Institution of Combined Treatment with Testosterone and Charcoal-Extracted Porcine Follicular Fluid Immediately after Orchidectomy Prevents the Postcastration Hyper secretion of Follicle-Stimulating Hormone in the Hypothalamus-Lesioned Rhesus Monkey (Macaca mulatto) Receiving an Invariant Intravenous Gonadotropin-Releasing Hormone Infusion*

Endocrinology ◽  
1989 ◽  
Vol 124 (3) ◽  
pp. 1310-1318 ◽  
Author(s):  
S. A. ABEYAWARDENE ◽  
T. M. PLANT
Keyword(s):  
Rhesus Monkey ◽  
Follicular Fluid ◽  
Follicle Stimulating Hormone ◽  
Combined Treatment ◽  
Gonadotropin Releasing Hormone ◽  
Releasing Hormone ◽  
Macaca Mulatto ◽  
Stimulating Hormone

Responses of luteinizing hormone (LH) and follicle-stimulating hormone levels to exogenous gonadotropin-releasing hormone during the estrogen-induced LH surge in the ovariectomized rhesus monkey

1989 ◽  
Vol 67 (2) ◽  
pp. 135-139 ◽  
Author(s):  
Richard F. Weick ◽  
Vaclav Pitelka ◽  
David L. Thompson
Keyword(s):  
Luteinizing Hormone ◽  
Rhesus Monkey ◽  
Negative Feedback ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Gonadotropin Secretion ◽  
Lh Surge ◽  
Releasing Hormone ◽  
Acute Response ◽  
Stimulating Hormone

Experiments were performed to study the responsiveness of the pituitary to gonadotropin-releasing hormone (GnRH) during the dynamic changes in gonadotropin secretion associated with the estrogen-induced luteinizing hormone (LH) surge in the ovariectomized (OVX) rhesus monkey. Silastic capsules filled with estradiol-17-β were implanted subcutaneously in ovariectomized rhesus monkeys, resulting in an initial lowering of circulating LH and follicle-stimulating hormone (FSH) concentrations followed by an LH–FSH surge. GnRH was injected intravenously just before estrogen implantation, during the negative feedback response and during the rising, the peak, and the declining phases of the LH surge. The LH and FSH responses during the negative feedback phase were as large as those before estrogen treatment (control responses). During the rising phase of the LH surge, the acute response to GnRH injection did not differ significantly from the control response, but the responses 60 and 120 min after injection were somewhat increased. During the declining phase of the LH surge, the pituitary was not responsive to exogenous GnRH, although LH probably continued to be secreted at this time since the LH surge decreased more slowly than predicted by the normal rate of disappearance of LH in the monkey. We conclude that an increased duration of response to GnRH may be an important part of the mechanism by which estrogen induces the LH surge, but we do not see evidence of increased sensitivity of the pituitary to GnRH as an acute releasing factor at that time.Key words: LH surge, GnRH, FSH, ovariectomized monkey.

scholarly journals Role of Kisspeptin in Puberty in Humans

2020 ◽  
pp. 92-97
Author(s):  
Ravi Kant ◽  
Mahendra Kumar Meena
Keyword(s):  
Reproductive Biology ◽  
Conventional Treatment ◽  
Hypogonadotropic Hypogonadism ◽  
Follicle Stimulating Hormone ◽  
Gonadotropin Releasing Hormone ◽  
Pilot Studies ◽  
Releasing Hormone ◽  
Infertile Couples ◽  
Stimulating Hormone

Kisspeptin or GPR-54 is a product of KISS 1 gene regulating the production of gonadotropin releasing hormone (GnRH), luteinizing (LH) as well follicle stimulating hormone (FSH). Both LH and FSH are important hormones for reproduction in animals as well in humans. The recognition of Kisspeptin has a landmark bearing in reproductive biology. Few recent pilot studies have convincingly proven it to be a promising molecule in treating infertile couples especially those having hypogonadotropic hypogonadism not responding to conventional treatment.

Sign in / Sign up

Export Citation Format

Share Document