Association of stromal lymphocyte infiltration with tumor invasion depth and high-grade T1 bladder cancer.

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 488-488 ◽  
Author(s):  
Mathieu Rouanne ◽  
Reem Betari ◽  
Camélia Radulescu ◽  
Nicolas Signolle ◽  
Yves Allory ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Invasion ◽  
Mononuclear Cells ◽  
Cox Model ◽  
Tumor Infiltrating Lymphocytes ◽  
High Grade ◽  
Invasion Depth ◽  
Bcg Therapy ◽  
Variant Histology ◽  
Tumor Invasion Depth

488 Background: Morphological assessment of tumor-infiltrating lymphocytes (TIL) has been shown to provide prognostic and potentially predictive significance in many different tumor types. Large studies investigating TIL in urothelial carcinoma are lacking. We investigated in a homogenous population of patients with high-grade T1 (HGT1) bladder cancer the association of TIL with clinico-pathological parameters and clinical outcomes. Methods: Pretreatment index tumors were collected between 2000 and 2015 from 147 patients with primary high-grade cT1N0M0 bladder cancer. The density of stromal TIL was evaluated using hematoxylin and eosin (H&E)-based staining on whole tissue sections. Stromal TIL density was scored as percentage of stromal area infiltrated by mononuclear cells. Inter-reader assessment and stromal TIL correlation with a subset of CD3+ stained sections were evaluated. The main endpoint was correlation with overall survival (OS). Hazard ratios (HRs) and 95% CIs associated with stromal TIL were estimated through a multivariable Cox model. Results: Median follow-up was 8.2 years (6.1-9.5). Induction BCG therapy was followed by 126 patients (86%). Recurrence and progression were respectively observed in 67 patients (46%) and 40 patients (27%). Stromal TIL density was high (≥10%) in 82 tumors (56%). The overall agreement was good between the two readers (κ = 0.75). Correlation between stromal TIL density analyzed on H&E-sections and CD3+ IHC staining was high (ρ = 0.71, p < 1.10-5). Stromal TIL were positively associated with variant histology (p = 0.01) and tumor invasion depth (p = 0.03). For the OS analysis, intense (≥10%) vs. non-intense ( < 10%) stromal TIL unadjusted HR (95% CI, p) was 1.30 (0.75-2.24, p = 0.34) and adjusted HR was 1.25 (0.72-2.16, p = 0.43). Conclusions: Density of stromal TIL was associated with tumor invasion depth and variant histology, but not with prognosis of patients with HGT1 bladder cancer. These data suggest that tumor progression is associated with an increased adaptive immune response but other factors may influence outcome of patients. Characterization of TIL subpopulations may be required to identify immune-related prognostic factors.

Stromal lymphocyte infiltration is associated with tumor invasion depth but is not prognostic in high-grade T1 bladder cancer

2018 ◽  
Vol 17 (2) ◽  
pp. e1604
Author(s):  
R. Betari ◽  
M. Rouanne ◽  
C. Radulescu ◽  
N. Signolle ◽  
Y. Allory ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Tumor Invasion ◽  
High Grade ◽  
Lymphocyte Infiltration ◽  
Invasion Depth ◽  
Tumor Invasion Depth

scholarly journals Aquaporin 3 Expression Loss in Urothelial Carcinoma: Association with Tumor Invasion Depth, but not with Grading?

2017 ◽  
Vol 3 (1) ◽  
pp. 31-34 ◽  
Author(s):  
Johannes Breyer ◽  
Wolfgang Otto ◽  
Maximilian Burger ◽  
Arndt Hartmann ◽  
Peter C. Rubenwolf
Keyword(s):  
Urothelial Carcinoma ◽  
Tumor Invasion ◽  
Invasion Depth ◽  
Aquaporin 3 ◽  
Tumor Invasion Depth ◽  
Expression Loss

scholarly journals The Prognostic Value of Lymph Nodes Dissection Number on Survival of Patients with Lymph Node-Negative Gastric Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Wu Song ◽  
Yujie Yuan ◽  
Liang Wang ◽  
Weiling He ◽  
Xinhua Zhang ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Tumor Invasion ◽  
Prognostic Value ◽  
Operation Time ◽  
Invasion Depth ◽  
Node Negative ◽  
Tumor Invasion Depth

Objective.The study was designed to explore the prognostic value of examined lymph node (LN) number on survival of gastric cancer patients without LN metastasis.Methods.Between August 1995 and January 2011, 300 patients who underwent gastrectomy with D2 lymphadenectomy for LN-negative gastric cancer were reviewed. Patients were assigned to various groups according to LN dissection number or tumor invasion depth. Some clinical outcomes, such as overall survival, operation time, length of stay, and postoperative complications, were compared among all groups.Results.The overall survival time of LN-negative GC patients was50.2±30.5months. Multivariate analysis indicated that LN dissection number(P<0.001)and tumor invasion depth(P<0.001)were independent prognostic factors of survival. The number of examined LNs was positively correlated with survival time(P<0.05)in patients with same tumor invasion depth but not correlated with T1 stage or examined LNs>30. Besides, it was not correlated with operation time, transfusion volume, length of postoperative stay, or postoperative complication incidence(P>0.05).Conclusions.The number of examined lymph nodes is an independent prognostic factor of survival for patients with lymph node-negative gastric cancer. Sufficient dissection of lymph nodes is recommended during surgery for such population.

scholarly journals The Significance of Long Noncoding RNA H19 in Predicting Progression and Metastasis of Cancers: A Meta-Analysis

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Wei Jing ◽  
Man Zhu ◽  
Xian-wei Zhang ◽  
Zhong-ya Pan ◽  
Shan-shan Gao ◽  
...  
Keyword(s):  
Tumor Invasion ◽  
Noncoding Rna ◽  
Histological Grade ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Invasion Depth ◽  
Potential Marker ◽  
The Cochrane Library ◽  
The Relationship ◽  
Tumor Invasion Depth

Recently, numerous studies indicate that H19 plays a key role in tumorigenesis, but the results have been disputed, especially in the aspects of tumor progression and metastasis. Therefore, we performed this meta-analysis to systematically summarize the relationship between H19 and cancers. We searched PubMed, the Cochrane Library, CNKI, and Chinese Wan Fang to identify eligible studies. Odds ratios and 95% confidence intervals were calculated to assess the effect size. A total of 13 studies were enrolled in this meta-analysis, which was performed by Revman5.3 and Stata11.0 software. Our meta-analysis showed that the expression of H19 was associated with distant metastasis in nongastrointestinal tumors (OR = 3.85, 95% CI = 1.31–11.36,P=0.01) and, in gastrointestinal tumors (OR = 0.34, 95% CI = 0.15–0.78,P=0.01), lymph node metastasis (OR = 2.04, 95% CI = 1.19–3.48,P=0.009). Moreover, in gastric cancer, H19 expression was significantly related to histological grade (OR = 0.50, 95% CI = 0.29–0.86,P=0.01), TNM stage (OR = 0.19, 95% CI = 0.11–0.33,P<0.01), and tumor invasion depth (OR = 0.11, 95% CI = 0.04–0.27,P<0.01). Therefore, H19 could serve as a potential marker for progression and metastasis evaluation of cancers.

Clinicopathological Features of Remnant Gastric Cancer After Gastrectomy

2021 ◽  
pp. 000313482110562
Author(s):  
Kenichi Iwasaki ◽  
Edward Barroga ◽  
Yota Shimoda ◽  
Masaya Enomoto ◽  
Erika Yamada ◽  
...  
Keyword(s):  
Medical Records ◽  
Tumor Invasion ◽  
Cox Regression ◽  
Remnant Stomach ◽  
Invasion Depth ◽  
Term Outcome ◽  
Long Term Outcome ◽  
Cox Regression Analysis ◽  
Tumor Invasion Depth

Background Remnant gastric cancer (RGC) encompasses all cancers arising from the remnant stomach. Various studies have reported on RGC and its prognosis, but no consensus on its surgical treatment and postoperative management has been reached. Moreover, the correlation between the clinicopathological characteristics and long-term outcomes of RGC remains unclear. This study investigated the clinicopathological factors associated with the long-term survival of RGC patients. Methods The medical records (March 1993-September 2020) of 104 RGC patients from Tokyo Medical University Hospital database were analyzed. Of these 104 patients, the medical records of 63 patients who underwent surgical curative resection were analyzed using R. Kaplan-Meier plots of cumulative incidence of RGC were made. Differences in survival rates were compared using the log-rank test. Prognostic factors were analyzed using multivariate Cox regression analysis ( P < .05). Results Of the 104 RGC patients, 63 underwent total remnant stomach excision. The median time from the first surgery to the total excision was 10 years. The 5-year survival rate of the 63 RGC patients was .55 ((95% CI); .417-.671). The clinicopathological factors that were significantly associated with the long-term outcome of the RGC patients were tumor diameter (≥3.5 cm), presence or absence of combined resection of multiple organs, tumor invasion (deeper than T2), TNM stage, and postoperative morbidity. The multivariate Cox regression analysis showed that tumor invasion depth was the only independent prognostic factor for RGC patients [HR (95% CI): 5.49 (2.629-11.5), P ≤ .005]. Conclusions Among prognostic factors, tumor invasion depth was the only independent factor affecting RGC’s long-term outcome.

Endoscopic prediction of tumor invasion depth in early gastric cancer

2011 ◽  
Vol 73 (5) ◽  
pp. 917-927 ◽  
Author(s):  
Jeongmin Choi ◽  
Sang Gyun Kim ◽  
Jong Pil Im ◽  
Joo Sung Kim ◽  
Hyun Chae Jung ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Tumor Invasion ◽  
Invasion Depth ◽  
Tumor Invasion Depth

The DEAL trial: A diet and exercise intervention in (pre)-diabetics during treatment for non-muscle invasive bladder cancer.

2018 ◽  
Vol 36 (6_suppl) ◽  
pp. 473-473
Author(s):  
Woodson Smelser ◽  
Vassili Glazyrine ◽  
Brian Barnes ◽  
Abigail Stanley ◽  
Misty Bechtel ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Dietary Intervention ◽  
Exercise Intervention ◽  
Invasive Bladder Cancer ◽  
Laboratory Evaluation ◽  
Diabetic Patients ◽  
High Grade ◽  
Muscle Invasive Bladder Cancer ◽  
Bcg Therapy ◽  
Muscle Invasive

473 Background: Patients with diabetes are at greater risk for bladder cancer (BC) as well as disease recurrence and progression. Even after controlling for clinical and pathologic risk factors, DM confers a 2x greater risk of recurrence and 9x greater risk of progression. We hypothesize that utilizing a carbohydrate restricted (CR) diet ( < 130 grams/day) to decrease the bioavailability of glucose in patients with DM and BC, a “Warburg-like” tumor, has potential therapeutic benefit. We designed a study to assess the feasibility of a CR diet in patients with (pre)diabetes and non-muscle invasive bladder cancer receiving BCG therapy. Methods: This is a pilot study of 5 (pre)diabetic patients (defined as HgbA1c > 5.7) with NMIBC receiving BCG and maintenance. A CR diet ( < 130 g/day) was supplied for the first 12 weeks through a meal delivery service. Patients received weekly coaching with a nutritionist for 6 weeks during induction BCG and at the 3 month surveillance cystoscopy with dietary and activity goals implemented. Patients had laboratory evaluation at baseline and at 3 month intervals. Patients tracked their diet. Two (1 weekday, 1 weekend day) unannounced 24 hour diet recalls were obtained to monitor compliance. Dietary compliance was defined as < 130 grams/day of carbohydrate intake. Results: Between 09/2016 and 05/2017, 5 patients were enrolled. Mean age was 66.2 years (Range 59-74). Three patients had diabetes and two patients had pre-diabetes. Two patients had CIS, 1 patient had high-grade Ta, and 2 patients had high-grade T1 disease. Mean baseline hemoglobin A1c was 7.6% (Range 5.9-11.8). Mean bodyweight and BMI were 92 kg (Range 66-105) and 28.2 (Range 23.1- 31.3) respectively. Regarding compliance, 4/5 (80%) patients completed dietary logs and weekly labs. Three patients (60%) achieved their goal of < 130 grams carbohydrates/day on 24-hour dietary recall. Average 3-month HbA1c improved from 7.6% to 6.6% (Range 5.6-7.9). Conclusions: Eighty percent of patients completed dietary logs for the first three months of the trial; 60% achieved compliance with the CR diet. These data demonstrate the feasibility of a dietary intervention utilizing CR in patients with high-grade NMIBC undergoing BCG. Clinical trial information: NCT02716623.

1004 Impact of BCG therapy in high-grade T1 bladder cancer: A meta-analysis based on 2,687 patients

2014 ◽  
Vol 13 (1) ◽  
pp. e1004-e1004a
Author(s):  
J.J. Leow ◽  
W. Martin-Doyle ◽  
A. Orsola ◽  
S.L. Chang ◽  
J. Bellmunt
Keyword(s):  
Bladder Cancer ◽  
Meta Analysis ◽  
High Grade ◽  
Bcg Therapy

scholarly journals Assessment of Tumor Invasion Depth in Colorectal Carcinoma Using Multiphoton Microscopy

2015 ◽  
Vol 7 (2) ◽  
pp. 1-8 ◽  
Author(s):  
Shu Wang ◽  
Jianxin Chen ◽  
Yinghong Yang ◽  
Weizhong Jiang ◽  
Changyin Feng ◽  
...  
Keyword(s):  
Colorectal Carcinoma ◽  
Tumor Invasion ◽  
Multiphoton Microscopy ◽  
Invasion Depth ◽  
Tumor Invasion Depth

scholarly journals Stromal lymphocyte infiltration is associated with tumour invasion depth but is not prognostic in high-grade T1 bladder cancer

2019 ◽  
Vol 108 ◽  
pp. 111-119 ◽  
Author(s):  
Mathieu Rouanne ◽  
Reem Betari ◽  
Camélia Radulescu ◽  
Aïcha Goubar ◽  
Nicolas Signolle ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
High Grade ◽  
Lymphocyte Infiltration ◽  
Tumour Invasion ◽  
Invasion Depth
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