scholarly journals Prenatal and early childhood exposure to tetrachloroethylene (PCE)-contaminated drinking water and sleep quality in adulthood: a retrospective cohort study

2022 ◽  
Vol 21 (1) ◽  
Author(s):  
Charlotte R. Doran ◽  
Ann Aschengrau
Keyword(s):  
Drinking Water ◽  
Sleep Quality ◽  
Early Life ◽  
Cape Cod ◽  
Short Sleep Duration ◽  
Short Sleep ◽  
Early Life Exposure ◽  
Contaminated Drinking Water ◽  
Risk Ratios

Abstract Background Communities in Cape Cod, Massachusetts were exposed to tetrachloroethylene (PCE) through contaminated drinking water from 1969 to 1983. PCE exposure during adulthood has well-established neurotoxic effects; however, long-term impacts stemming from early life exposure, especially adverse effects on sleep quality, are not well understood. Methods The present analysis was based on data from the Cape Cod Health Study, a retrospective cohort study of the long-term neurotoxic impacts of early-life exposure to PCE-contaminated drinking water. Exposure to PCE-contaminated water was estimated using a validated leaching and transport model. Measures of sleep quality were obtained from self-administered questionnaires. Generalized estimating equations were used to generate risk ratios and 95% confidence intervals to estimate the association between early-life PCE exposure and sleep quality among 604 participants. Results Compared to unexposed participants, any PCE exposure during early life was associated with 1.57 times the risk of reporting breathing pauses during sleep (95% CI 0.92–2.68). Low-level exposure to PCE was associated with 1.50 times the risk of reporting sleep apnea or other sleep disorders (95% CI 0.78–2.89), while high levels of exposure had comparable risk compared to no exposure (RR = 0.94, 95% CI 0.50–1.79). Weak or no associations were observed for other sleep quality outcomes. In stratified analyses participants with mental illness and/or substance use disorder had increased risk ratios for short sleep duration associated with PCE exposure. Conclusion These findings suggest that early-life exposure to PCE may be associated with a moderate increase in the risk of reporting breathing pauses during sleep in adulthood and that a history of mental illness and/or substance use disorder may exacerbate the risk of short sleep duration.

scholarly journals Long-term Neurotoxic Effects of Early-life Exposure to Tetrachloroethylene-contaminated Drinking Water

2016 ◽  
Vol 82 (1) ◽  
pp. 169 ◽  
Author(s):  
Ann Aschengrau ◽  
Patricia A. Janulewicz ◽  
Roberta F. White ◽  
Veronica M. Vieira ◽  
Lisa G. Gallagher ◽  
...  
Keyword(s):  
Drinking Water ◽  
Early Life ◽  
Early Life Exposure ◽  
Neurotoxic Effects ◽  
Contaminated Drinking Water

scholarly journals No Association Between Unintentional Head Injuries and Early-Life Exposure to Tetrachloroethylene (PCE)-Contaminated Drinking Water

2016 ◽  
Vol 58 (10) ◽  
pp. 1040-1045 ◽  
Author(s):  
Ann Aschengrau ◽  
Lisa G. Gallagher ◽  
Michael R. Winter ◽  
Veronica M. Vieira ◽  
Patricia A. Janulewicz ◽  
...  
Keyword(s):  
Drinking Water ◽  
Early Life ◽  
Head Injuries ◽  
Early Life Exposure ◽  
Contaminated Drinking Water

scholarly journals Sleep Duration and Sleep Quality Are Associated with Physical Activity in Elderly People Living in Nursing Homes

2018 ◽  
Vol 15 (11) ◽  
pp. 2512 ◽  
Author(s):  
Lovro Štefan ◽  
Goran Vrgoč ◽  
Tomislav Rupčić ◽  
Goran Sporiš ◽  
Damir Sekulić
Keyword(s):  
Physical Activity ◽  
Nursing Homes ◽  
Sleep Quality ◽  
Sleep Duration ◽  
Short Sleep Duration ◽  
Cross Sectional ◽  
Elderly Individuals ◽  
Short Sleep ◽  
Long Sleep ◽  
Good Sleep

The main purpose of the study was to explore the associations of sleep duration and sleep quality with physical activity (PA). In this cross-sectional study, participants were 894 elderly individuals (mean age 80 ± 3 years; 56.0% women) living in nursing homes. PA, sleep duration, and sleep quality (based on the Pittsburgh Sleep Quality Index (PSQI)) were self-reported. The associations of sleep duration and sleep quality with PA at the nursing home level were analyzed using generalized estimating equations with clustering. Participants reporting short sleep duration (<6 h; OR = 0.45; 95% CI 0.25–0.80) were less likely to report sufficient PA, yet those reporting long sleep duration (>9 h; OR = 2.61; 95% CI 1.35–5.02) and good sleep quality (<5 points; OR = 1.59; 95% CI 1.19–2.12) were more likely to report sufficient PA. When sleep duration and sleep quality were entered into the same model, the same associations remained. This study shows that elderly individuals who report short sleep duration are less likely to meet PA guidelines, while those who report long sleep duration and good sleep quality are more likely to meet PA guidelines. Strategies aiming to improve sleep duration and sleep quality are warranted.

Abstract P336: The Association Between Goal-Striving Stress, Sleep Duration and Sleep Quality in the Jackson Heart Study

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Loretta Cain ◽  
LáShauntá Glover ◽  
Dayna Johnson ◽  
Mario Sims
Keyword(s):  
Sleep Quality ◽  
Sleep Duration ◽  
Poor Sleep ◽  
Jackson Heart Study ◽  
Poor Sleep Quality ◽  
Short Sleep Duration ◽  
Logistic Regression Models ◽  
Short Sleep ◽  
Goal Striving ◽  
Heart Study

Introduction: Research shows that compared to non-Hispanic whites, African Americans (AAs) have poorer sleep quality, lower mean sleep duration, and a higher prevalence of sleep-disordered breathing. AAs also report more frequent exposures to certain stressors over the life course, which may impact physiological processes that may impair sleep. Goal-striving-stress (GSS), the discrepancy between aspiration and achievement, weighted by the subjective probability of success, and the level of disappointment experienced if goals are not reached, may be an important stressor among AA’s that may influence sleep; however this has yet to be explored. The objective of this study was to assess the relationship between GSS and sleep duration and sleep quality in AAs. Hypothesis: We assessed the hypothesis that high (versus low) GSS would be associated with short or long sleep duration and poor sleep quality. Methods: We utilized data from the baseline exam of the Jackson Heart Study (JHS; n=5306), an AA sample of women and men, 35-84 years old. There were a total of 5082 participants in the sample; 63.34% female with a mean age of 55.30 (± 12.75) and mean sleep duration of 6.43 hours (±1.51). The sample was categorized into GSS tertiles: low (n=2121), moderate (n=1716), high (n=1296). Participants self-reported sleep duration (hours) and rated their sleep quality. Sleep duration was categorized as short ( < 6 hours), normal (7 or 8 hours) and long ( > 9 hours). Sleep quality was categorized as high (good/very good/excellent) and low (fair/poor). Logistic regression models were used to obtain odds ratios (OR, 95% confidence interval-CI) to assess the associations of GSS levels with sleep duration and sleep quality categories. Models were adjusted for sex, age, socioeconomic status, health behaviors, discrimination, and health outcomes. Results: Significant results showed that participants who reported high (versus low) GSS had a 29% increased odds [1.29 (1.10, 1.52)] of short (versus normal) sleep after full adjustment. Participants who reported high (versus low) GSS had a 42% increased odds [1.42 (1.20, 1.67)] of low (versus high) sleep quality after full adjustment. Conclusion In conclusion, the deficit between goal aspiration and achievement is associated with short sleep duration and poor sleep quality. Potential interventions should consider the extent to which GSS may contribute to the development of short sleep duration and poor sleep quality.

scholarly journals Drug use disorder following early life exposure to tetrachloroethylene (PCE)-contaminated drinking water: a retrospective cohort study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Ann Aschengrau ◽  
Alexandra Grippo ◽  
Michael R. Winter ◽  
Margaret G. Shea ◽  
Roberta F. White ◽  
...  
Keyword(s):  
Early Childhood ◽  
Drinking Water ◽  
Cohort Study ◽  
Drug Use ◽  
Diagnostic Criteria ◽  
Retrospective Cohort Study ◽  
Early Life ◽  
Retrospective Cohort ◽  
Contaminated Drinking Water ◽  
Drug Use Disorder

Abstract Background Many studies of adults with occupational exposure to solvents such as tetrachloroethylene (PCE) have shown adverse effects on cognition, mood and behavioral problems. Much less is known about neurotoxic effects in early life at lower exposure levels seen in community settings. We recently reported that illicit drug use was more frequent among adults from Cape Cod, Massachusetts who were exposed to PCE-contaminated drinking water during gestation and early childhood than their unexposed counterparts. Using newly collected data from this population-based retrospective cohort study, the current analysis examines whether early life PCE exposure is also associated with drug use disorder over the life course. Methods Three-hundred and sixty-three subjects with prenatal and early childhood PCE exposure and 255 unexposed subjects were studied. These individuals (median age: 40–41 years) completed self-administered questionnaires on the eleven established diagnostic criteria for drug use disorder and confounding variables. A validated leaching and transport model was used to estimate exposure to PCE-contaminated water. Results Overall, 23.3% of subjects reported having at least one criterion for drug use disorder over their lifetime. Early life PCE exposure was associated with a modest increase in the lifetime presence of one or more diagnostic criteria for drug use disorder (adjusted RR: 1.4, 95% CI: 1.0–1.8). Compared to unexposed subjects, PCE-exposed subjects were more likely to report having most diagnostic criteria of drug use disorder, including neglecting major roles due to drug use, physical and psychological problems related to drug use, and giving up activities due to drug use. No dose-response relationships were observed with increasing levels of PCE exposure. Conclusions These results suggest that exposure to PCE-contaminated drinking water during early life modestly increases the risk of developing diagnostic criteria for drug use disorder later in life. Because this study has several limitations, these findings should be confirmed in follow-up investigations of other exposed populations with more diverse racial and socioeconomic characteristics.

Early-life exposure to lithium and boron from drinking water

2012 ◽  
Vol 34 (4) ◽  
pp. 552-560 ◽  
Author(s):  
Florencia Harari ◽  
Ana María Ronco ◽  
Gabriela Concha ◽  
Miguel Llanos ◽  
Margaretha Grandér ◽  
...  
Keyword(s):  
Drinking Water ◽  
Early Life ◽  
Early Life Exposure

Early-life exposure to lithium in drinking water and infant thyroid function.

2016 ◽  
Vol 2016 (1) ◽  
Author(s):  
Florencia Harari* ◽  
Anna Karin Bernhardsson ◽  
Brita Palm ◽  
Esperanza Casimiro ◽  
Ying Lu ◽  
...  
Keyword(s):  
Drinking Water ◽  
Thyroid Function ◽  
Early Life ◽  
Early Life Exposure
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