaging more than 7.3° at 36 months and 6.5° at 60 months after surgery. No implant migration was observed up to 60 months. There were statistically significant differences between the investigational and control groups with regard to the rate of revision and supplemental fixation surgical procedures performed subsequent to the index procedure. Additional surgical procedures for adjacent-segment disease were observed in both treatment groups. Rates for surgery at adjacent levels trended lower in the investigational group (8 patients [11 surgeries]) compared with those in the control group (13 patients [16 surgeries]), but the differences were not statistically significant (p = 0.376). Some of the second surgeries involved both index and adjacent levels. Conclusions The Prestige disc maintains improved clinical outcomes and segmental motion after implantation at 5-year follow-up.

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