Role of Intestinal Cytochromes P450 in Drug Disposition

2003 ◽  
pp. 421-451
Author(s):  
Kenneth Thummel ◽  
Mary Paine
Keyword(s):  
Drug Disposition ◽  
Cytochromes P450

Drug Interactions with Angiotensin Receptor Blockers: Role of Human Cytochromes P450

2016 ◽  
Vol 17 (7) ◽  
pp. 681-691 ◽  
Author(s):  
Ruirui Yang ◽  
Zhiqiang Luo ◽  
Yang Liu ◽  
Mohan Sun ◽  
Ling Zheng ◽  
...  
Keyword(s):  
Drug Interactions ◽  
Cytochromes P450 ◽  
Angiotensin Receptor Blockers ◽  
Angiotensin Receptor ◽  
Receptor Blockers

Enzyme-Mediated Protein Haptenation of Dapsone and Sulfamethoxazole in Human Keratinocytes: I. Expression and Role of Cytochromes P450

2006 ◽  
Vol 319 (1) ◽  
pp. 488-496 ◽  
Author(s):  
Piyush M. Vyas ◽  
Sanjoy Roychowdhury ◽  
Farah D. Khan ◽  
Thomas E. Prisinzano ◽  
Jatinder Lamba ◽  
...  
Keyword(s):  
Cytochromes P450 ◽  
Human Keratinocytes

Chapter Thirteen The role of cytochromes P450 in biosynthesis and evolution of glucosinolates

2002 ◽  
pp. 223-248 ◽  
Author(s):  
Barbara Ann Halkier ◽  
Carste Hørslev Hansen ◽  
Michae Dalgaard Mikkelsen ◽  
Peter Naur ◽  
Ute Wittstock
Keyword(s):  
Cytochromes P450

Possible role of serum protein binding to improve drug disposition

1994 ◽  
Vol 108 (3) ◽  
pp. 241-247 ◽  
Author(s):  
Yamashita Shinji ◽  
Nadai Tanekazu ◽  
Sumi Masao ◽  
Suda Yasuo
Keyword(s):  
Protein Binding ◽  
Serum Protein ◽  
Drug Disposition ◽  
Serum Protein Binding

Role of hepatic cytochromes P450 in bioactivation of the anticancer drug ellipticine: Studies with the hepatic NADPH:Cytochrome P450 reductase null mouse

2008 ◽  
Vol 226 (3) ◽  
pp. 318-327 ◽  
Author(s):  
Marie Stiborová ◽  
Volker M. Arlt ◽  
Colin J. Henderson ◽  
C. Roland Wolf ◽  
Věra Kotrbová ◽  
...  
Keyword(s):  
Anticancer Drug ◽  
Cytochromes P450 ◽  
Null Mouse ◽  
P450 Reductase ◽  
Nadph:Cytochrome P450 Reductase

scholarly journals Equine Drug Transporters: A Mini-Review and Veterinary Perspective

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1064
Author(s):  
Brielle Rosa
Keyword(s):  
Drug Transport ◽  
Drug Disposition ◽  
Drug Transporters ◽  
Transport Proteins ◽  
Pharmacokinetic Parameters ◽  
Transporter Protein ◽  
Drug Pharmacokinetic ◽  
Species Specific ◽  
And Function

Xenobiotic transport proteins play an important role in determining drug disposition and pharmacokinetics. Our understanding of the role of these important proteins in humans and pre-clinical animal species has increased substantially over the past few decades, and has had an important impact on human medicine; however, veterinary medicine has not benefitted from the same quantity of research into drug transporters in species of veterinary interest. Differences in transporter expression cause difficulties in extrapolation of drug pharmacokinetic parameters between species, and lack of knowledge of species-specific transporter distribution and function can lead to drug–drug interactions and adverse effects. Horses are one species in which little is known about drug transport and transporter protein expression. The purpose of this mini-review is to stimulate interest in equine drug transport proteins and comparative transporter physiology.

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