scholarly journals Biliary lipids and cholesterol gallstone disease

2008 ◽  
Vol 50 (Supplement) ◽  
pp. S406-S411 ◽  
Author(s):  
David Q-H. Wang ◽  
David E. Cohen ◽  
Martin C. Carey
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Biliary Lipids

scholarly journals Hepatic cholesterol metabolism in cholesterol gallstone disease

1991 ◽  
Vol 32 (3) ◽  
pp. 469-475
Author(s):  
E Reihnér ◽  
B Angelin ◽  
I Björkhem ◽  
K Einarsson
Keyword(s):  
Cholesterol Metabolism ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Hepatic Cholesterol

Impaired human gallbladder lipid absorption in cholesterol gallstone disease and its effect on cholesterol solubility in bile

2000 ◽  
Vol 118 (5) ◽  
pp. 912-920 ◽  
Author(s):  
Stefano Ginanni Corradini ◽  
Walter Elisei ◽  
Luca Giovannelli ◽  
Cristina Ripani ◽  
Paola Della Guardia ◽  
...  
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Lipid Absorption ◽  
Human Gallbladder ◽  
Cholesterol Solubility

scholarly journals Quantitative trait loci mapping for cholesterol gallstones in AKR/J and C57L/J strains of mice

2000 ◽  
Vol 4 (1) ◽  
pp. 59-65 ◽  
Author(s):  
BEVERLY PAIGEN ◽  
NICHOLAS J. SCHORK ◽  
KAREN L. SVENSON ◽  
YIN-CHAI CHEAH ◽  
JIAN-LONG MU ◽  
...  
Keyword(s):  
Quantitative Trait ◽  
Congenic Strain ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Gallstone Formation ◽  
Quantitative Trait Loci Mapping ◽  
Cholesterol Gallstones ◽  
Lithogenic Diet ◽  
The Difference ◽  
Trait Locus

Quantitative trait locus (QTL) mapping was used to locate genes that determine the difference in cholesterol gallstone disease between the gallstone-susceptible strain C57L/J and the gallstone-resistant strain AKR/J. Gallstone weight was determined in 231 male (AKR × C57L) F1× AKR backcross mice fed a lithogenic diet containing 1% cholesterol, 0.5% cholic acid, and 15% butterfat for 8 wk. Mice having no stones and mice having the largest stones were genotyped at ∼20-cM intervals to find the loci determining cholesterol gallstone formation. The major locus, Lith1, mapped near D2Mit56 and was confirmed by constructing a congenic strain, AK.L- Lith1s. Another locus, Lith2, mapped near D19Mit58 and was also confirmed by constructing a congenic strain AK.L- Lith2s. Other suggestive, but not statistically significant, loci mapped to chromosomes 6, 7, 8, 10, and X. The identification of these Lith genes will elucidate the pathophysiology of cholesterol gallstone formation.

scholarly journals The Role of Diet in the Pathogenesis of Cholesterol Gallstones

2019 ◽  
Vol 26 (19) ◽  
pp. 3620-3638 ◽  
Author(s):  
Agostino Di Ciaula ◽  
Gabriella Garruti ◽  
Gema Frühbeck ◽  
Maria De Angelis ◽  
Ornella de Bari ◽  
...  
Keyword(s):  
Vitamin C ◽  
Fast Food ◽  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Gallstone Formation ◽  
Protective Role ◽  
Cholesterol Homeostasis ◽  
Major Health Problem ◽  
Cholesterol Gallstones ◽  
Beneficial Effects

: Cholesterol gallstone disease is a major health problem in Westernized countries and depends on a complex interplay between genetic factors, lifestyle and diet, acting on specific pathogenic mechanisms. Overweigh, obesity, dyslipidemia, insulin resistance and altered cholesterol homeostasis have been linked to increased gallstone occurrence, and several studies point to a number of specific nutrients as risk- or protective factors with respect to gallstone formation in humans. There is a rising interest in the identification of common and modifiable dietetic factors that put the patients at risk of gallstones or that are able to prevent gallstone formation and growth. In particular, dietary models characterized by increased energy intake with highly refined sugars and sweet foods, high fructose intake, low fiber contents, high fat, consumption of fast food and low vitamin C intake increase the risk of gallstone formation. On the other hand, high intake of monounsaturated fats and fiber, olive oil and fish (ω-3 fatty acids) consumption, vegetable protein intake, fruit, coffee, moderate alcohol consumption and vitamin C supplementation exert a protective role. : The effect of some confounding factors (e.g., physical activity) cannot be ruled out, but general recommendations about the multiple beneficial effects of diet on cholesterol gallstones must be kept in mind, in particular in groups at high risk of gallstone formation.

scholarly journals Association of caveolin-3 and cholecystokinin A receptor with cholesterol gallstone disease in mice

2014 ◽  
Vol 20 (28) ◽  
pp. 9513-9518 ◽  
Author(s):  
Guo-Qiang Xu ◽  
Cheng-Fu Xu ◽  
Hong-Tan Chen ◽  
Shan Liu ◽  
Xiao-Dong Teng ◽  
...  
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Disease

scholarly journals An update on the pathogenesis of cholesterol gallstone disease

2018 ◽  
Vol 34 (2) ◽  
pp. 71-80 ◽  
Author(s):  
Agostino Di Ciaula ◽  
David Q.-H. Wang ◽  
Piero Portincasa
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Disease

Evidence for the role of amerindian ancestry as a risk factor for cholesterol gallstone disease in chile

1998 ◽  
Vol 114 ◽  
pp. A1302
Author(s):  
JF Miquel ◽  
C Covarrubias ◽  
AV Greco ◽  
L Puglielli ◽  
P Carvallo ◽  
...  
Keyword(s):  
Risk Factor ◽  
Cholesterol Gallstone ◽  
Gallstone Disease

scholarly journals Nucleation time: A key factor in the pathogenesis of cholesterol gallstone disease

1979 ◽  
Vol 77 (4) ◽  
pp. 611-617 ◽  
Author(s):  
Keith R. Holan ◽  
R.Thomas Holzbach ◽  
Robert E. Hermann ◽  
Avram M. Cooperman ◽  
William J. Claffey
Keyword(s):  
Cholesterol Gallstone ◽  
Gallstone Disease ◽  
Nucleation Time ◽  
Key Factor
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