scholarly journals Monitoring electrocardiograms of service users on high-dose methadone substitution therapy: an audit

2010 ◽  
Vol 34 (11) ◽  
pp. 489-491
Author(s):  
Soumya Ghosh ◽  
Anil Kodagalli ◽  
Faiz Bhatti ◽  
Timothy Bradbeer
Keyword(s):  
High Dose ◽  
Service Users ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Substitution Therapy ◽  
Care Services ◽  
Department Of Health ◽  
Simple Tool ◽  
Qtc Interval Prolongation ◽  
Electrocardiogram Ecg

Aims and methodTo explore the extent to which 2007 Department of Health guidelines on monitoring of high-dose (⩾100 mg) methadone were followed, the reasons for non-adherence to these and the prevalence of QTc prolongation. We developed a simple tool for collecting data from case notes.ResultsOut of 25 service users, 11 had had an electrocardiogram (ECG) and 7 had evidence of requests sent to general practitioners. After implementation of our recommendations, ten more service users had ECGs within 1 month. All but one ECG was normal. Methadone prescribing in favour of lower doses has been observed. QTc interval prolongation was not common.Clinical implicationsEffective communication between primary and secondary care services is important in identifying cases and arranging ECGs.

QTc interval prolongation with high dose energy drink consumption in a healthy volunteer

2014 ◽  
Vol 172 (2) ◽  
pp. e336-e337 ◽  
Author(s):  
Sachin A. Shah ◽  
Carolyn S. Lacey ◽  
Taylor Bergendahl ◽  
Mark Kolasa ◽  
Ian C. Riddock
Keyword(s):  
Healthy Volunteer ◽  
Energy Drink ◽  
High Dose ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Qtc Interval Prolongation ◽  
Energy Drink Consumption

scholarly journals Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Mille K. Lyhne ◽  
Andreas Vegge ◽  
Gro Klitgaard Povlsen ◽  
Rita Slaaby ◽  
Jonas Kildegaard ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Fold Increase ◽  
Diabetic Group ◽  
Large Animal ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Hyperinsulinaemic Hypoglycaemia ◽  
Large Animal Models ◽  
Qtc Interval Prolongation ◽  
Electrocardiographic Recordings

AbstractThe potentially fatal cardiovascular effects of hypoglycaemia are not well understood and large animal models of the counter-regulatory responses and cardiovascular consequences of insulin-induced hypoglycaemia are needed to understand the mechanisms in humans. The aim of this study was to develop a human-like minipig model of hypoglycaemia including healthy and diabetic pigs to investigate endocrine, electrocardiographic and platelet effects. Hypoglycaemia was induced using a hyperinsulinaemic, hypoglycaemic clamp and an insulin bolus protocol. Plasma glucose, glucagon, C-peptide, insulin, epinephrine and platelet aggregation responses were measured before, during and after hypoglycaemia. Continuous electrocardiographic recordings were obtained. Hypoglycaemia at a plasma glucose concentration of 0.8–1.0 mM in the clamp induced 25-fold increase in epinephrine and sixfold and threefold increase in glucagon for healthy and diabetic pigs, respectively. The hypoglycaemic clamp induced QTc-interval prolongation and increase in cardiac arrhythmias. In the bolus approach, the non-diabetic group reached plasma glucose target of 1.5 mM and QTc-interval was prolonged after insulin injection, but before glucose nadir. The diabetic group did not reach hypoglycaemic target, but still demonstrated QTc-interval prolongation. These results demonstrate effects of hyperinsulinaemic hypoglycaemia closely resembling human physiology, indicating the minipig as a translational animal model of counter-regulatory endocrine and myocardial effects of hypoglycaemia.

QTc interval prolongation in systemic sclerosis: Correlations with clinical variables

2015 ◽  
Vol 182 ◽  
pp. 20-22 ◽  
Author(s):  
E. Rosato ◽  
A. Gigante ◽  
M. Liberatori ◽  
M.L. Gasperini ◽  
L. Sardo ◽  
...  
Keyword(s):  
Systemic Sclerosis ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Clinical Variables ◽  
Qtc Interval Prolongation

Possible association of QTc interval prolongation with co-administration of quetiapine and lovastatin

2002 ◽  
Vol 51 (3) ◽  
pp. 264-265 ◽  
Author(s):  
Benjamin A. Furst ◽  
Katherine M. Champion ◽  
Joseph M. Pierre ◽  
Donna A. Wirshing ◽  
William C. Wirshing
Keyword(s):  
Qtc Interval ◽  
Interval Prolongation ◽  
Qtc Interval Prolongation

Drug-induced QTc interval prolongation: A proposal towards an efficient and safe anticancer drug development

2008 ◽  
Vol 44 (4) ◽  
pp. 494-500 ◽  
Author(s):  
Giuseppe Curigliano ◽  
Gianluca Spitaleri ◽  
Howard J. Fingert ◽  
Filippo de Braud ◽  
Cristiana Sessa ◽  
...  
Keyword(s):  
Drug Development ◽  
Anticancer Drug ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Drug Induced ◽  
Qtc Interval Prolongation ◽  
Anticancer Drug Development

QTc interval prolongation in children with Turner syndrome: the results of exercise testing and 24-h ECG

2008 ◽  
Vol 168 (1) ◽  
pp. 59-64 ◽  
Author(s):  
Robert Dalla Pozza ◽  
Susanne Bechtold ◽  
Simon Urschel ◽  
Heinrich Netz ◽  
Hans-Peter Schwarz
Keyword(s):  
Turner Syndrome ◽  
Exercise Testing ◽  
Qtc Interval ◽  
Interval Prolongation ◽  
Qtc Interval Prolongation

Translating the gap in the evaluation of drug-induced QTc-interval prolongation from in vivo to the clinic

2014 ◽  
Vol 70 (3) ◽  
pp. 324
Author(s):  
Vincent F.S. Dubois ◽  
Piet van der Graaf ◽  
Derek Leishman ◽  
David Gallacher ◽  
Nick McMahon ◽  
...  
Keyword(s):  
Qtc Interval ◽  
Interval Prolongation ◽  
Drug Induced ◽  
Qtc Interval Prolongation
Sign in / Sign up

Export Citation Format

Share Document