Bioadhesive Ophthalmic Drug Inserts (BODI)

2002 ◽  
pp. 341-347
Author(s):  
R Gurny ◽  
Olivia Felt-Baeyens
Keyword(s):  
Ophthalmic Drug

Review of ophthalmic drug delivery by contact lenses

2014 ◽  
Vol 24 (2) ◽  
pp. 123-135 ◽  
Author(s):  
K.-H. Hsu ◽  
S. Gause ◽  
A. Chauhan
Keyword(s):  
Drug Delivery ◽  
Contact Lenses ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

scholarly journals Flexible Polymeric Nanosized Micelle for Ophthalmic Drug Delivery: Research Progress in Recent Three Years

2021 ◽  
Author(s):  
Zhiguo Li ◽  
Mingting Liu ◽  
Lingjie Ke ◽  
Li-Juan Wang ◽  
Caisheng Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Complex Structure ◽  
Research Progress ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Delivery Technology

The eye is a complex structure with a variety of anatomical barriers and clearance mechanisms, so the provision of safe and effective ophthalmic drug delivery technology is a major challenge....

scholarly journals Contact Lenses as Ophthalmic Drug Delivery Systems: A Review

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1102
Author(s):  
Paola Franco ◽  
Iolanda De Marco
Keyword(s):  
Contact Lenses ◽  
Pharmacological Action ◽  
Active Principle ◽  
Prolonged Release ◽  
Eye Drops ◽  
Polymeric Support ◽  
Physiological Factors ◽  
Ophthalmic Drugs ◽  
Innovative Methods ◽  
Ophthalmic Drug

Ophthalmic drugs used for the treatment of various ocular diseases are commonly administered by eye drops. However, due to anatomical and physiological factors, there is a low bioavailability of the active principle. In order to increase the drug residence time on the cornea to adequate levels, therapeutic contact lenses have recently been proposed. The polymeric support that constitutes the contact lens is loaded with the drug; in this way, there is a direct and effective pharmacological action on the target organ, promoting a prolonged release of the active principle. The incorporation of ophthalmic drugs into contact lenses can be performed by different techniques; nowadays, the soaking method is mainly employed. To improve the therapeutic performance of drug-loaded contact lenses, innovative methods have recently been proposed, including the impregnation with supercritical carbon dioxide. This updated review of therapeutic contact lenses production and application provides useful information on the most effective preparation methodologies, recent achievements and future perspectives.

scholarly journals Ophthalmic Drug Delivery Systems for the Treatment of Retinal Diseases: Basic Research to Clinical Applications

2010 ◽  
Vol 51 (11) ◽  
pp. 5403 ◽  
Author(s):  
Henry F. Edelhauser ◽  
Cheryl L. Rowe-Rendleman ◽  
Michael R. Robinson ◽  
Daniel G. Dawson ◽  
Gerald J. Chader ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Basic Research ◽  
Delivery Systems ◽  
Clinical Applications ◽  
Retinal Diseases ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

scholarly journals Ophthalmic Drug Dosage Forms: Characterisation and Research Methods

2014 ◽  
Vol 2014 ◽  
pp. 1-14 ◽  
Author(s):  
Przemysław Baranowski ◽  
Bożena Karolewicz ◽  
Maciej Gajda ◽  
Janusz Pluta
Keyword(s):  
Defense Mechanisms ◽  
Drug Application ◽  
Drug Dosage ◽  
Eye Drops ◽  
Eye Tissues ◽  
Ophthalmic Drug ◽  
Application Frequency

This paper describes hitherto developed drug forms for topical ocular administration, that is, eye drops, ointments,in situgels, inserts, multicompartment drug delivery systems, and ophthalmic drug forms with bioadhesive properties. Heretofore, many studies have demonstrated that new and more complex ophthalmic drug forms exhibit advantage over traditional ones and are able to increase the bioavailability of the active substance by, among others, reducing the susceptibility of drug forms to defense mechanisms of the human eye, extending contact time of drug with the cornea, increasing the penetration through the complex anatomical structure of the eye, and providing controlled release of drugs into the eye tissues, which allows reducing the drug application frequency. The rest of the paper describes recommendedin vitroandin vivostudies to be performed for various ophthalmic drugs forms in order to assess whether the form is acceptable from the perspective of desired properties and patient’s compliance.

Nanocarriers for treatment of ocular neovascularization in the back of the eye: new vehicles for ophthalmic drug delivery

Nanomedicine ◽  
2015 ◽  
Vol 10 (13) ◽  
pp. 2093-2107 ◽  
Author(s):  
Hsin-Hui Shen ◽  
Elsa C Chan ◽  
Jia Hui Lee ◽  
Youn-Shen Bee ◽  
Tsung-Wu Lin ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Ocular Neovascularization ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

Polycarboxylic acid nanoparticles for ophthalmic drug delivery: anex vivoevaluation with human cornea

2004 ◽  
Vol 21 (8) ◽  
pp. 841-855 ◽  
Author(s):  
T. K. De ◽  
E. J. Bergey ◽  
S. J. Chung ◽  
D. J. Rodman ◽  
D. J. Bharali ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Human Cornea ◽  
Polycarboxylic Acid ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug

scholarly journals Hydrogel Contact Lens for Extended Delivery of Ophthalmic Drugs

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Xiaohong Hu ◽  
Lingyun Hao ◽  
Huaiqing Wang ◽  
Xiaoli Yang ◽  
Guojun Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Contact Lens ◽  
Contact Lenses ◽  
Drug Carriers ◽  
Soft Contact ◽  
Soft Contact Lenses ◽  
Advantages And Disadvantages ◽  
Ophthalmic Drug Delivery ◽  
Ophthalmic Drug ◽  
Polymeric Hydrogels

Soft contact lenses can improve the bioavailability and prolong the residence time of drugs and, therefore, are ideal drug carriers for ophthalmic drug delivery. Hydrogels are the leading materials of soft contact lenses because of their biocompatibility and transparent characteristic. In order to increase the amount of load drug and to control their release at the expected intervals, many strategies are developed to modify the conventional contact lens as well as the novel hydrogel contact lenses that include (i) polymeric hydrogels with controlled hydrophilic/hydrophobic copolymer ratio; (ii) hydrogels for inclusion of drugs in a colloidal structure dispersed in the contact lenses; (iii) ligand-containing hydrogels; (iv) molecularly imprinted polymeric hydrogels; (v) hydrogel with the surface containing multilayer structure for drugs loading and releasing. The advantages and disadvantages of these strategies in modifying or designing hydrogel contact lenses for extended ophthalmic drug delivery are analyzed in this paper.

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