Urbanicity and risk of first-episode psychosis: incidence study in Brazil

2019 ◽  
Vol 215 (6) ◽  
pp. 726-729 ◽  
Author(s):  
Cristina Marta Del-Ben ◽  
Rosana Shuhama ◽  
Camila Marcelino Loureiro ◽  
Taciana Cristina Carvalho Ragazzi ◽  
Daniela Perocco Zanatta ◽  
...  
Keyword(s):  
At Risk ◽  
First Episode Psychosis ◽  
Incidence Rates ◽  
First Episode ◽  
World Population ◽  
Middle Income ◽  
Middle Income Countries ◽  
Episode Psychosis ◽  
Gender And Age ◽  
Lower Population

We estimated the incidence of first-episode psychosis over a 3-year period in a Brazilian catchment area comprising the region's main city, Ribeirão Preto (1 425 306 persons-years at risk), and 25 other municipalities with a total of 1 646 556 persons-years at risk. The incidence rates were estimated and adjusted by gender and age, using the direct standardisation method to the world population as reference. The incidence of psychosis was higher in the younger groups, men, and among Black and minority ethnic Brazilians. Psychosis incidence was lower in Ribeirão Preto (16.69/100 000 person-years at risk; 95% CI 15.68–17.70) compared with the average incidence in the remaining municipalities (21.25/100 000 person-years at risk; 95% CI 20.20–22.31), which have lower population density, suggesting a distinct role for urbanicity in the incidence of first-episode psychosis in low- and middle-income countries.

scholarly journals Incidence of first-contact psychosis in São Paulo, Brazil

2007 ◽  
Vol 191 (S51) ◽  
pp. s102-s106 ◽  
Author(s):  
Paulo R. Menezes ◽  
Marcia Scazufca ◽  
Geraldo F. Busatto ◽  
Letícia M. S. Coutinho ◽  
Philip K. Mcguire ◽  
...  
Keyword(s):  
At Risk ◽  
Census Data ◽  
First Episode Psychosis ◽  
Sao Paulo ◽  
First Episode ◽  
São Paulo ◽  
Middle Income ◽  
Middle Income Countries ◽  
Episode Psychosis ◽  
First Contact

BackgroundLittle is known about the incidence of first-episode psychosis in urban centres of low- or middle-income countriesAimsTo estimate the incidence of psychosis in São Paulo, a large metropolis of BrazilMethodProspective survey of first-episode psychosis among residents aged 18–64 years resident in a defined area of São Paulo, over a 30-month period (July 2002- December 2004). Assessments were carried out with the SCID–I, and diagnoses given according to DSM – IV criteria. Population at risk was drawn from the 2000 Census dataResultsThere were 367 first-episode cases identified (51% women), and almost 40% fulfilled criteria for schizophrenia or schizophreniform disorder. The incidence rate for any psychosis was 15.8/100 000 person-years at risk (95% CI 14.3–17.6). Incidence of non-affective psychoses was higher among younger malesConclusionsIncidence of psychosis in São Paulo was lower than expected for a large metropolis

scholarly journals Grey matter abnormalities in Brazilians with first-episode psychosis

2007 ◽  
Vol 191 (S51) ◽  
pp. s117-s122 ◽  
Author(s):  
Maristela S. Schaufelberger ◽  
Fabio L. S. Duran ◽  
Julia M. Lappin ◽  
Marcia Scazufca ◽  
Edson Amaro ◽  
...  
Keyword(s):  
Grey Matter ◽  
First Episode Psychosis ◽  
High Income ◽  
First Episode ◽  
Voxel Based Morphometry ◽  
Middle Income ◽  
Middle Income Countries ◽  
Episode Psychosis ◽  
Structural Abnormalities ◽  
The Right

BackgroundIn low-and middle-income countries people with schizophrenia are reported to experience better outcomes than those in high-income countriesAimsTo examine structural brain differences in people with first-episode psychosis and controls in BrazilMethodMagnetic resonance imaging using voxel-based morphometry was performed on 122 people with first-episode psychosis and 94 controlsResultsThere were significant decreases in grey matter in the left superior temporal and inferior prefrontal cortices, insula bilaterally and the right hippocampal region in first-episode psychosis (P<0.05, corrected for multiple comparisons). The subgroup of people with schizophrenia (n=62) exhibited a similar pattern of decrease in grey matter relative to controlsConclusionsStructural abnormalities reported in psychosis in high-income countries are also present in first-episode psychosis in Brazil

scholarly journals Circulating lipids associate with future weight gain in individuals with an at-risk mental state and in first-episode psychosis

2020 ◽  
Author(s):  
Santosh Lamichhane ◽  
Alex M. Dickens ◽  
Partho Sen ◽  
Heikki Laurikainen ◽  
Jaana Suvisaari ◽  
...  
Keyword(s):  
At Risk ◽  
Weight Gain ◽  
High Risk ◽  
Psychotic Disorders ◽  
First Episode Psychosis ◽  
Molecular Signature ◽  
First Episode ◽  
Baseline Serum ◽  
Average Life Span ◽  
Episode Psychosis

AbstractPatients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic co-morbidities. Identification of individuals with psychotic disorders with a high risk of rapid weight gain, and the associated development of metabolic complications, is an unmet need as regards public health. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 controls (CTR), 44 first-episode psychosis (FEP) patients and 22 individuals at clinical-high-risk (CHR) for psychosis, from two study centers (Turku/Finland and London/UK). Baseline serum samples were analyzed by lipidomics, while body mass index (BMI) was assessed at baseline and after 12 months. We found that baseline triacylglycerols with low double bond counts and carbon numbers were positively associated with the change in BMI at follow-up. In addition, a molecular signature comprised of two triacylglycerols (TG(48:0) and TG(45:0)), was predictive of weight gain in individuals with a psychotic disorder, with an area under the receiver operating characteristic curve (AUROC) of 0.74 (95% CI: 0.60–0.85). When independently tested in the CHR group, this molecular signature predicted said weight change with AUROC = 0.73 (95% CI: 0.61–0.83). We conclude that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals, and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic co-morbidities.

scholarly journals Book Reviews: CBT for Those at Risk of a First Episode Psychosis: evidence-based psychotherapy for people with an “At Risk Mental State” – Erratum

2015 ◽  
Vol 43 (3) ◽  
pp. 384-384
Author(s):  
C. Collinson
Keyword(s):  
At Risk ◽  
First Episode Psychosis ◽  
Clinical Psychologist ◽  
First Episode ◽  
Evidence Based ◽  
Episode Psychosis ◽  
Evidence Based Psychotherapy ◽  
At Risk Mental State

Please note the author of this book review is Dr Catherine Campbell, Clinical Psychologist, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, and not Collinson, C. (2015) as cited in the original article. The book review editors extend their sincere apologies to Dr Campbell for this error.

Poster #40 LONGITUDINAL HEMODYNAMIC CHANGES AND PREDICTION OF FUNCTIONAL OUTCOME IN AT-RISK MENTAL STATE AND FIRST-EPISODE PSYCHOSIS

2012 ◽  
Vol 136 ◽  
pp. S199-S200
Author(s):  
Shinsuke Koike ◽  
Yoshihiro Satomura ◽  
Yukika Nishimura ◽  
Yosuke Takano ◽  
Norichika Iwashiro ◽  
...  
Keyword(s):  
At Risk ◽  
Functional Outcome ◽  
Mental State ◽  
First Episode Psychosis ◽  
First Episode ◽  
Hemodynamic Changes ◽  
Episode Psychosis ◽  
At Risk Mental State

scholarly journals Criticism and Depression among the Caregivers of At-Risk Mental State and First-Episode Psychosis Patients

PLoS ONE ◽  
2016 ◽  
Vol 11 (2) ◽  
pp. e0149875 ◽  
Author(s):  
Yumiko Hamaie ◽  
Noriyuki Ohmuro ◽  
Masahiro Katsura ◽  
Chika Obara ◽  
Tatsuo Kikuchi ◽  
...  
Keyword(s):  
At Risk ◽  
Mental State ◽  
First Episode Psychosis ◽  
First Episode ◽  
Episode Psychosis ◽  
At Risk Mental State

scholarly journals Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis

2020 ◽  
Author(s):  
Santosh Lamichhane ◽  
Alex M Dickens ◽  
Partho Sen ◽  
Heikki Laurikainen ◽  
Faith Borgan ◽  
...  
Keyword(s):  
At Risk ◽  
Weight Gain ◽  
High Risk ◽  
Psychotic Disorders ◽  
First Episode Psychosis ◽  
Molecular Signature ◽  
First Episode ◽  
Baseline Serum ◽  
Average Life Span ◽  
Episode Psychosis

Abstract Patients with schizophrenia have a lower than average life span, largely due to the increased prevalence of cardiometabolic comorbidities. There is an unmet public health need to identify individuals with psychotic disorders who have a high risk of rapid weight gain and who are at risk of developing metabolic complications. Here, we applied mass spectrometry-based lipidomics in a prospective study comprising 48 healthy controls (CTR), 44 first-episode psychosis (FEP) patients, and 22 individuals at clinical high risk (CHR) for psychosis, from 2 study centers (Turku, Finland and London, UK). Baseline serum samples were analyzed using lipidomics, and body mass index (BMI) was assessed at baseline and after 12 months. We found that baseline triacylglycerols (TGs) with low double-bond counts and carbon numbers were positively associated with the change in BMI at follow-up. In addition, a molecular signature comprised of 2 TGs (TG[48:0] and TG[45:0]) was predictive of weight gain in individuals with a psychotic disorder, with an area under the receiver operating characteristic curve (AUROC) of 0.74 (95% CI: 0.60–0.85). When independently tested in the CHR group, this molecular signature predicted said weight change with AUROC = 0.73 (95% CI: 0.61–0.83). We conclude that molecular lipids may serve as a predictor of weight gain in psychotic disorders in at-risk individuals and may thus provide a useful marker for identifying individuals who are most prone to developing cardiometabolic comorbidities.

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