The prognostic role of CpG island methylator phenotype in metastatic colorectal cancer.

2018 ◽  
Vol 36 (4_suppl) ◽  
pp. 667-667
Author(s):  
Kuo-Hsing Chen ◽  
Liang-In Lin ◽  
Li-Hui Tseng ◽  
Yu-Lin Lin ◽  
Jau-Yu Liau ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cpg Island ◽  
Rank Test ◽  
Prognostic Role ◽  
Cpg Island Methylator Phenotype ◽  
Poor Prognostic Factor ◽  
Significant Difference ◽  
Methylator Phenotype

667 Background: The prognostic role of CpG Island Methylator Phenotype (CIMP) in colorectal cancer (CRC) is still controversial, especially in metastatic CRC. Methods: We retrospectively analyzed the CpG island methylator phenotype (CIMP) in stage I to IV CRC specimens, which were diagnosed during 2005-2013. CIMP status was determined using a 5- gene MethyLight-based assay ( p16, MINT1, MINT2, MINT31, and MLH1). Tumors were designated as CIMP if 3 or more of 5 genes gave percent of methylated reference value ≧ 10. The clinicopatholoical characteristics, anti-cancer therapies, and the overall survival outcome were reviewed. Overall survival (OS) was compared between patients with CIMP CRC and those with non-CIMP CRC. Results: Among 450 patients with successfully determined CIMP status, 259 (57.56%) were male, 312 (70.31%) were stages I-III, 316 (70.69%) were left-sided CRC. In the survival analyses in stages I-IV patients, there was no significant difference in OS between those with or without CIMP (long rank test, p = 0.4526). Importantly, patients with metastatic CIMP CRC had poor OS than those with metastatic non-CIMP CRC (median survival, CIMP vs. non-CIMP: 1.36 vs. 3.11 years, log rank test, p = 0.0047). In a multivariate analysis, which adjusted prognostic variables such as: KRAS and BRAF mutations, microsatellite instability status, age, sex, grade, primary site, metastatic site number, chemotherapies and targeted therapies, CIMP remained an independent poor prognostic factor for OS (HR = 6.213, 95% confidence interval: 2.443 to 15.799, p = 0.0001) in metastatic CRC. In an exploratory analysis, there were more tumors with liver metastases at diagnosis in CIMP CRC than in non-CIMP CRC (94.4% vs. 71.3%, p = 0.0416). Conclusions: Our data demonstrated CIMP might independently predict poor survival in metastatic CRC in a large East Asian cohort.

scholarly journals The Role of the CpG Island Methylator Phenotype in Colorectal Cancer Prognosis Depends on Microsatellite Instability Screening Status

2010 ◽  
Vol 16 (6) ◽  
pp. 1845-1855 ◽  
Author(s):  
Anna M. Dahlin ◽  
Richard Palmqvist ◽  
Maria L. Henriksson ◽  
Maria Jacobsson ◽  
Vincy Eklöf ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Cpg Island ◽  
Cancer Prognosis ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype

CpG Island Methylator Phenotype May Predict Poor Overall Survival of Patients with Stage IV Colorectal Cancer

Oncology ◽  
2018 ◽  
Vol 96 (3) ◽  
pp. 156-163
Author(s):  
Kuo-Hsing  Chen ◽  
Liang-In  Lin ◽  
Li-Hui  Tseng ◽  
Yu-Lin Lin ◽  
Jau-Yu Liau ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Cpg Island ◽  
Stage Iv ◽  
Cpg Island Methylator Phenotype ◽  
Poor Overall Survival ◽  
Stage Iv Colorectal Cancer ◽  
Methylator Phenotype

scholarly journals The prognostic role of c-MYC amplification in schistosomiasis-associated colorectal cancer

2020 ◽  
Vol 50 (4) ◽  
pp. 446-455 ◽  
Author(s):  
Weiyu Pan ◽  
Weixia Wang ◽  
Jie Huang ◽  
Kui Lu ◽  
Sinian Huang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Positive Lymph Node ◽  
Prognostic Role ◽  
Full Cohort ◽  
Poor Prognostic Factor ◽  
Node Metastasis ◽  
Significant Difference

Abstract Objective The purpose of this study was to explore the prognostic role of c-MYC amplification in colorectal cancer, particularly in schistosomiasis-associated colorectal cancer. Methods Three hundred and fifty four cases of colorectal cancer, which were from Qingpu Branch of Zhongshan Hospital affiliated to Fudan University, were retrospectively analyzed in a tissue microarray (TMA) format, with fluorescence in situ hybridization (FISH) assay and immunohistochemistry (IHC). Results c-MYC gene amplification was found in 14.1% (50 out of 354) of patients with colorectal cancer and was correlated with old age (P = 0.028), positive lymph node metastasis (P = 0.004) and advanced stage tumors (P = 0.002). The overexpression of c-MYC was closely associated with the amplification status (P = 0.023). Kaplan–Meier survival curves for overall survival (OS) showed a statistically significant difference for patients with c-MYC amplification in full cohort of colorectal cancer, stage III-IV set and patients with lymph node metastasis (P = 0.002, 0.034, 0.012, respectively). Further analysis found c-MYC amplification associated with poorer survival in the subgroup of colorectal cancer with schistosomiasis (CRC-S, P < 0.001), but not in colorectal cancer without schistosomiasis (CRC-NS, P = 0.155). By multivariate analysis, c-MYC amplification was an independent poor-prognostic factor in CRC-S set (P = 0.046). Conclusions Our study firstly found c-MYC amplification could predict poor prognosis in schistosomiasis-associated colorectal cancer, but not in colorectal cancer without schistosomiasis.

scholarly journals CpG Island Methylator Phenotype and Prognosis of Colorectal Cancer in Northeast China

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Xia Li ◽  
Fulan Hu ◽  
Yibaina Wang ◽  
Xiaoping Yao ◽  
Zuoming Zhang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Overall Survival ◽  
Promoter Methylation ◽  
Northeast China ◽  
Proportional Hazards ◽  
Cpg Island ◽  
Sporadic Colorectal Cancer ◽  
Cpg Island Methylator Phenotype ◽  
Methylator Phenotype ◽  
Worse Prognosis

Purpose. To investigate the association between CpG island methylator phenotype (CIMP) and the overall survival of sporadic colorectal cancer (CRC) in Northeast China.Methods. 282 sporadic CRC patients were recruited in this study. We selectedMLH1,MGMT,p16,APC,MINT1,MINT31, andRUNX3as the CIMP panel markers. The promoter methylation was assessed by methylation sensitive high resolution melting (MS-HRM). Proportional hazards-regression models were fitted with computing hazard ratios (HR) and the corresponding 95% confidence intervals (95% CI).Results. 12.77% (36/282) of patients were CIMP-0, 74.1% (209/282) of patients were CIMP-L, and 13.12% (37/282) of patients were CIMP-H. The five-year survival of the 282 CRC patients was 58%. There was significant association betweenAPCgene promoter methylation and CRC overall survival (HR = 1.61; 95% CI: 1.05–2.46;P=0.03). CIMP-H was significantly associated with worse prognosis compared to CIMP-0 (HR = 3.06; 95% CI: 1.19–7.89;P=0.02) and CIMP-L (HR = 1.97; 95% CI: 1.11–3.48;P=0.02), respectively. While comparing with the combine of CIMP-L and CIMP-0 (CIMP-L/0), CIMP-H also presented a worse prognosis (HR = 2.31; 95% CI: 1.02–5.24;P=0.04).Conclusion. CIMP-H may be a predictor of a poor prognosis of CRC in Northeast China patients.

scholarly journals Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

2018 ◽  
Author(s):  
Tatiana Cajuso ◽  
Päivi Sulo ◽  
Tomas Tanskanen ◽  
Riku Katainen ◽  
Aurora Taira ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Allelic Imbalance ◽  
Cpg Island ◽  
Colorectal Carcinogenesis ◽  
Cancer Genes ◽  
Cpg Island Methylator Phenotype ◽  
Whole Genomes ◽  
Methylator Phenotype ◽  
Retrotransposon Activity

Genomic instability pathways in colorectal cancer (CRC) have been extensively studied, but the role of retrotransposition in colorectal carcinogenesis remains poorly understood. Although retrotransposons are usually repressed, they become active in several human cancers, in particular those of the gastrointestinal tract. Here we characterize retrotransposon insertions in 202 colorectal tumor whole genomes and investigate their associations with molecular and clinical characteristics. We found highly variable retrotransposon activity among tumors and identified recurrent insertions in 15 known cancer genes. In approximately 1% of the cases we identified insertions in APC, likely to be tumor-initiating events. Insertions were positively associated with the CpG island methylator phenotype and the genomic fraction of allelic imbalance. Clinically, high number of insertions was independently associated with poor disease-specific survival.

scholarly journals CpG Island Methylator Phenotype-Low (CIMP-Low) in Colorectal Cancer: Possible Associations with Male Sex and KRAS Mutations

2006 ◽  
Vol 8 (5) ◽  
pp. 582-588 ◽  
Author(s):  
Shuji Ogino ◽  
Takako Kawasaki ◽  
Gregory J. Kirkner ◽  
Massimo Loda ◽  
Charles S. Fuchs
Keyword(s):  
Colorectal Cancer ◽  
Cpg Island ◽  
Cpg Island Methylator Phenotype ◽  
Kras Mutations ◽  
Male Sex ◽  
Methylator Phenotype
Sign in / Sign up

Export Citation Format

Share Document