scholarly journals Transient Suppression of TGFβ Receptor Signaling Facilitates Human Islet Transplantation

Endocrinology ◽  
2016 ◽  
Vol 157 (4) ◽  
pp. 1348-1356 ◽  
Author(s):  
Xiangwei Xiao ◽  
Shane Fischbach ◽  
Zewen Song ◽  
Iljana Gaffar ◽  
Ray Zimmerman ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Human Islet ◽  
Receptor Signaling ◽  
Tgfβ Receptor ◽  
Human Islet Transplantation

Human Islet Transplantation: Current Status and Future Direction

2013 ◽  
Vol 5 (3) ◽  
pp. 156-161
Author(s):  
James McGarrigle ◽  
Jose Oberholzer
Keyword(s):  
Islet Transplantation ◽  
Human Islet ◽  
Current Status ◽  
Human Islet Transplantation ◽  
Future Direction

Engraftment Site and Effectiveness of the Pan-Caspase Inhibitor F573 to Improve Engraftment in Mouse and Human Islet Transplantation in Mice

2017 ◽  
Vol 101 (10) ◽  
pp. 2321-2329 ◽  
Author(s):  
Andrew R. Pepper ◽  
Antonio Bruni ◽  
Rena Pawlick ◽  
John Wink ◽  
Yasmin Rafiei ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Human Islet ◽  
Caspase Inhibitor ◽  
Human Islet Transplantation

scholarly journals Porous Scaffolds Support Extrahepatic Human Islet Transplantation, Engraftment, and Function in Mice

2013 ◽  
Vol 22 (5) ◽  
pp. 811-819 ◽  
Author(s):  
Romie F. Gibly ◽  
Xiaomin Zhang ◽  
William L. Lowe ◽  
Lonnie D. Shea
Keyword(s):  
Islet Transplantation ◽  
Human Islet ◽  
Porous Scaffolds ◽  
Human Islet Transplantation ◽  
And Function

scholarly journals Islet Cell Hormonal Responses to Hypoglycemia After Human Islet Transplantation for Type 1 Diabetes

Diabetes ◽  
2005 ◽  
Vol 54 (11) ◽  
pp. 3205-3211 ◽  
Author(s):  
M. R. Rickels ◽  
M. H. Schutta ◽  
R. Mueller ◽  
J. F. Markmann ◽  
C. F. Barker ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Islet Transplantation ◽  
Islet Cell ◽  
Human Islet ◽  
Hormonal Responses ◽  
Human Islet Transplantation

scholarly journals Laparoscopic approach for human islet transplantation into a defined liver segment in type-1 diabetic patients

2003 ◽  
Vol 16 (3) ◽  
pp. 186-190 ◽  
Author(s):  
Babak Movahedi ◽  
Bart Keymeulen ◽  
Mary-Helen Lauwers ◽  
Eva Goes ◽  
Nadine Cools ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Laparoscopic Approach ◽  
Human Islet ◽  
Diabetic Patients ◽  
Liver Segment ◽  
Human Islet Transplantation ◽  
Type 1 Diabetic Patients

scholarly journals Decreased Survival of Islet Allografts in Rats with Advanced Chronic Complications of Diabetes

2002 ◽  
Vol 11 (7) ◽  
pp. 707-713 ◽  
Author(s):  
Wayne V. Moore ◽  
Karen Bieser ◽  
Zhoahui Geng ◽  
Pei Y. Tong ◽  
Karen Kover
Keyword(s):  
Islet Transplantation ◽  
Acute Onset ◽  
Human Islet ◽  
Allograft Survival ◽  
Chronic Complications ◽  
Islet Allograft ◽  
Complications Of Diabetes ◽  
Onset Diabetes ◽  
Islet Allografts ◽  
Human Islet Transplantation

Successful islet transplantation has been possible in experimental animals in contrast to humans. One difference between animal models of diabetes and human islet transplantation is the presence of advanced chronic complications in humans. Even longer-term follow-up of islet transplantation in humans according to the Edmonton protocol suggests that advanced chronic complications may adversely affect allograft survival with the glucocorticoid-free immunosuppressive regimen as well. We developed a rat model of chronic complications of diabetes and compared islet allograft survival in rats with advanced chronic complications to age-matched control rats with acute onset diabetes. Islets were transplanted at either the renal supcapsular, intrahepatic, or intramuscular location. The survival of islet allografts in rats with chronic complications was decreased at all sites compared with the age-matched controls. The best survival in the rats with advanced chronic complications occurred at the renal subcapsular site. Blood sugar measurements indicated impaired glucose tolerance in most of the rats with chronic complications and surviving renal subcapsular islet allograft. Histological and gross examination of the surviving renal subcapsular islet allografts indicated disordered angiogenesis in the rats with chronic complications. Rats with successful intrahepatic islet allografts and the respective age-matched controls had comparable blood sugars. Survival of islet allografts at the intramuscular site was poor in rats with chronic complications or acute onset diabetes. We conclude that the structural or metabolic abnormalities associated with chronic poor control of diabetes impair islet allograft survival and function. This should be considered as a possible explanation for failure of islet allograft survival in human islet transplantation.

HUMAN ISLET TRANSPLANTATION: LESSONS FROM 13 AUTO- AND 11 ALLOTRANSPLANTATIONS

1999 ◽  
Vol 67 (7) ◽  
pp. S224
Author(s):  
J. Oberholzer ◽  
F. Triponez ◽  
N. Crétin ◽  
L. Bühler ◽  
B. Fournier ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Human Islet ◽  
Human Islet Transplantation

Experience with human islet transplantation in Sweden

2001 ◽  
Vol 33 (4) ◽  
pp. 2535-2536 ◽  
Author(s):  
A Tibell ◽  
J Bolinder ◽  
E Hagström-Toft ◽  
J Tollemar ◽  
M Brendel ◽  
...  
Keyword(s):  
Islet Transplantation ◽  
Human Islet ◽  
Human Islet Transplantation
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