scholarly journals Weight loss and bone mineral density in obese adults: a longitudinal analysis of the influence of very low energy diets

2018 ◽  
Vol 4 (1) ◽  
Author(s):  
Palak Choksi ◽  
Amy Rothberg ◽  
Andrew Kraftson ◽  
Nicole Miller ◽  
Katherine Zurales ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Bone Mineral ◽  
Longitudinal Analysis ◽  
Low Energy ◽  
Mineral Density ◽  
Obese Adults

Low Energy Availability, Menstrual Dysfunction, and Low Bone Mineral Density in Individuals with a Disability: Implications for the Para Athlete Population

2017 ◽  
Vol 47 (9) ◽  
pp. 1697-1708 ◽  
Author(s):  
Cheri A. Blauwet ◽  
Emily M. Brook ◽  
Adam S. Tenforde ◽  
Elizabeth Broad ◽  
Caroline H. Hu ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Low Energy ◽  
Energy Availability ◽  
Mineral Density ◽  
Menstrual Dysfunction ◽  
Low Bone Mineral Density ◽  
Low Energy Availability

Genetically determined SCFA concentration modifies the association of dietary fiber intake with changes in bone mineral density during weight loss: The Preventing Overweight Using Novel Dietary Strategies (POUNDS LOST) trial

2021 ◽  
Author(s):  
Tao Zhou ◽  
Dianjianyi Sun ◽  
Xiang Li ◽  
Yoriko Heianza ◽  
Meryl S LeBoff ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Dietary Fiber ◽  
Bone Mineral ◽  
Genetic Variants ◽  
Whole Body ◽  
Fiber Intake ◽  
Mineral Density ◽  
Dietary Fiber Intake ◽  
Dietary Strategies

ABSTRACT Background SCFAs are involved in regulation of body weight and bone health. Objectives We aimed to examine whether genetic variations related to butyrate modified the relation between dietary fiber intake and changes in bone mineral density (BMD) in response to weight-loss dietary interventions. Methods In the 2-y Preventing Overweight Using Novel Dietary Strategies trial, 424 participants with BMD measured by DXA scan were randomly assigned to 1 of 4 diets varying in macronutrient intakes. A polygenic score (PGS) was calculated based on 7 genetic variants related to the production of butyrate for 370 of the 424 participants. Results SCFA PGS significantly modified the association between baseline dietary fiber intake and sex on 2-y changes in whole-body BMD (P-interaction = 0.049 and 0.008). In participants with the highest tertile of SCFA PGS, higher dietary fiber intake was related to a greater increase in BMD (β:  0.0022; 95% CI: 0.0009, 0.0035; P = 0.002), whereas no such association was found for participants in the lower tertiles. In the lowest tertiles of SCFA PGS, men showed a significant increase in whole-body BMD (β: 0.0280; 95% CI: 0.0112, 0.0447; P = 0.002) compared with women. In the highest tertile, no significant difference was found for the change in BMD between men and women. Conclusions Our data indicate that genetic variants related to butyrate modify the relations of dietary fiber intake and sex with long-term changes in BMD in response to weight-loss diet interventions.

scholarly journals Weight loss since early adulthood, later life risk of fracture hospitalizations, and bone mineral density: a prospective cohort study of 0.5 million Chinese adults

2020 ◽  
Vol 15 (1) ◽  
Author(s):  
Zewei Shen ◽  
◽  
Canqing Yu ◽  
Yu Guo ◽  
Zheng Bian ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Weight Loss ◽  
Hip Fracture ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Early Adulthood ◽  
Broadband Ultrasound Attenuation ◽  
Later Life ◽  
Mineral Density

Abstract Summary In a Chinese population from both urban and rural areas, weight loss of ≥ 5 kg from early adulthood to midlife was associated with a higher risk of hip fracture and lower BMD in later life. Introduction This study investigates the association of the long-term weight loss from young adulthood through the middle ages with the subsequent 10-year risk of hospitalized fracture and calcaneus bone mineral density (BMD). Methods China Kadoorie Biobank (CKB) was established during 2004–2008 in ten areas across China. Weight at age 25 years was self-reported at baseline, and weight at baseline and resurvey was measured by the calibrated equipment. Outcomes were hospitalized fracture during follow-up and calcaneus BMD measured at resurvey. Analysis for fracture risk included 411,812 participants who were free of fracture in the last 5 years before baseline, cancer, or stroke at any time before baseline. Analysis for BMD included 21,453 participants who participated in the resurvey of 2013–2014 with the same exclusion criteria as above. Results The mean age was 50.8 at baseline and 58.4 at resurvey. Median weight change from age 25 to baseline was 4.4 kg, with 20.7% losing weight and 58.5% gaining weight. During a median follow-up of 10.1 years, we documented 13,065 cases of first diagnosed fracture hospitalizations, including 1222 hip fracture. Compared with participants whose weight was stable (± 2.4 kg), the adjusted hazard ratios (95% CIs) for those with weight loss of ≥ 5.0 kg from age 25 to baseline was 1.39 (1.17 to 1.66) for hip fracture. Weight loss was not associated with fracture risk at other sites. Those with weight loss from age 25 to resurvey had the lowest BMD measures, with β (95% CIs) of − 4.52 (− 5.08 to − 3.96) for broadband ultrasound attenuation (BUA), − 4.83 (− 6.98, − 2.67) for speed of sound (SOS), and − 4.36 (− 5.22, − 3.49) for stiffness index (SI). Conclusions Weight loss from early adulthood to midlife was associated with a higher risk of hip fracture and lower BMD in later life.

scholarly journals Effects of obesity treatments on bone mineral density, bone turnover and fracture risk in adults with overweight or obesity

2016 ◽  
Vol 28 (3) ◽  
Author(s):  
Claudia Harper ◽  
Andrea L. Pattinson ◽  
Hamish A. Fernando ◽  
Jessica Zibellini ◽  
Radhika V. Seimon ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bariatric Surgery ◽  
Weight Loss ◽  
Bone Turnover ◽  
Fracture Risk ◽  
Bone Mineral ◽  
Dietary Restriction ◽  
Mineral Density ◽  
Pre Treatment ◽  
Obesity Treatments

AbstractBackground:New evidence suggests that obesity is deleterious for bone health, and obesity treatments could potentially exacerbate this.Materials and methods:This narrative review, largely based on recent systematic reviews and meta-analyses, synthesizes the effects on bone of bariatric surgery, weight loss pharmaceuticals and dietary restriction.Results and conclusions:All three obesity treatments result in statistically significant reductions in hip bone mineral density (BMD) and increases in bone turnover relative to pre-treatment values, with the reductions in hip BMD being strongest for bariatric surgery, notably Roux-en Y gastric bypass (RYGB, 8%–11% of pre-surgical values) and weakest for dietary restriction (1%–1.5% of pre-treatment values). Weight loss pharmaceuticals (orlistat or the glucagon-like peptide-1 receptor agonist, liraglutide) induced no greater changes from pre-treatment values than control, despite greater weight loss. There is suggestive evidence that liraglutide may increase bone mineral content (BMC) – but not BMD – and reduce fracture risk, but more research is required to clarify this. All three obesity treatments have variable effects on spine BMD, probably due to greater measurement error at this site in obesity, suggesting that future research in this field could focus on hip rather than spine BMD. Various mechanisms have been proposed for BMD loss with obesity treatments, notably reduced nutritional intake/absorption and insufficient exercise, and these are potential avenues for protection against bone loss. However, a pressing outstanding question is whether this BMD reduction contributes to increased fracture risk, as has been observed after RYGB, and whether any such increase in fracture risk outweighs the risks of staying obese (unlikely).

scholarly journals Bone metabolism, bone mineral density and low-energy fractures 10 years after Roux-en-Y gastric bypass

Bone ◽  
2019 ◽  
Vol 127 ◽  
pp. 436-445 ◽  
Author(s):  
Ingvild Kristine Blom-Høgestøl ◽  
Stephen Hewitt ◽  
Monica Chahal-Kummen ◽  
Cathrine Brunborg ◽  
Hanne Løvdal Gulseth ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Gastric Bypass ◽  
Bone Metabolism ◽  
Bone Mineral ◽  
Low Energy ◽  
Mineral Density

scholarly journals Exercise training in obese older adults prevents increase in bone turnover and attenuates decrease in hip bone mineral density induced by weight loss despite decline in bone-active hormones

2011 ◽  
Vol 26 (12) ◽  
pp. 2851-2859 ◽  
Author(s):  
Krupa Shah ◽  
Reina Armamento-Villareal ◽  
Nehu Parimi ◽  
Suresh Chode ◽  
David R Sinacore ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Weight Loss ◽  
Exercise Training ◽  
Bone Turnover ◽  
Bone Mineral ◽  
Mineral Density

scholarly journals Effects of analgesics on bone mineral density: A longitudinal analysis of the prospective SWAN cohort with three-group matching weights

2017 ◽  
Vol 27 (2) ◽  
pp. 182-190 ◽  
Author(s):  
Kazuki Yoshida ◽  
Zhi Yu ◽  
Gail A. Greendale ◽  
Kristine Ruppert ◽  
Yinjuan Lian ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Bone Mineral ◽  
Longitudinal Analysis ◽  
Mineral Density ◽  
Group Matching

scholarly journals Change in Bone Mineral Density During Weight Loss with Resistance Versus Aerobic Exercise Training in Older Adults

2017 ◽  
Vol 72 (11) ◽  
pp. 1582-1585 ◽  
Author(s):  
Kristen M Beavers ◽  
Daniel P Beavers ◽  
Sarah B Martin ◽  
Anthony P Marsh ◽  
Mary F Lyles ◽  
...  
Keyword(s):  
Bone Mineral Density ◽  
Older Adults ◽  
Weight Loss ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Bone Mineral ◽  
Aerobic Exercise Training ◽  
Mineral Density
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