The Antioxidant Effects of Inositol Phosphates

SummaryEicosapentaenoic acid (EPA) inhibits platelet responsiveness to aggregating agents. To investigate the reactions that are affected by EPA, we examined the effect of preincubating aspirintreated rabbit platelets with EPA on stimulation of inositol phosphate formation in response to the TXA2 analogue U46619. Stimulation of platelets with U46619 (0.5 μM) caused aggregation and slight release of dense granule contents; aggregation and release were inhibited by preincubation of the platelets with EPA (50 μM) for 1 h followed by washing to remove unincorporated EPA. Incubation with EPA (50 μM) for 1 h did not cause a detectable increase in the amount of EPA in the platelet phospholipids. When platelets were prelabelled with [3H]inositol stimulation with U46619 of control platelets that had not been incubated with EPA significantly increased the labelling of mos1tol phosphates. The increases in inositol phosphate labelling due to U46619 at 10 and 60 s were partially inhibited by premcubat10n of the platelets with 50 μM EPA. Since the activity of cyclo-oxygenase was blocked with aspirin, inhibition of inositol phosphate labelling in response to U46619 indicates either that there may be inhibition of signal transduction without a detectable change in the amount of EPA in platelet phospholipids, that changes in signal transduction require only minute changes in the fatty acid composition of membrane phospholipids, or that after a 1 h incubation with EPA, activation of phospholipase C is affected by a mechanism that is not directly related to incorporation of EPA.

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Carum copticum L. essential oils as natural antimicrobial and antioxidant

Bangladesh Journal of Botany ◽

10.3329/bjb.v44i4.38564 ◽

2018 ◽

Vol 44 (4) ◽

pp. 515-520

Author(s):

M Kazemi

Keyword(s):

Essential Oils ◽

Radical Scavenging Activity ◽

Radical Scavenging ◽

Dpph Radical ◽

Dpph Radical Scavenging Activity ◽

Carum Copticum ◽

Microbial Strains ◽

Pharmaceutical Industries ◽

Dpph Radical Scavenging ◽

Antioxidant Effects

Carum copticum L. comprises several relevant species for food, cosmetic, perfumery and pharmaceutical industries. GC/MS analysis of the enential oil of C. copticum revealed γ- terpinene as a major component of C. copticum, with its contribution of 33.85%. Essential oils (EOs) exhibited a significant antimicrobial activity against all tested microbial strains. In addition, the C. copticum oil demonstrated the highest DPPH radical scavenging activity. These results clearly show the antimicrobial and antioxidant effects of the plant essential oil.

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Antioxidant Effects of Medicinal Mushrooms Agaricus brasiliensis and Ganoderma lucidum (Higher Basidiomycetes): Evidence from Animal Studies

International Journal of Medicinal Mushrooms ◽

10.1615/intjmedmushrooms.v17.i10.40 ◽

2015 ◽

Vol 17 (10) ◽

pp. 943-955 ◽

Cited By ~ 7

Author(s):

Borys Yurkiv ◽

Solomon P. Wasser ◽

Eviatar Nevo ◽

Nataliya O. Sybirna

Keyword(s):

Ganoderma Lucidum ◽

Animal Studies ◽

Medicinal Mushrooms ◽

Agaricus Brasiliensis ◽

Antioxidant Effects

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Defensive activity of Hesperidin against Ciprofloxacin induced hepatic injury in rabbits.

International Journal of Pharmaceutical Quality Assurance ◽

10.25258/ijpqa.10.3.29 ◽

2019 ◽

Vol 10 (03) ◽

Author(s):

Hawraa M. Murad ◽

Tamadhur Hani Hussein ◽

Audai Sulaiman Khudhair ◽

Manal Muhi Murad ◽

Jawad Kadhim Faris

Keyword(s):

Body Weight ◽

Bacterial Infections ◽

Hepatoprotective Activity ◽

The Body ◽

Local Breed ◽

Group 4 ◽

Group 3 ◽

Group 2 ◽

Defensive Activity ◽

Antioxidant Effects

This study was conducted to find out hepatoprotective activity of hesperidin (HES) 100mg/kg body weight (b.w.) against ciprofloxacin (CPX) 100 mg/kg induced hepatotoxicity in local breed rabbits .CPX is a broad spectrum antibiotic used for treatment of many bacterial infections. Twenty four male rabbits were divided into four groups ,group1: control, (1 ml/kg Saline orally) group 2: CPX (100 mg/kg orally) for (14) consecutive days , group 3: HES (100 mg//kg) orally for (14) consecutive days group 4: CPX (100 mg/kg orally) plus HES (100 mg//kg orally ) for (14) consecutive days. All the rabbits were killed on the (15) day of the experiment, and then the blood, and livers samples were taken. CPX induced hepatotoxicity was proved by a significant (p less than 0.01) reduction in the body weight ,and a significant (p less than 0.01) increased serum aspartate transaminase (AST), alanine transaminase (ALT) , Malonaldehyde enzyme (MAD) and histopathological changes. Protective hepatic toxicity effect and oxidative damage caused by CPX significantly (p less than 0.01) increasing in body weight and significantly (p less than 0.01) decreasing AST , ALT, MAD and improving tissue morphology in HES (100 mg//kg) . These results assure that HES (100 mg//kg) antioxidant effects can protect CPX-induced hepatotoxicity in rabbits.

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