scholarly journals Serum levels of P-selectin in men with high-functioning autism

2008 ◽  
Vol 193 (4) ◽  
pp. 338-339 ◽  
Author(s):  
Yasuhide Iwata ◽  
Kenji J. Tsuchiya ◽  
Sumiko Mikawa ◽  
Kazuhiko Nakamura ◽  
Yoshifumi Takai ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
High Functioning Autism ◽  
Immune Dysfunction ◽  
Serum Levels ◽  
Soluble Form ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
High Functioning ◽  
Selectin Family ◽  
Spectrum Disorders

SummaryImmune dysfunction has been proposed as a mechanism for the pathophysiology of autistic-spectrum disorders. The selectin family of adhesion molecules plays a prominent role in immune/inflammatory responses. We determined the serum levels of three types of soluble-form selectin (sP, sL and sE) in 15 men with high-functioning autism and 22 age-matched healthy controls by enzyme-linked immunosorbent assay. Levels of sP-selectin and sL-selectin were significantly lower in patients than in controls. Furthermore, sP-selectin levels were negatively correlated with impaired social development during early childhood.

scholarly journals Do social attribution skills improve with age in children with high functioning autism spectrum disorders?

2013 ◽  
Vol 7 (1) ◽  
pp. 9-16 ◽  
Author(s):  
Elgiz Bal ◽  
Benjamin E. Yerys ◽  
Jennifer L. Sokoloff ◽  
Mark J. Celano ◽  
Lauren Kenworthy ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
High Functioning Autism ◽  
Autism Spectrum ◽  
High Functioning ◽  
Social Attribution ◽  
Spectrum Disorders

scholarly journals Anti-phosphatidylserine/prothrombin Complex Antibodies in Patients With Cutaneous Vasculitis: Possible Involvement in the Pathogenesis

2020 ◽  
Author(s):  
Yuto Tamura ◽  
Tamihiro Kawakami ◽  
Yupeng Dong ◽  
Miku Yoshinari ◽  
Yuka Nishibata ◽  
...  
Keyword(s):  
Vascular Endothelium ◽  
Systemic Vasculitis ◽  
Serum Levels ◽  
Cutaneous Vasculitis ◽  
Enzyme Linked Immunosorbent Assay ◽  
Healthy Controls ◽  
Iga Vasculitis ◽  
Skin Involvement ◽  
Wild Type ◽  
Significant Difference

Abstract Objective. It was previously demonstrated that cutaneous vasculitis, including IgA vasculitis and cutaneous arteritis (CA), is associated with the presence of IgM antibodies (Abs) against the phosphatidylserine/prothrombin complex (PS/PT). Recently, novel enzyme-linked immunosorbent assay kits for the detection of IgG and IgM anti-PS/PT (aPS/PT) Abs have become commercially available.Methods. The prevalence of serum IgG and IgM aPS/PT Abs in both cutaneous and systemic vasculitis was determined using these kits. In addition, to examine whether aPS/PT Abs were involved in the pathogenesis of cutaneous vasculitis, inbred wild-type rats were intravenously administered with a rat IgM class aPS/PT monoclonal Ab established previously or with rat immunoglobulins as controls. To express PS on the surface of vascular endothelium, these rats were given a subcutaneous injection of cell-free histones (250 µg/ml, 300 µl/site) 2 hours in advance. Results. Serum IgM aPS/PT Ab levels were elevated in patients with systemic vasculitis with skin involvement and CA compared to those in patients with systemic vasculitis without skin involvement and healthy controls. There was no significant difference in the serum levels of IgG aPS/PT Abs between the patients and healthy controls. Correspondingly, inbred wild-type rats intravenously administered with the aPS/PT monoclonal IgM Ab after appropriate priming—subcutaneous histone injection—developed cutaneous vasculitis. Some rats given rat IgM instead of the aPS/PT monoclonal Ab also developed cutaneous vasculitis, whereas vasculitis did not occur in rats given IgG or only priming by histones. Conclusion. IgM aPS/PT Abs could be involved in the pathogenesis of cutaneous vasculitis.

Comparison of Saliva Collection Methods in Children with High-Functioning Autism Spectrum Disorders: Acceptability and Recovery of Cortisol

2012 ◽  
Vol 43 (4) ◽  
pp. 560-573 ◽  
Author(s):  
Susan K. Putnam ◽  
Christopher Lopata ◽  
Jeffery D. Fox ◽  
Marcus L. Thomeer ◽  
Jonathan D. Rodgers ◽  
...  
Keyword(s):  
Autism Spectrum Disorders ◽  
High Functioning Autism ◽  
Autism Spectrum ◽  
High Functioning ◽  
Saliva Collection ◽  
Spectrum Disorders ◽  
Collection Methods

Health-Related Quality of Life of Parents of Children With High-Functioning Autism Spectrum Disorders

2009 ◽  
Vol 24 (4) ◽  
pp. 227-239 ◽  
Author(s):  
Gloria K. Lee ◽  
Christopher Lopata ◽  
Martin A. Volker ◽  
Marcus L. Thomeer ◽  
Robert E. Nida ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Autism Spectrum Disorders ◽  
High Functioning Autism ◽  
Autism Spectrum ◽  
Health Related Quality ◽  
High Functioning ◽  
Related Quality ◽  
Health Related ◽  
Spectrum Disorders
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