Vanadium Toxicity Revisited

2020 ◽  
pp. 323-343
Author(s):  
Rituparna Ghosh ◽  
Ahana Das ◽  
Arnab Bandyopadhyay ◽  
Rajib Majumder ◽  
Samudra Prosad Banik
Keyword(s):  
Vanadium Toxicity

scholarly journals Neuroprotective Effect of Grewia carpinifolia Extract against Vanadium Induced Behavioural Impairment

2016 ◽  
Vol 60 (4) ◽  
pp. 5-13 ◽  
Author(s):  
O. E. Adebiyi ◽  
J. O. Olopade ◽  
F. O. Olayemi
Keyword(s):  
Neuroprotective Effect ◽  
Ethanolic Extract ◽  
Control Group ◽  
Protective Agent ◽  
Central Nervous System Toxicity ◽  
Sodium Metavanadate ◽  
Latent Time ◽  
Group A ◽  
Vanadium Toxicity ◽  
Group B

Abstract Vanadium (V), a heavy metal, has been reported to induce central nervous system toxicity leading to various behavioural impairments. It is characterized by the production of reactive oxygen. The present study was designed to test the possibility of Grewia carpinifolia ethanolic extract in preventing behavioural alterations following acute vanadium toxicity in mice. Twenty five Swiss albino mice (25—27 g) were completely randomized into 5 groups (A—E) of 5 animals each. Group A received distilled water and served as a control; group B, received vitamin E (500 mg.kg−1 b. w. every 72 hours), a known antioxidant orally, along with a daily dose of sodium metavanadate intraperitoneally (i. p.) for 7 days; group C and group D received Grewia carpinifolia leaf extract at 100 and 200 mg.kg−1 b.w orally respectively, along with the sodium metavanadate i. p. for 7 days; while group E received sodium metavanadate i. p. only for 7 days. The behavioural and motor functions were analysed by the open field, negative geotaxis, and hanging wire tests; the daily body and brain weights were recorded. Grewia carpinifolia ethanolic extracts significantly reduced the number of grooming, stretched attend posture, and freezing time that were significantly increased in the vanadium only group and also enhanced the vestibular functions. In addition, the latent time spent on the hanging wire in groups simultaneously administered with the extract and V compared favourably (P > 0.05) with the control groups but a decrease in latent time was observed in the V only group. The results suggest that acute V toxicity results in various behavioural deficits and support a possible role of Grewia carpinifolia as a protective agent against acute vanadium-toxicity with a better result at 200 mg.kg−1 b. w.

Dual Effects of Vanadium: Toxicity Analysis in Developing Therapeutic Lead-Ups

2016 ◽  
pp. 337-354 ◽  
Author(s):  
Rituparna Ghosh ◽  
Samudra Banik
Keyword(s):  
Toxicity Analysis ◽  
Vanadium Toxicity

scholarly journals Protective Effects of Dietary Antioxidants against Vanadium-Induced Toxicity: A Review

2020 ◽  
Vol 2020 ◽  
pp. 1-14 ◽  
Author(s):  
Iwona Zwolak
Keyword(s):  
Oxidative Stress ◽  
Animal Studies ◽  
Toxic Metal ◽  
Protective Effects ◽  
Dietary Antioxidants ◽  
Vanadium Toxicity ◽  
Preventive Effects

Vanadium (V) in its inorganic forms is a toxic metal and a potent environmental and occupational pollutant and has been reported to induce toxic effects in animals and people. In vivo and in vitro data show that high levels of reactive oxygen species are often implicated in vanadium deleterious effects. Since many dietary (exogenous) antioxidants are known to upregulate the intrinsic antioxidant system and ameliorate oxidative stress-related disorders, this review evaluates their effectiveness in the treatment of vanadium-induced toxicity. Collected data, mostly from animal studies, suggest that dietary antioxidants including ascorbic acid, vitamin E, polyphenols, phytosterols, and extracts from medicinal plants can bring a beneficial effect in vanadium toxicity. These findings show potential preventive effects of dietary antioxidants on vanadium-induced oxidative stress, DNA damage, neurotoxicity, testicular toxicity, and kidney damage. The relevant mechanistic insights of these events are discussed. In summary, the results of studies on the role of dietary antioxidants in vanadium toxicology appear encouraging enough to merit further investigations.

Subacute Vanadium Toxicity in Rats.

2000 ◽  
Vol 46 (6) ◽  
pp. 503-508 ◽  
Author(s):  
Atsuko Adachi ◽  
Kaoru Asai ◽  
Yukari Koyama ◽  
Yumiko Matsumoto ◽  
Toshio Okano
Keyword(s):  
Vanadium Toxicity

scholarly journals Vanadium Toxicity in Laying Hens

1963 ◽  
Vol 42 (6) ◽  
pp. 1407-1411 ◽  
Author(s):  
Lawrence R. Berg ◽  
Gordon E. Bearse ◽  
Louis H. Merrill
Keyword(s):  
Laying Hens ◽  
Vanadium Toxicity

scholarly journals Vanadium toxicity in chickpea (Cicer arietinum L.) grown in red soil: Effects on cell death, ROS and antioxidative systems

2018 ◽  
Vol 158 ◽  
pp. 139-144 ◽  
Author(s):  
Muhammad Imtiaz ◽  
Muhammad Ashraf ◽  
Muhammad Shahid Rizwan ◽  
Muhammad Amjad Nawaz ◽  
Muhammad Rizwan ◽  
...  
Keyword(s):  
Cell Death ◽  
Cicer Arietinum ◽  
Red Soil ◽  
Cicer Arietinum L ◽  
Antioxidative Systems ◽  
Soil Effects ◽  
Vanadium Toxicity
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