scholarly journals Bone Growth with Low Bone Mineral Content in Very Low Birth Weight Premature Infants

1986 ◽  
Vol 20 (10) ◽  
pp. 925-928 ◽  
Author(s):  
Frank R Greer ◽  
Ann Mccormick
1994 ◽  
Vol 83 (s405) ◽  
pp. 117-122 ◽  
Author(s):  
AA Lapillonne ◽  
FH Glorieux ◽  
BL Salle ◽  
PM Braillon ◽  
M Chambon ◽  
...  

2009 ◽  
Vol 102 (8) ◽  
pp. 1117-1120 ◽  
Author(s):  
June Kohut ◽  
Bruce Watkins ◽  
Hope Weiler

The infant born small size for gestational age (SGA) has low bone mass. Since dietary arachidonic acid (AA) and DHA enhance bone mass in normal-birth-weight piglets the objective of the present study was to test for such benefits in the SGA piglet. In the present 15 d study, two levels of dietary AA and DHA (6:1 ratio of AA:DHA diets, 0·6:0·1 or 1·2:0·2 g/100 g dietary fat) v. a control diet were tested for effects on growth, fatty acid status, whole-body and regional bone mineral content (BMC) and metabolism in SGA piglets categorised as either very low birth weight (VLBW; ≤ 1·0 kg; n 12) or low birth weight (LBW; 1·1 to 1·2 kg; n 18). Differences in outcomes for each body weight category were detected using ANOVA with post hoc Bonferroni tests. Growth was not influenced by diet, yet the LBW piglets fed 0·6:0·1 AA and DHA as g/100 g fat had elevated BMC in the spine, whereas the VLBW piglets had higher BMC of the spine if fed the higher intake of AA and DHA. In both weight categories, the higher intake of AA and DHA lowered bone resorption relative to controls, whereas bone formation was unchanged. Tissue fatty acid concentrations reflected dietary AA and DHA, especially trabecular bone of VLBW piglets. Whether the enhanced lumbar spine BMC is due to enhanced Ca absorption and thus suppression of bone resorption remains to be established.


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