scholarly journals Adenosine Concentration in Umbilical Cord Blood of Newborn Infants after Vaginal Delivery and Cesarean Section

1989 ◽  
Vol 26 (2) ◽  
pp. 106-108 ◽  
Author(s):  
Lars Irestedt ◽  
Ingrid Dahlin ◽  
Torbjörn Hertzberg ◽  
Alf Sollevi ◽  
Hugo Lagercrantz
Keyword(s):  
Cesarean Section ◽  
Cord Blood ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
Adenosine Concentration

The Effect of Anesthesia on Chemokine Production in the Cord Blood Off Neonates.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 3875-3875
Author(s):  
Barbara Krolak-Olejnik ◽  
Igor Olejnik
Keyword(s):  
Logistic Regression ◽  
Cesarean Section ◽  
Cord Blood ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Tissue Injury ◽  
Severe Depression ◽  
Chemokine Production ◽  
Cc Chemokines

Abstract Animal experiments have shown a correlation between anesthesia and surgery on one hand, and depressed immune response and infections on the other hand. Patients who are anergic or become anergic post-operatively and patients with a severe depression of T lymphocyte proliferative responses are at the risk of developing life-threatening sepsis. Activation of inflammatory mediators and the acute inflammatory response remains a local event after minor injury, whereas more severe tissue injury may provoke a systemic response. Chemokines play a major role in the course of inflammatory events. Chemokines represent a large superfamily of chemotactic cytokines that facilitate leukocyte recruitment and activation during immunological response at the site of inflammation. The majority of chemokines are members of CC or CXC family, based on relative position of their cysteine residues. CXC chemokines containing the ELR sequence, such as IL-8, GRO-α and ENA-78 attract mainly neutrophils, while CC chemokines such as RANTES, MIP-1α and MIP-1β do not act on neutrophils, but attract monocytes, eosinophils, basophils and T lymphocytes. The aim of the study was to investigate chemokine production in the umbilical cord blood of neonates with regard to mother’s anesthesia during labor. We also tried to answer the question, whether cesarean section can influence the concentrations of chemokines in the neonate. Concentrations of the chemokines were quantified in the umbilical cord blood by specific ELISA using double-antibody sandwich technique according to manufacturer’s instructions (Quantikine IL-8, GRO-α, ENA-78, RANTES, MIP-1α and MIP-1β, R&D Systems). The study group comprised 115 singleton neonates, without congenital malformations. All neonates were mature, appropriate for gestational age, the APGAR score were ≥ 8 in the first minute of life. The mothers were infection free during pregnancy and before delivery, which was performed either vaginally (n=69), or by cesarean section, urgent (n=16) or scheduled (n=30). Descriptive statistics are given by median and quartiles. Overall group comparisons were carried for each chemokine using the Mann-Whitney’s U- test and logistic regression (Wald Chi2test, OR, −95%CL, +95% CL). Concentrations of CC chemokines were similar in all examined neonates. Concentrations of CXC chemokines were higher in neonates born by normal spontaneous vaginal delivery (without any anesthesia). MIP-1α and MIP-1β were lower but not significantly both in urgent (systemic anesthesia) and scheduled (epidural anesthesia) cesarean section. RANTES concentrations were also lower in cesarean section (p=0,00001), but similar in urgent and scheduled cesarean section. Model of logistic regression of RANTES concentration in the umbilical cord blood neonates born vaginally and by cesarean section showed significant odds ratio (OR = 6,83; −95%CL= 3,34; +95% CL =13,97; p=0,00005). Vaginal delivery promotes the production of CXC chemokines, mainly RANTES, which are implicated in neonatal immunity. Mother’s anesthesia during cesarean section does not alter chemoattractant cytokines in the cord blood of neonates. Cesarean section, perhaps injury stress or others mediators (immunologic, endocrine, oxygen) may down regulate CXC chemokines.

scholarly journals Adiponectin levels in maternal serum and umbilical cord blood at birth by mode of delivery: relationship to anthropometric measurements and fetal sex

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Seyedeh Razieh Fazeli Daryasari ◽  
Najmeh Tehranian ◽  
Anoshirvan Kazemnejad ◽  
Fatemeh Razavinia ◽  
Fatemeh Tork Tatari ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Cord Blood ◽  
Cesarean Delivery ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Mode Of Delivery ◽  
Maternal Serum ◽  
Anthropometric Measurements ◽  
Fetal Sex

Abstract Background The rate of cesarean section is increasing worldwide. Adiponectin is a hormone related to anti-inflammatory and anti-atherogenic effects; and it′s concentrations may change in response to inflammatory situations including surgical intervention. The aim of the current study was to investigate serum adiponectin levels in maternal and umbilical cord blood according to different modes of delivery and their relationship with anthropometric measurements and fetal sex. Methods The study population initially comprised 90 healthy pregnant women referred to the teaching hospital. Eventually, 40 participants in the vaginal delivery group and 35 subjects in the cesarean delivery group were recruited in to the study. Umbilical cord blood and maternal serum samples were analyzed according to the standard protocol from the manufacturer. The collected data were analyzed using SPSS-16 software. P-value < 0.05 was considered as the significance level for all tests. Results Our results indicated a significant association between maternal adiponectin and the mode of delivery, with adiponectin levels significantly higher in vaginal delivery compared to cesarean section (P < 0.001). However, no difference was found in umbilical cord blood adiponectin between the two groups (P = 0.51). A significant positive correlation was found between maternal serum adiponectin in the first day after birth and umbilical cord blood adiponectin in the vaginal delivery group (P = 0.007). Nevertheless, this correlation was not statistically significant in the cesarean delivery group (P = 0.62). There was also no significant correlation between fetal sex and anthropometric measurements with maternal adiponectin (P = 0.44) and umbilical cord blood adiponectin (P = 0.86). Conclusions The result of the current study revealed that maternal adiponectin concentration was significantly higher in vaginal delivery compared to cesarean section, which might be due to the increased levels of maternal adiponectin release during labor.

scholarly journals Comparison of interleukin-10 and interleukin-13 in cord blood of infants born by vaginal delivery and caesarean

2016 ◽  
Author(s):  
Nastaran Khosravi ◽  
nastaran Khosravi ◽  
Hamid Sheykholeslami ◽  
Mohammad Nabavi ◽  
Alireza Karimi
Keyword(s):  
Cesarean Section ◽  
Cord Blood ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Mode Of Delivery ◽  
Interleukin 10 ◽  
Normal Vaginal Delivery ◽  
Blood Levels ◽  
Significant Difference

Background: The present study assessed the levels of IL-13 and IL-10 in umbilical cord blood of infants born through normal vaginal delivery and infants born with cesarean section.   </p> <p>Methods: This pilot study was performed on 42 neonates born at Rasool-e-Akram hospital between May 2013 and May 2014 categorized into two groups born by vaginal delivery (n = 21) and those who born by cesarean section (n = 21).</p> <p>Results: No difference was observed between the two groups with normal vaginal delivery and cesarean delivery in the level of IL-13 in umbilical cord blood (1.42 {plus minus} 0.23 versus 1.40 {plus minus} 0.22, respectively, p = 0.785). The mean level of IL-10 in umbilical cord blood in the group with vaginal delivery was 6.35 {plus minus} 2.54 and in another group with cesarean section was 5.69 {plus minus} 2.42 with no significant difference (p = 0.393). According to the multivariate linear regression analyses, no difference was found between the two groups of the mode of delivery in the level of IL-10 (beta = -0.454, SE = 0.802, p = 0.575) and also in the level of IL-13 (beta = 0.012, SE = 0.076, p = 0.877). None of the indicators including gestational age, mother's age, sex of neonate, number of live births, history of abortion, and number of parity could predict increased level of the interleukins in umbilical cord blood. </p> <p>Conclusion: Mode of delivery may not be an indicator for altering cord blood levels of IL-13 and IL-10. 

Oxygen Consumption in Platelets of Newborn Infants before and after Stimulation by Thrombin.

1976 ◽  
Vol 35 (03) ◽  
pp. 712-716 ◽  
Author(s):  
D. Del Principe ◽  
G Mancuso ◽  
A Menichelli ◽  
G Maretto ◽  
G Sabetta
Keyword(s):  
Oxygen Consumption ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Newborn Infant ◽  
Umbilical Cord Blood ◽  
Newborn Infants ◽  
O2 Consumption ◽  
Adult Control ◽  
Healthy Newborn ◽  
Before And After

SummaryThe authors compared the oxygen consumption in platelets from the umbilical cord blood of 36 healthy newborn infants with that of 27 adult subjects, before and after thrombin addition (1.67 U/ml). Oxygen consumption at rest was 6 mμmol/109/min in adult control platelets and 5.26 in newborn infants. The burst in oxygen consumption after thrombin addition was 26.30 mμmol/109/min in adults and 24.90 in infants. Dinitrophenol did not inhibit the burst of O2 consumption in platelets in 8 out of 10 newborn infants, while the same concentration caused a decrease in 9 out of 10 adult subjects. Deoxyglucose inhibited the burst in O2 consumption in newborn infant and adult platelets by about 50%. KCN at the concentration of 10−4 M completely inhibited basal oxygen consumption but did not completely inhibit the burst after thrombin. At the concentration of 10−3 M, it inhibited both basal O2 consumption and the burst in infants and adult subjects.

scholarly journals 95 High Copeptin (Arginine-Vasopressin) Concentrations in Umbilical Cord Blood After Vaginal Delivery and Birth Acidosis

2010 ◽  
Vol 68 ◽  
pp. 50-51
Author(s):  
S Wellmann ◽  
J Benzing ◽  
G Cippa ◽  
D Admaty ◽  
R Creutzfeldt ◽  
...  
Keyword(s):  
Cord Blood ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Arginine Vasopressin

Impact On Mother-Baby Parameters in Total Nuclear and CD34+ Cell Count in Umbilical Cord Blood Banking.

Blood ◽  
2009 ◽  
Vol 114 (22) ◽  
pp. 3221-3221
Author(s):  
Christian Villanueva ◽  
John Pando ◽  
Patricia Saenz ◽  
Hugo Rios ◽  
Maria Márquez ◽  
...  
Keyword(s):  
Cord Blood ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Physiological Parameters ◽  
Blood Banking ◽  
Cd34 Cells ◽  
Term Delivery ◽  
Cord Blood Banking ◽  
The Impact

Abstract Abstract 3221 Poster Board III-158 Introduction Umbilical cord blood (UCB) has become an easily, available and viable source of hematopoeitic stem cells for transplant. The main limitation factor for its wide use is cell dose. Previous studies have showed that certain physiological parameters pertaining to either the baby or the mother impact in the UCB cell yields. Objectives The aim of our study was to compare five physiological parameters pertaining to the mother or baby (mother`s age [MA], gestational age at delivery [GA], baby`s gender [G], baby`s birth weight [BW] and type of delivery [TD]) with total nuclear cells (TNC) and CD34 + cells recovery. We also evaluated the impact of time from collection to processing (TCP) on CD45+ cells viability. Methods UCB product collection was performed after the baby's delivery, while the placenta was still in uterus, either from vaginal or cesarean deliveries. Collection bags that were used contained 35 mL of CFDA-1 (CFD with Adenina) as anticoagulant. Cord blood units (CBU) were processed in our institution under local and international regulations regarding cord blood banking. Usual techniques with HES 6% for red cell depletion and 4°C centrifugation for plasma depletion were used. Twenty-five ml, EVA, two-compartment cord blood cells freezing bags (Pall Medical) were used for a final CBU volume of 20.5 ml combined with Dextran 40/40 and DMSO for cryopreservation. A sample was removed for flow cytometric analysis (BD FACSCan) and to determine the TNC (Cell-dyn 1200). Cultures pre and post CBU handling were done. Freezing took place in a controlled-rate freezer according to standard protocol before storage in liquid nytrogen. Results From May 2004 to Jun 2009, a total of 4,262 continous UCB collections were performed in our institution throught the Peruvian Republic. Seventy-eight percent of the CBU were collected by cesarean; median TCP was 30 hours 58 minutes. The mean CBU volume and TNC count were 81.8 ml and 8.63 × 108 respectively. The colected volume was greater in cesarean than vaginal delivery (85.3 ml vs 78.9, F=30.82, p<0.001). TNC counts collected were directly correlated with GA: in preterm delivery (<37sem) was 7.13×108, in term delivery (>=37sem) was 9.93×108. TNC counts were directly correlated with BW (F=325, p<0.001) while the MA had inverse correlation (F=8.05, p=0.005); regarding TD there was a significant mayor TNC count in the vaginal vs. cesarean group (10.49×108 vs. 9.22×108, F=48.207, p<0.001); while it was a trend for major TNC count in females vs. males babies (9.82×108 vs. 9.13×108, p=0.059). CD34+ cells count was directly correlated with BW (F=70.1, p<0.001). The strongest correlation was with GA (in preterm: 61.99 CD34+/ul and in term delivery: 84.67 CD34+/ul, F=27.62 p=<0.001); moreover, there was association between CD34+ cells count with TD (vaginal: 87.88 CD34+/ul vs cesarean: 80.26 CD34+/ul, F=5.327 p=0.02). There was not association either with G (females: 79.97 CD34+/ul vs males: 83.48 CD34+/ul, F=1.668 p=0.197) neither MA (F=1.82, p=0.177). There was a significant difference between CD34+ viability cells among CBU with less than 48 hours or more of TCP (99.6% vs. 99.4%, p=0.019); this difference was stronger when the CD45+ viability was evaluated (93.35% vs. 90.14%, p<0,001). Conclusions TNC and CD34+ UCB cells are influenced by many variables related to the mother and the baby. It looks like on time female babies with good weight, born to a younger mother and from a vaginal delivery reach highest TNC count. CD34+ cells count was directly correlated with BW and CD34+ viability is mainly influenced by the time from collection to processing Disclosures No relevant conflicts of interest to declare.

Umbilical cord blood acid-base balance and gas composition in relation to the use of epidural analgesia in vaginal delivery

2019 ◽  
Vol 5_2019 ◽  
pp. 70-76
Author(s):  
Tysyachnyy O.V. Tysyachnyy ◽  
Baev O.R. Baev ◽  
Evgrafova A.V. Evgrafova ◽  
Prikhodko A.M. Prikhodko ◽  
Pismensky S.V. Pismensky S ◽  
...  
Keyword(s):  
Epidural Analgesia ◽  
Cord Blood ◽  
Vaginal Delivery ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Gas Composition ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

Umbilical cord blood collection in Cesarean section: a comparison before and after placental delivery

2002 ◽  
Vol 266 (4) ◽  
pp. 193-194 ◽  
Author(s):  
C. Pafumi ◽  
G. Milone ◽  
I. Maggi ◽  
R. Mancari ◽  
M. Farina ◽  
...  
Keyword(s):  
Cesarean Section ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Collection ◽  
Before And After ◽  
Cord Blood Collection
Sign in / Sign up

Export Citation Format

Share Document