scholarly journals Traditional Chinese medicine for anti-Alzheimer’s disease: berberine and evodiamine from Evodia rutaecarpa

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zhiling Fang ◽  
Yuqing Tang ◽  
Jiaming Ying ◽  
Chunlan Tang ◽  
Qinwen Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Evodia Rutaecarpa

Acupuncture plus Herbal Medicine for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 45 (07) ◽  
pp. 1327-1344 ◽  
Author(s):  
Simin Zhou ◽  
Lanlan Dong ◽  
Yuan He ◽  
Hong Xiao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
World Population ◽  
Chinese Herbal ◽  
Significant Difference

Alzheimer’s disease (AD) is associated with the unprecedented aging tendency in our world population and has become a significant health issue. The use of Traditional Chinese Medicine to treat AD has been increasing in recent years. The objective of this meta-analysis is to evaluate the effectiveness of combining acupuncture with herbal medicine to treat AD. Randomized controlled trials (RCTs) of acupuncture plus herbals versus treatment with western drugs for AD were retrieved from 11 databases. The data were extracted by two authors; dichotomous data were expressed as odds ratio (ORs) and 95% confidence intervals (CIs), while continuous data were calculated by mean differences (MDs) with 95% CIs. Although the combined analysis of the score of Activity of Daily Life (ADL) scale MD was [Formula: see text]3.59 (95% CI [Formula: see text]7.18–0.01, [Formula: see text]), which indicates there was no statistically significant difference between the two treatments at reducing the ADL scale score, the pooled results of 12 trials indicated that acupuncture plus Chinese herbal medicine was better than western drugs at improving the effectiveness rate (OR 2.24, 95% CI 1.40–3.56), the combined evidence of 11 articles showed that acupuncture plus Chinese herbal medicine was more effective than western drugs at improving the scores for the Mini Mental State Examination (MMSE) scale (2.10, 95% CI 0.69–3.51, [Formula: see text]) and the traditional Chinese medicine symptom (MD 5.07, 95% CI 3.90–6.25, [Formula: see text]). From the current research results, acupuncture plus herbal medicine may have advantages over western drugs for treating AD. Nevertheless, well-designed RCTs with a larger sample size are required in the future.

Anti-acetylcholinesterase activities of traditional Chinese medicine for treating Alzheimer's disease

2008 ◽  
Vol 175 (1-3) ◽  
pp. 352-354 ◽  
Author(s):  
H.Q. Lin ◽  
Michelle T. Ho ◽  
Lesley S. Lau ◽  
Kelvin K. Wong ◽  
P.C. Shaw ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine

scholarly journals History and Experience: A Survey of Traditional Chinese Medicine Treatment for Alzheimer's Disease

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Ping Liu ◽  
Mingwang Kong ◽  
Shihe Yuan ◽  
Junfeng Liu ◽  
Ping Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Chinese Herb ◽  
Herbal Medicines ◽  
Single Target ◽  
Cognitive Benefits ◽  
Target Regulation ◽  
Chinese Medicine Treatment

Traditional Chinese medicine (TCM) is practiced in the Chinese health care system for more than 2,000 years. In recent years, herbal medicines, which are used to treat Alzheimer's disease (AD) in China based on TCM or modern pharmacological theories have attracted considerable attention. In this paper, we discuss etiology and pathogenesis of AD, TCM therapy, and herbal extracts for the treatment of AD. There is evidence to suggest that TCM therapy may offer certain complementary cognitive benefits for the treatment of AD. Chinese herb may have advantages with multiple target regulation compared with the single-target antagonist in view of TCM.

scholarly journals Ligand-Based and Structure-Based Investigation for Alzheimer’s Disease from Traditional Chinese Medicine

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Kai Hsin Liao ◽  
Kuen-Bao Chen ◽  
Wen-Yuan Lee ◽  
Mao-Feng Sun ◽  
Cheng-Chun Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Amyloid Beta ◽  
Complex Structure ◽  
Hydrocarbon Chain ◽  
Tau Proteins ◽  
Structure Stability ◽  
Ligand Interaction

Alzheimer’s disease is a neurodegenerative disease that was conventionally thought to be related to the sedimentation of beta-amyloids, but drugs designed according to this hypothesis have generally failed. That FKBP52 can reduce the accumulation of tau proteins, and that Tacrolimus can reduce the pathological changes of tau proteins are new directions away from the long held amyloid-beta-centric concept. Therefore, the screening of traditional Chinese medicine compounds for those with higher affinity towards FKBP52 than Tacrolimus may be a new direction for treating Alzheimer’s disease. This study utilizes ligand-based and structure-based methods as the foundation. By utilizing dock scores and the predicted pIC50 from SVM, MLR, and Bayesian Network, several TCM compounds were selected for further analysis of their protein-ligand interactions. Daphnetoxin has higher affinity and complex structure stability than Tacrolimus; Lythrancine II exhibits the most identical trends in FKBP52 interactions as Tacrolimus, and 20-O-(2′E,4′E-decadienoyl)ingenol may be further modified at its hydrocarbon chain to promote interaction with FKBP52. In addition, we observed the residue Tyr113 of FKBP52 may play a key role in protein-ligand interaction. Our results indicate that Daphnetoxin, 20-O-(2′E,4′E-decadienoyl)ingenol, and Lythrancine II may be starting points for further modification as a new type of non-amyloid-beta-centric drug for Alzheimer’s disease.

scholarly journals ALZHEIMER’S DISEASE TREATMENT WITH TRADITIONAL CHINESE MEDICINE

2020 ◽  
Vol 7 (10) ◽  
pp. 448-451
Author(s):  
Jihe Zhu ◽  
Blagica Arsovska ◽  
Kristina Kozovska
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Ginkgo Biloba ◽  
Neurodegenerative Disorder ◽  
Health Condition ◽  
Significant Loss ◽  
Gingko Biloba ◽  
Kidney Yang Deficiency

Alzheimer’s disease is a brain neurodegenerative disorder, which is characterized with coordinative and cognitive dysfunctions with significant loss of memory. By the terms of Traditional Chinese Medicine (TCM) the Alzheimer’s disease may occur because of: spleen or liver Qi deficiency with phlegm, spleen and kidney yang deficiency, Qi and blood stagnations and others. With the use of Ginkgo biloba the stagnated energy, the excretion of the mucus and blocked blood can be mobilized and the blood circulation can be promoted to the brain. This study includes 5 patients, 4 women and 1 man, aged from 55 to 78. All patients have the disease for more than 2 years and main symptom in all is dementia. All patients have done certain number of acupuncture treatment and were prescribed Ginkgo biloba 1g per day. After starting the treatment all patients have stated that their health condition is improved, their memory is better and are feeling warmth and circulation to the head and neck. For a chronic and lifetime disease like Alzheimer’s, the treatment with Gingko Biloba is also for lifetime and it is shown to be successful in its aim to slow down the progression of the disease and release the symptoms.

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