Should psychiatrists be prescribing oestrogen therapy to their female patients?

SummarySome studies have indicated that oestrogen therapy may be beneficial in the treatment of a number of neuropsychiatric disorders. However, it has been suggested that psychiatrists fail to prescribe oestrogen therapy to their patients, as they are ‘not aware of or ‘do not believe’ studies supporting their use. This paper reappraises the putative role of hormone treatments, particularly oestrogen therapy, in psychiatry.

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The putative role of oxidative stress and inflammation in the pathophysiology of sleep dysfunction across neuropsychiatric disorders: Focus on chronic fatigue syndrome, bipolar disorder and multiple sclerosis

Sleep Medicine Reviews ◽

10.1016/j.smrv.2018.03.007 ◽

2018 ◽

Vol 41 ◽

pp. 255-265 ◽

Cited By ~ 30

Author(s):

Gerwyn Morris ◽

Brendon Stubbs ◽

Cristiano A. Köhler ◽

Ken Walder ◽

Anastasiya Slyepchenko ◽

...

Keyword(s):

Oxidative Stress ◽

Multiple Sclerosis ◽

Bipolar Disorder ◽

Chronic Fatigue Syndrome ◽

Neuropsychiatric Disorders ◽

Chronic Fatigue ◽

Sleep Dysfunction ◽

Fatigue Syndrome ◽

Putative Role

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FEEDBACK CONTROL OF FSH IN THE MALE: ROLE OF OESTROGEN

Acta Endocrinologica ◽

10.1530/acta.0.0740449 ◽

1973 ◽

Vol 74 (3) ◽

pp. 449-460 ◽

Cited By ~ 11

Author(s):

Patrick C. Walsh ◽

Ronald S. Swerdloff ◽

William D. Odell

Keyword(s):

Luteinizing Hormone ◽

Follicle Stimulating Hormone ◽

Oestrogen Therapy ◽

Serum Concentrations ◽

Elderly Men ◽

Normal Range ◽

Oestrogen Treatment ◽

Serum Lh ◽

Higher Doses

ABSTRACT Serum follicle stimulating hormone (FSH) and luteinizing hormone (LH) were measured by radioimmunoassay in a group of elderly men following castration and oestrogen therapy. Prior to orchiectomy, mean serum concentrations of LH and FSH were within the normal range. Two days following castration, serum LH concentrations increased in all eight patients; higher levels of LH were subsequently measured in all but one patient after periods of time ranging from 49 to 210 days. Serum FSH levels, measured in three patients following castration, increased in a pattern parallel to LH changes. Ethinyl oestradiol (EOe) in doses ranging from 5 to 300 μg/day was administered to ten men who had been castrated 3 to 72 months earlier. Oestrogen treatment suppressed both LH and FSH in a parellel manner in nine of ten patients. LH was first suppressed to intact levels in one of eight patients treated with 20 μg/day of EOe, in two of six patients treated with 50 μg/day, and in one patient by 80 μg/day. FSH was not suppressed to precastration levels until 50 μg/day of EOe was administered; this dose suppressed three of six patients. Higher doses of EOe (150–300 μg/day) suppressed both LH and FSH to levels below the sensitivity of the assay. These data fail to demonstrate any differential effect of oestrogen on LH and FSH release.

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Putative role of Lateral Habenula projections to Dorsal Raphe Nucleus in encoding for depression-like behaviour and abnormal circadian rhythms.

10.26226/morressier.5b31ec482afeeb001345b44a ◽

2018 ◽

Author(s):

Dipesh Chaudhury ◽

He Liu

Keyword(s):

Circadian Rhythms ◽

Dorsal Raphe Nucleus ◽

Dorsal Raphe ◽

Raphe Nucleus ◽

Lateral Habenula ◽

Putative Role ◽

Dorsal Raphé

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Gut Microbiota and Antipsychotics Induced Metabolic Alteration

Global Clinical and Translational Research ◽

10.36316/gcatr.01.0020 ◽

2019 ◽

pp. 131-143

Author(s):

Dong-Yu Kan ◽

Su-Juan Li ◽

Chen-Chen Liu ◽

Ren-Rong Wu

Keyword(s):

Gut Microbiota ◽

Body Weight Gain ◽

Neuropsychiatric Disorders ◽

Elevated Risk ◽

Metabolic Disturbance ◽

Metabolic Dysfunction ◽

Sequencing Technology ◽

Severe Mental Disorder ◽

Metabolic Alteration

Schizophrenia is a chronic and severe mental disorder with antipsychotics as primary medications, but the antipsychotic-induced metabolic side effects may contribute to the elevated risk of overall morbidity and mortality in patients with psych-iatric diseases. With the development in sequencing technology and bioinformatics, dysbiosis has been shown to contribute to body weight gain and metabolic dysfunction. However, the role of gut microbiota in the antipsychotic-induced metabolic alteration remains unknown. In this paper, we reviewed the recent studies of the gut microbiota with psychiatric disorders and antipsychotic-induced metabolic dysfunction. Patients with neuropsychiatric disorders may have a different composi-tion of gut microbiota compared with healthy controls. In addition, it seems that the use of antipsychotics is concurrently associated with both altered composition of gut microbiota and metabolic disturbance. Further study is needed to address the role of gut microbiota in the development of neuropsychiatric disorders and antipsychotic-induced metabolic disturbance, to develop novel therapeutics for both neuropsychiatric disorders and metabolic dysfunction.

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The Role of Neurohypophyseal Hormones Vasopressin and Oxytocin in Neuropsychiatric Disorders

Endocrine Metabolic & Immune Disorders - Drug Targets ◽

10.2174/1871530318666180220104900 ◽

2018 ◽

Vol 18 (4) ◽

pp. 341-347 ◽

Cited By ~ 14

Author(s):

Michele Iovino ◽

Tullio Messana ◽

Giovanni De Pergola ◽

Emanuela Iovino ◽

Franca Dicuonzo ◽

...

Keyword(s):

Neuropsychiatric Disorders ◽

Neurohypophyseal Hormones

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Importance of Apolipoprotein A-I and A-II Composition in HDL and Its Potential for Studying COVID-19 and SARS-CoV-2

Medicines ◽

10.3390/medicines8070038 ◽

2021 ◽

Vol 8 (7) ◽

pp. 38

Author(s):

Kyung-Hyun Cho

Keyword(s):

Antiviral Activity ◽

High Density ◽

High Density Lipoproteins ◽

Potent Antiviral Activity ◽

Apolipoprotein A ◽

Putative Role

The composition and properties of apolipoprotein (apo) A-I and apoA-II in high-density lipoproteins (HDL) might be critical to SARS-CoV-2 infection via SR-BI and antiviral activity against COVID-19. HDL containing native apoA-I showed potent antiviral activity, while HDL containing glycated apoA-I or other apolipoproteins did not. However, there has been no report to elucidate the putative role of apoA-II in the antiviral activity of HDL.

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