scholarly journals Association between whole grain intake and breast cancer risk: a systematic review and meta-analysis of observational studies

2018 ◽  
Vol 17 (1) ◽  
Author(s):  
Yunjun Xiao ◽  
Yuebin Ke ◽  
Shuang Wu ◽  
Suli Huang ◽  
Siguo Li ◽  
...  
PLoS ONE ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. e0229899 ◽  
Author(s):  
Menglin Li ◽  
Mei Han ◽  
Zijie Chen ◽  
Yu Tang ◽  
Jie Ma ◽  
...  

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Delphine Praud ◽  
Floriane Deygas ◽  
Amina Amadou ◽  
Federica Turati ◽  
Francesca Bravi ◽  
...  

2005 ◽  
Vol 23 (34) ◽  
pp. 8606-8612 ◽  
Author(s):  
Stefanos Bonovas ◽  
Kalitsa Filioussi ◽  
Nikolaos Tsavaris ◽  
Nikolaos M. Sitaras

Purpose A growing body of evidence suggests that statins may have chemopreventive potential against breast cancer. Laboratory studies demonstrate that statins induce apoptosis and reduce cell invasiveness in various cell lines, including breast carcinoma cells. However, the clinical relevance of these data remains unclear. The nonconclusive nature of the epidemiologic data prompted us to conduct a detailed meta-analysis of the studies published on the subject in peer-reviewed literature. Patients and Methods A comprehensive search for articles published up until 2005 was performed; reviews of each study were conducted; and data were abstracted. Before meta-analysis, the studies were evaluated for publication bias and heterogeneity. Pooled relative risk (RR) estimates and 95% CIs were calculated using the random and the fixed-effects models. Subgroup and sensitivity analyses were also performed. Results Seven large randomized trials and nine observational studies (five case-control and four cohort studies) contributed to the analysis. We found no evidence of publication bias or heterogeneity among the studies. Statin use did not significantly affect breast cancer risk (fixed effects model: RR = 1.03; 95% CI, 0.93 to 1.14; random effects model: RR = 1.02; 95% CI, 0.89 to 1.18). When the analyses were stratified into subgroups, there was no evidence that study design substantially influenced the estimate of effects. Furthermore, the sensitivity analysis confirmed the stability of our results. Conclusion Our meta-analysis findings do not support a protective effect of statins against breast cancer. However, this conclusion is limited by the relatively short follow-up times of the studies analyzed. Further studies are required to investigate the potential decrease in breast cancer risk among long-term statin users.


2015 ◽  
Vol 17 (1) ◽  
Author(s):  
Heleen K Bronsveld ◽  
Bas ter Braak ◽  
Øystein Karlstad ◽  
Peter Vestergaard ◽  
Jakob Starup-Linde ◽  
...  

2017 ◽  
Vol 34 (2) ◽  
pp. e2961 ◽  
Author(s):  
Rui Du ◽  
Lin Lin ◽  
Di Cheng ◽  
Yu Xu ◽  
Min Xu ◽  
...  

2019 ◽  
Vol Volume 11 ◽  
pp. 593-603 ◽  
Author(s):  
Yupeng Liu ◽  
Xiaosan Zhang ◽  
Hongru Sun ◽  
Shu Zhao ◽  
Yuxue Zhang ◽  
...  

2020 ◽  
Vol 128 (1) ◽  
pp. 016002 ◽  
Author(s):  
Troy W. R. Hiller ◽  
Dylan E. O’Sullivan ◽  
Darren R. Brenner ◽  
Cheryl E. Peters ◽  
Will D. King

2014 ◽  
Vol 110 (9) ◽  
pp. 2327-2338 ◽  
Author(s):  
P Chen ◽  
C Li ◽  
X Li ◽  
J Li ◽  
R Chu ◽  
...  

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