Targeting of the AXL receptor tyrosine kinase by small molecule inhibitor leads to AXL cell surface accumulation by impairing the ubiquitin-dependent receptor degradation

Molecule Inhibitor ◽

Axl Receptor Tyrosine Kinase

Abstract B027: BGB324, a selective small molecule inhibitor of AXL receptor tyrosine kinase, enhances immune checkpoint inhibitor efficacy

10.1158/2326-6066.imm2016-b027 ◽

2016 ◽

Author(s):

Katarzyna Wnuk-Lipinska ◽

Kjersti Davidsen ◽

Magnus Blø ◽

Linn Hodneland ◽

Agnete Engelsen ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Immune Checkpoint ◽

Checkpoint Inhibitor ◽

Molecule Inhibitor ◽

Axl Receptor Tyrosine Kinase

Abstract 566: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

10.1158/1538-7445.am2016-566 ◽

2016 ◽

Cited By ~ 4

Author(s):

Gro Gausdal ◽

Kjersti Davidsen ◽

Katarzyna Wnuk-Lipinska ◽

Kathleen Wiertel ◽

Jing Kang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Immune Checkpoint ◽

Checkpoint Inhibitor ◽

Abstract 626: BGB324, a selective small molecule inhibitor of receptor tyrosine kinase AXL, abrogates tumor intrinsic and microenvironmental immune suppression and enhances immune checkpoint inhibitor efficacy in lung and mammary adenocarcinoma models

10.1158/1538-7445.am2017-626 ◽

2017 ◽

Cited By ~ 4

Author(s):

Katarzyna Wnuk-Lipinska ◽

Kjersti Davidsen ◽

Magnus Blø ◽

Agnete Engelsen ◽

Jing Kang ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Immune Suppression ◽

Immune Checkpoint ◽

Checkpoint Inhibitor ◽

Mammary Adenocarcinoma ◽

Abstract B014: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy

10.1158/2326-6074.cricimteatiaacr15-b014 ◽

2016 ◽

Cited By ~ 1

Author(s):

Gro Gausdal ◽

Kjersti Davidsen ◽

Katarzyna Wnuk-Lipinska ◽

Kathleen Wiertel ◽

Monica Hellesøy ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Immune Checkpoint ◽

Checkpoint Inhibitor ◽

563 POSTER SGX126: a novel, potent and highly selective small molecule inhibitor of the c-Met receptor tyrosine kinase

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(08)72497-2 ◽

2008 ◽

Vol 6 (12) ◽

pp. 177

Author(s):

S. Buchanan ◽

K. Jessen ◽

C. Tang ◽

S. Sperry ◽

C. Smith ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Met Receptor ◽

Met Receptor Tyrosine Kinase ◽

Abstract P2-04-08: BGB324, a selective small molecule inhibitor of the receptor tyrosine kinase AXL, enhances immune checkpoint inhibitor efficacy in mammary adenocarcinoma

10.1158/1538-7445.sabcs16-p2-04-08 ◽

2017 ◽

Author(s):

JB Lorens ◽

KW Lipinska ◽

K Davidsen ◽

M Blø ◽

L Hodneland ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Immune Checkpoint ◽

Checkpoint Inhibitor ◽

Mammary Adenocarcinoma ◽

Antitumor Activity of GSK1904529A, a Small-molecule Inhibitor of the Insulin-like Growth Factor-I Receptor Tyrosine Kinase

Clinical Cancer Research ◽

10.1158/1078-0432.ccr-08-2530 ◽

2009 ◽

Vol 15 (9) ◽

pp. 3058-3067 ◽

Cited By ~ 50

Author(s):

Peter Sabbatini ◽

Jason L. Rowand ◽

Arthur Groy ◽

Susan Korenchuk ◽

Qi Liu ◽

...

Keyword(s):

Growth Factor ◽

Antitumor Activity ◽

Tyrosine Kinase ◽

Small Molecule ◽

Insulin Like Growth Factor ◽

Factor I ◽

Molecule Inhibitor ◽

Growth Factor I

Preclinical analysis of the analinoquinazoline AG1478, a specific small molecule inhibitor of EGF receptor tyrosine kinase

Biochemical Pharmacology ◽

10.1016/j.bcp.2006.01.020 ◽

2006 ◽

Vol 71 (10) ◽

pp. 1422-1434 ◽

Cited By ~ 52

Author(s):

A.G. Ellis ◽

M.M. Doherty ◽

F. Walker ◽

J. Weinstock ◽

M. Nerrie ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Egf Receptor ◽

Abstract 3774: BGB324, a selective small-molecule inhibitor of receptor tyrosine kinase AXL, targets tumor immune suppression and enhances immune checkpoint inhibitor efficacy

10.1158/1538-7445.am2018-3774 ◽

2018 ◽

Cited By ~ 1

Author(s):

Kjersti Davidsen ◽

Katarzyna Wnuk-Lipinska ◽

Wenting Du ◽

Magnus Blø ◽

Agnete Engelsen ◽

...

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Immune Suppression ◽

Immune Checkpoint ◽

Checkpoint Inhibitor ◽

560 POSTER Discovery and preclinical characterization of BMS-777607: a potent, small molecule inhibitor of Met receptor tyrosine kinase

European Journal of Cancer Supplements ◽

10.1016/s1359-6349(08)72494-7 ◽

2008 ◽

Vol 6 (12) ◽

pp. 176

Author(s):

R. Borzilleri ◽

J. Fargnoli

Keyword(s):

Tyrosine Kinase ◽

Small Molecule ◽

Met Receptor ◽

Met Receptor Tyrosine Kinase ◽