Effects of Antibodies to Bovine Thyroid Plasma Membranes onin VitroBasal and Thyroid-Stimulating Hormone Stimulation of Bovine Thyroid Adenylate Cyclase*

Endocrinology ◽  
1980 ◽  
Vol 107 (3) ◽  
pp. 707-713 ◽  
Author(s):  
HIROSHI MUTOH ◽  
YASUO TOTSUKA ◽  
M. C. Y CHOU ◽  
JAMES B. FIELD
Keyword(s):  
Adenylate Cyclase ◽  
Plasma Membranes ◽  
Thyroid Stimulating Hormone ◽  
Hormone Stimulation ◽  
Bovine Thyroid ◽  
Stimulation Of ◽  
Stimulating Hormone

Studies of thyroid-stimulating hormone binding to bovine thyroid plasma membranes

Metabolism ◽  
1975 ◽  
Vol 24 (8) ◽  
pp. 959-971 ◽  
Author(s):  
Masanobu Kotani ◽  
Toshitsugu Kariya ◽  
James B. Field
Keyword(s):  
Plasma Membranes ◽  
Thyroid Stimulating Hormone ◽  
Hormone Binding ◽  
Bovine Thyroid ◽  
Stimulating Hormone

The biological activity of glucagon–phospholipid complexes

1983 ◽  
Vol 61 (7) ◽  
pp. 688-691 ◽  
Author(s):  
J. J. Liepnieks ◽  
P. Stoskopf ◽  
E. A. Carrey ◽  
C. Prosser ◽  
R. M. Epand
Keyword(s):  
Biological Activity ◽  
Adenylate Cyclase ◽  
Plasma Membranes ◽  
Bovine Brain ◽  
Water Soluble ◽  
Dipalmitoyl Phosphatidylcholine ◽  
Dimyristoyl Phosphatidylcholine ◽  
Lipoprotein Complex ◽  
Stimulation Of

Glucagon can form water-soluble complexes with phospholipids. The incorporation of glucagon into these lipoprotein particles reduces the biological activity of the hormone. The effect is observed only at temperatures below the phase transition temperature of the phospholipid and results in a decreased stimulation of the adenylate cyclase of rat liver plasma membranes by the lipoprotein complex as compared with the hormone in free solution. Two- to five-fold higher concentrations of glucagon are required for half-maximal stimulation of adenylate cyclase when the hormone is complexed with dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, or bovine brain sphingomyelin. A possible role of lipoprotein-associated hormones in the development of insulin resistance is discussed.

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