Functional Impact of Breast Cancer by Age at Diagnosis

2004 ◽  
Vol 22 (10) ◽  
pp. 1849-1856 ◽  
Author(s):  
Candyce H. Kroenke ◽  
Bernard Rosner ◽  
Wendy Y. Chen ◽  
Ichiro Kawachi ◽  
Graham A. Colditz ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Elderly Women ◽  
Short Form ◽  
Life Stage ◽  
Bodily Pain ◽  
Age At Diagnosis ◽  
Health Study ◽  
Middle Aged ◽  
Elderly Age ◽  
Age Related

Purpose To explore changes in physical and psychosocial function before and after breast cancer by age at diagnosis. Patients and Methods A total of 122,969 women from the Nurses' Health Study (NHS) and NHS 2, ages 29 to 71 years, who responded to pre- and postfunctional status assessments were included; 1,082 women were diagnosed with breast cancer between 1992 and 1997. Functional status was measured using the Medical Outcomes Study Short Form 36 (SF-36). Mean change in health-related quality of life (HRQoL) scores was computed across categories representing the combination of incident breast cancer (yes or no) and age at diagnosis (≤ 40, 41 to 64, or 65+ years). Results Compared with women ≤ 40 years without breast cancer, women with breast cancer experienced significant functional declines. Young (age ≤ 40) women who developed breast cancer experienced the largest relative declines in HRQoL (as compared with middle-aged and elderly women) in multiple domains including physical roles (−18.8 v −11.5 and −7.5 points, respectively), bodily pain (−9.0 v −2.7 and −2.7 points), social functioning (−11.3 v −4.3 and −4.4 points) and mental health (−3.1 v 0.0 and +0.4 points). Much of the decline in HRQoL among elderly (age ≥ 65) women with breast cancer was age related. Conclusion Young women may fare worse than middle-aged or elderly women in both physical and psychosocial dimensions after breast cancer diagnosis. The needs of women facing breast cancer may be better understood within a life stage framework.

Cumulative Lead Exposure and Age-Related Cataract in Middle-Aged and Elderly Women

2013 ◽  
Vol 2013 (1) ◽  
pp. 5335
Author(s):  
Sung Kyun Park ◽  
Debra Schaumberg ◽  
Marc G Weisskopf ◽  
Howard Hu ◽  
Susan A. Korrick
Keyword(s):  
Lead Exposure ◽  
Elderly Women ◽  
Middle Aged ◽  
Age Related

Breast cancer in the elderly.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e11506-e11506
Author(s):  
Dilek Erdem ◽  
Bahiddin Yilmaz ◽  
Fatih Mehmet Cilingir ◽  
Selim Kocasarac ◽  
Fatih Teker ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Metastatic Disease ◽  
Elderly Women ◽  
Ductal Carcinoma ◽  
Disease Status ◽  
The Elderly ◽  
Breast Cancer Patients ◽  
Abdominal Ultrasonography ◽  
Age Related ◽  
Patient Decision

e11506 Background: Breast cancer is one of the age-related tumors that accompany with population ageing and approximately 50 % of this disease occur in 65 years of age or older and also more than 30 % occur after age of 70. This study aims to examine characteristics of patients with breast cancer 65 years or older. Methods: The study was carried out on a series of 177 breast cancer patient followed up at our outpatient clinic who are 65 years or older chosen among 848 breast cancer patients during the period 1995-2012. Physical examination, annual chest x-ray, mammography, abdominal ultrasonography and bone scan were the tools to assess the disease status. SPSS 16 was used. Results: The mean age was 70.8 years old (range 65-85 years). There was only one patient whose age is older than 85 years. 85 % of histopathology was infiltratif ductal carcinoma. 83 % of patients underwent mastectomy while 92 % was performed axillary dissection. 56 % had node positivity and 54 % had 2 cm or bigger tumor. ER/PR status was both negative in 54 women (30 %) and both positive in 82 of them. Also cerbB2 was negative in most of the patients (70 %). At the diagnosis, 20 patients (11.3 %) had metastatic disease and 157 were without metastases. Totally 44 patients (32 %) had metastatic disease and most of them (29 patients) had bone disease. Only 52 did not have endocrine therapy with 48 % had tamoxifen as a part of hormonal therapy. Most of them received radiotherapy (54 %). DFS was within 7-182 months with a median of 54 months. PFS was between 2-60 months and patients had a median OS about 61 months. 30 patients died because several causes owing to ageing causes. Conclusions: Breast cancer is the most significant cancer of women and the screening modalities with adjuvant postoperative therapies have increased survival. Acute and chronic medical conditions, nutritional status, poly-pharmacy, level of activity, disease-spesific symptoms and patient decision all need to be taken into consideration. Both in early and advanced stages of the disease, quality of life and related aspects have critical importance in elderly women who have more limited life-expectancy. It is also essential that women with breast cancer 65 years and older be included in trials and that they be recommended the best therapies available.

Acute Effects of Fluoxetine Versus Placebo on Functional Health and Well-Being in Late-Life Depression

1995 ◽  
Vol 7 (S1) ◽  
pp. 125-137 ◽  
Author(s):  
John H. Heiligenstein ◽  
John E. Ware, Jr ◽  
Kathy M. Beusterien ◽  
Paul J. Roback ◽  
Carol Andrejasich ◽  
...  
Keyword(s):  
Mental Health ◽  
Short Form ◽  
Bodily Pain ◽  
Emotional Problems ◽  
Well Being ◽  
Functional Health ◽  
Late Life Depression ◽  
Elderly Age ◽  
Sf 36 ◽  
Health And Well Being

In a randomized 6-week trial comparing fluoxetine with placebo, the Medical Outcomes Study 36-Item Short-Form Health Status Survey (SF-36) scales were used to measure the effects of treatment on functional health and well-being among elderly (age ≥ 60 years) outpatients with major depression. In the fluoxetine and placebo groups, 261 and 271 patients, respectively, completed the SF-36 before treatment and at Weeks 3 and 6. Compared with national norms for individuals over age 60, study patients before treatment exhibited baseline decrements on the following SF-36 scales: mental health, role limitations due to emotional problems, social functioning, vitality, role limitations due to physical problems, and bodily pain. Analyses of SF-36 changed scores from baseline to Week 6 revealed that the fluoxetine group improved more than the placebo group across all scales. Differences in changes of scores between groups were significant (p < .05), favoring the fluoxetine group for the scales of mental health, role limitations due to emotional problems, physical functioning, and bodily pain. Improvements observed in the fluoxetine group were both clinically and socially significant.

Dietary betaine intake is associated with skeletal muscle mass change over 3 years in middle-aged adults: the Guangzhou Nutrition and Health Study

2020 ◽  
pp. 1-8
Author(s):  
Jing-An Long ◽  
Rong-Huan Zhong ◽  
Si Chen ◽  
Fan Wang ◽  
Yun Luo ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Health Study ◽  
Middle Aged ◽  
Nutrition And Health ◽  
Skeletal Mass ◽  
Age Related ◽  
Middle Aged Adults

Abstract A higher dietary intake or serum concentration of betaine has been associated with greater lean body mass in middle-aged and older adults. However, it remains unknown whether betaine intake is associated with age-related loss of skeletal muscle mass (SMM). We assessed the association between dietary betaine intake and relative changes in SMM after 3 years in middle-aged adults. A total of 1242 participants aged 41–60 years from the Guangzhou Nutrition and Health Study 2011–2013 and 2014–2017 with body composition measurements by dual-energy X-ray absorptiometry were included. A face-to-face questionnaire was used to collect general baseline information. After adjustment for potential confounders, multiple linear regression found that energy-adjusted dietary betaine intake was significantly and positively associated with relative changes (i.e. percentage loss or increase) in SMM of legs, limbs and appendicular skeletal mass index (ASMI) over 3 years of follow-up (β 0·322 (se 0·157), 0·309 (se 0·142) and 0·303 (se 0·145), respectively; P < 0·05). The ANCOVA models revealed that participants in the highest betaine tertile had significantly less loss in SMM of limbs and ASMI and more increase in SMM of legs over 3 years of follow-up, compared with those in the bottom betaine tertile (all Ptrend < 0·05). In conclusion, our findings suggest that elevated higher dietary betaine intake may be associated with less loss of SMM of legs, limbs and ASMI in middle-aged adults.

scholarly journals Evaluating of Life Quality in Patients with Acne Vulgaris Using Generic and Specific Questionnaires

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Reza Ghaderi ◽  
Alireza Saadatjoo ◽  
Faezeh Ghaderi
Keyword(s):  
Quality Of Life ◽  
Short Form ◽  
Acne Vulgaris ◽  
Bodily Pain ◽  
Life Quality ◽  
Age Related ◽  
Gender And Age ◽  
Common Skin ◽  
The Difference

Background. Acne vulgaris is a common skin disease that can adversely affect the quality of life of patients.Objective. The aim of this study was to determine the quality of life in patients with acne vulgaris.Methods. This study was carried out on 70 patients with acne vulgaris (28 males, 42 females). All the patients filled out two Persian versions of questionnaires: short form 36 (SF-36) and Dermatology Life Quality Index (DLQI). The obtained data were analyzed by using SPSS software (version 17).Results. The scores for physical functioning, social functioning, and bodily pain domains in patients were over 70%, but the scores for role physical, general health, vitality, role emotional, and mental health in patients were under 70%. Scores on the DLQI in patients with acne vulgaris ranged from 0 to 22 (mean ± SD, 8.18 ± 4.83). After comparing mean score of DLQI with respect to gender and age, it was found that the difference between the two groups was not statistically significant.Conclusion. Acne vulgaris has a significant effect on the quality of life. There was not any significant gender or age related difference in QOL.

Utilization of preoperative breast MRI among women with newly diagnosed breast cancer.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. 1546-1546
Author(s):  
I-Wen Pan ◽  
Tina W.F. Yen ◽  
Isabelle Bedrosian ◽  
Ya-Chen T. Shih
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Distant Metastasis ◽  
Elderly Women ◽  
Breast Mri ◽  
National Study ◽  
P Value ◽  
Newly Diagnosed ◽  
Elderly Age ◽  
Factors Associated

1546 Background: The use of preoperative (pre-op) breast MRI remains controversial. Current practice may rely on patient characteristics and providers’ clinical judgment. This national study examined factors associated with pre-op breast MRI among women with newly diagnosed breast cancer (BC) and explored sources of variations. Methods: We applied the Nattinger algorithm to identify women with incident BC diagnosed between Mar 2008 and Dec 2018 from OPTUM Clinformatics database. Patients who had 26 months of full enrollment, 14 months before and 12 months after the first (index) BC surgery, and no pre-op radiotherapy were included. We defined pre-op MRI as patients who had an MRI between the date of BC diagnosis and date of index surgery. We conducted multivariable logistic regression models to examine factors associated with pre-op MRI and performed separate analyses for elderly (age > = 65) and non-elderly (age < 65) women. Results: 61,865 women (non-elderly: 27,309, elderly: 34,556) were included in the analysis. The crude rate of pre-op MRI increased from 7.4% in 2008 to 14.6% in 2018 (p-value <.001). For the non-elderly, women who were older (adjusted rates: 60-64, 10% vs 20-49, 12.1%), had no distant metastasis (10.6% vs. 12.3% with metastasis), no neoadjuvant chemotherapy (9.9% vs 15.0% with neoadjuvant), and 2 or more comorbidities (9.0% vs. 11.1% with zero comorbidity) were less likely to undergo pre-op MRI (all p-value <.001). Compared to white women (adjusted rate 10.6%), African Americans were more likely to have pre-op MRI (12.7%, p <.001) and Hispanics were less likely (8.14%, P <.001). There was no association between Health Management Organization (HMO) status and receipt of pre-op MRI among non-elderly. For elderly women, older age, more comorbidities, no distant metastasis, and no neoadjuvant chemotherapy were similarly associated with less pre-op MRI use. There was no significant association between race and receipt of pre-op MRI. Moreover, elderly women with HMO insurance were less likely to receive pre-op MRI. In both age groups, we observed wide geographic variations, with significant interaction between census division and HMO enrollment among elderly group only (Table). Conclusions: The use of pre-op MRI nearly doubled from 2008 and 2018. In addition to demographic and clinical characteristics, regional practice pattern variations and insurance type played a key role in the receipt of pre-op MRI among newly diagnosed breast cancer patients. Future study to understand this phenomenon is warranted.[Table: see text]

scholarly journals Duration and life-stage of antibiotic use and risk of cardiovascular events in women

2019 ◽  
Vol 40 (47) ◽  
pp. 3838-3845 ◽  
Author(s):  
Yoriko Heianza ◽  
Yan Zheng ◽  
Wenjie Ma ◽  
Eric B Rimm ◽  
Christine M Albert ◽  
...  
Keyword(s):  
Elderly Women ◽  
Life Stage ◽  
Composite Endpoint ◽  
Disease Status ◽  
Antibiotic Use ◽  
Health Study ◽  
Antibiotic Exposure ◽  
Older Adulthood ◽  
Hazard Ratios ◽  
Increased Risk

Abstract Aims Growing data suggest that antibiotic exposure is associated with a long-lasting alteration in gut microbiota, and may be related to subsequent cardiovascular disease (CVD). We investigated associations of life-stage and duration of antibiotic exposure during adulthood with subsequent CVD events. Methods and results This study included 36 429 women initially free of CVD and cancer from the Nurses’ Health Study. We estimated hazard ratios (HRs) for CVD (a composite endpoint of coronary heart disease or stroke) according to duration of antibiotic use in young (age 20–39), middle (age 40–59), and late (age 60 and older) adulthood. During an average of 7.6 years of follow-up, 1056 participants developed CVD. Women with long-term use of antibiotics (for ≥2 months) in late adulthood had a significantly increased risk of CVD (HR 1.32, 95% confidence interval 1.03–1.70) after adjustment for covariates (such as demographic factors, diet and lifestyle, reasons for antibiotic use, overweight or obesity, disease status, and other medication use), as compared to women who did not use antibiotics in this life-stage. Longer duration of antibiotic use in middle adulthood was also related to higher risk of CVD (P trend = 0.003) after controlling for these covariates. There was no significant relationship between the use in young adulthood and the risk of CVD. Conclusion In this study which examined the antibiotic use in different life-stages, longer duration of exposure to antibiotics in the middle and older adulthood was related to an increased risk of future CVD events among elderly women at usual risk.

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