scholarly journals Concurrent chromatographic determination of pseudoephedrine and loratadine from combination syrups and tablets

2021 ◽  
Vol 7 (1) ◽  
Author(s):  
Imad Osman Abu Reid
Keyword(s):  
Ammonium Acetate ◽  
Chemical Properties ◽  
Chromatographic Determination ◽  
Analytical Challenge ◽  
Intermediate Precision ◽  
Box Behnken Design ◽  
Complex Samples ◽  
System Suitability ◽  
Nonpolar Compounds

Abstract Background Chromatographic separation of polar and nonpolar compounds when presented in combined dosage forms has always been considered as great analytical challenge. Separation and retention of both polar and nonpolar compounds by the same stationary phase can be a useful approach for analyses of complex samples with such a difference in chemical properties. Loratadine (nonpolar) and pseudoephedrine (polar) are typical examples of this situation. Results The Box–Behnken design was used to optimize the separation process, an efficient separation of loratadine and pseudoephedrine was achieved within 6 min; employing a mixture of 16.0 mM ammonium acetate buffer (pH 4.5) and acetonitrile (23:77, v/v) as isocratic mobile phase, pumped at 1.0 mL/min through a Zorbax cyanopropyl column (250 mm × 4.6 mm, 5 μm), the analytes were detected at 250 nm. Under the same conditions, separation of sodium benzoate preservative co-formulated with the two analytes in syrup formulation was also achieved. The calibration curve demonstrated excellent linearity in the range of 24.6–123.2 μg/mL and 594.8–2974.0 μg/mL for loratadine and pseudoephedrine, respectively with determination coefficient (r2) > 0.999. Conclusion The method’s accuracy bias < 2.0%, repeatability and intermediate precision (%RSD < 2.0%) were verified. In addition, system suitability parameters were found within the acceptable limits. Satisfactory results were obtained upon the application of the validated method to the analysis of commercial tablet and syrup formulations.

Direct analysis of radium-226 in sediment by ICP-MS: an analytical challenge?

2019 ◽  
Vol 34 (8) ◽  
pp. 1597-1605 ◽  
Author(s):  
Hamza Ben Yaala ◽  
Rihab Fniter ◽  
Delphine Foucher ◽  
Olivier Clarisse
Keyword(s):  
Direct Analysis ◽  
Analytical Challenge ◽  
Natural Sediment ◽  
Icp Ms ◽  
Low Levels

Low levels of radium-226 were accurately measured in natural sediment digests using single quadrupole ICP-MS.

Selenium in Sewage Sludge; General Aspects and Analytical Challenge

1997 ◽  
Vol 67 (1-4) ◽  
pp. 1-13 ◽  
Author(s):  
I. Heninger ◽  
M. Potin-gautier ◽  
M. Astruc ◽  
D. Snidaro ◽  
V. Vignier ◽  
...  
Keyword(s):  
Sewage Sludge ◽  
Analytical Challenge ◽  
General Aspects

scholarly journals Volatile sulphur Compounds in Cheeses – An Odorous Analytical Challenge

2013 ◽  
Vol 67 (7) ◽  
pp. 610-610
Author(s):  
Pascal Fuchsmann ◽  
Stefan Irmler ◽  
Katharina Breme
Keyword(s):  
Analytical Challenge ◽  
Sulphur Compounds ◽  
Volatile Sulphur Compounds

The Analytical Challenge in the Determination of Cathinones, Key-Players in the Worldwide Phenomenon of Novel Psychoactive Substances

2018 ◽  
Vol 48 (5) ◽  
pp. 372-390 ◽  
Author(s):  
Rosa A. S. Couto ◽  
Luís Moreira Gonçalves ◽  
Félix Carvalho ◽  
José A. Rodrigues ◽  
Cecília M. P. Rodrigues ◽  
...  
Keyword(s):  
Novel Psychoactive Substances ◽  
Analytical Challenge ◽  
Psychoactive Substances ◽  
Key Players ◽  
Worldwide Phenomenon
Sign in / Sign up

Export Citation Format

Share Document