scholarly journals Impact of Xpert MTB/RIF and decentralized care on linkage to care and drug-resistant tuberculosis treatment outcomes in Johannesburg, South Africa

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Denise Evans ◽  
Tembeka Sineke ◽  
Kathryn Schnippel ◽  
Rebecca Berhanu ◽  
Caroline Govathson ◽  
...  
Keyword(s):  
South Africa ◽  
Treatment Outcomes ◽  
Linkage To Care ◽  
Tuberculosis Treatment ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Decentralized Care

scholarly journals Cost outcome analysis of decentralized care for drug-resistant tuberculosis in Johannesburg, South Africa

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0217820 ◽  
Author(s):  
Craig van Rensburg ◽  
Rebecca Berhanu ◽  
Kamban Hirasen ◽  
Denise Evans ◽  
Sydney Rosen ◽  
...  
Keyword(s):  
South Africa ◽  
Outcome Analysis ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Decentralized Care

scholarly journals Ambulatory Multi-Drug Resistant Tuberculosis Treatment Outcomes in a Cohort of HIV-Infected Patients in a Slum Setting in Mumbai, India

PLoS ONE ◽  
2011 ◽  
Vol 6 (12) ◽  
pp. e28066 ◽  
Author(s):  
Petros Isaakidis ◽  
Helen S. Cox ◽  
Bhanumati Varghese ◽  
Chiara Montaldo ◽  
Esdras Da Silva ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Tuberculosis Treatment ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis ◽  
Multi Drug Resistant Tuberculosis

scholarly journals ‘Out of sight, out of mind?’ A follow-up on HIV-infected patients with drug-resistant pulmonary tuberculosis in Uganda: A case series

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110197
Author(s):  
Marco Notarfrancesco ◽  
Barbara Castelnuovo ◽  
Marisa Kaelin ◽  
Jan Fehr ◽  
Christine Sekaggya-Wiltshire
Keyword(s):  
Treatment Outcomes ◽  
Case Series ◽  
Tuberculosis Treatment ◽  
World Health ◽  
People Living With Hiv ◽  
Close Monitoring ◽  
Drug Resistant ◽  
Drug Resistant Tuberculosis ◽  
Resistant Tuberculosis

Among new tuberculosis cases in Uganda, 10.3% are drug-resistant and 43% occur in people living with HIV. Both resistance and HIV–tuberculosis co-infection lead to unfavourable tuberculosis treatment outcomes. In this case series, we followed up eight HIV–tuberculosis co-infected patients withdrawn from a pharmacokinetics study on anti-tuberculosis drugs between April 2013 and April 2015 following a diagnosis of drug-resistant tuberculosis. We identified resistance patterns and treatment regimens and evaluated their tuberculosis treatment outcomes. Two patients were multidrug-resistant, only one out of eight was treated according to the World Health Organization guidelines applicable at that time and five had unfavourable tuberculosis treatment outcomes, that is, were lost to follow-up, could not be evaluated or died. Taken together, we found unfavourable tuberculosis treatment outcomes for patients with drug-resistant tuberculosis. This indicates the necessity of implementation of current treatment guidelines and close monitoring for patients with drug-resistant tuberculosis.

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