scholarly journals Monosomy for the X-Chromosome Is Associated with an Atherogenic Lipid Profile

2006 ◽  
Vol 91 (8) ◽  
pp. 2867-2870 ◽  
Author(s):  
Phillip L. Van ◽  
Vladimir K. Bakalov ◽  
Carolyn A. Bondy
Keyword(s):  
Particle Size ◽  
Lipid Profile ◽  
X Chromosome ◽  
Premature Ovarian Failure ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Ovarian Failure ◽  
Atherogenic Lipid Profile ◽  
Lipid Particle ◽  
Atherogenic Lipid

Abstract Context and Objective: Men typically have a more atherogenic lipid profile than women characterized by higher low-density lipoprotein (LDL) cholesterol and triglyceride levels and reduced lipid particle size, contributing to a greater risk for coronary disease. To determine whether X-chromosomal gene dosage affects lipid metabolism independent of sex steroid effects, we compared lipid profiles in age- and body mass-matched young women with ovarian failure, differing only in X-chromosome dosage. Design, Setting, and Patients: Women with premature ovarian failure associated with monosomy X or Turner syndrome (TS, n = 118) were compared with women with 46,XX premature ovarian failure (n = 51) in an in-patient clinical research center unit at the National Institutes of Health. These women were normally on estrogen replacement treatment but discontinued the estrogen 2 wk before study. Major Outcomes: Fasting lipid levels and nuclear magnetic resonance lipid particle profiles in the two study groups were the major outcomes. Results: Average age and body mass were similar in the two groups of women, but LDL cholesterol (P = 0.001) and triglyceride levels (P = 0.0005) were higher in the TS group. Also among women with TS, average LDL particle size was reduced (P < 0.0001) and LDL particle concentration increased, with a 2-fold increase in the smallest particle categories (P < 0.0001). Whereas total high-density lipoprotein cholesterol levels were similar, high-density lipoprotein particle size was significantly smaller in women with TS, compared with women with premature ovarian failure (P < 0.0001). Conclusions: Women with 45,X with ovarian failure exhibit a distinctly more atherogenic lipid profile than 46,XX women with ovarian failure, suggesting that the second X-chromosome contributes to a more salutary lipid profile in normal women, independent of sex steroid effects.

scholarly journals A More Atherogenic Serum Lipoprotein Profile Is Present in Women with Polycystic Ovary Syndrome: A Case-Control Study

2008 ◽  
Vol 93 (2) ◽  
pp. 470-476 ◽  
Author(s):  
Olivier Valkenburg ◽  
Regine P. M. Steegers-Theunissen ◽  
Huberdina P. M. Smedts ◽  
Geesje M. Dallinga-Thie ◽  
Bart C. J. M. Fauser ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Ldl Cholesterol ◽  
Case Control Study ◽  
Polycystic Ovary ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Ovary Syndrome ◽  
Atherogenic Lipid Profile ◽  
Control Study ◽  
Atherogenic Lipid

Abstract Context: Polycystic ovary syndrome (PCOS) is associated with a higher frequency of cardiovascular risk factors. Apolipoprotein (apo) A-I and apoB are potent markers for cardiovascular risk. Data on apo levels in women with PCOS are scarce and contradictory. Objective: Our objective was to identify changes in lipid metabolism in women with PCOS, and the relative impact of obesity, insulin resistance, and hyperandrogenism on lipid parameters. Design: This was a case-control study. Setting: The study was performed at a single referral center. Subjects: PCOS was diagnosed according to the 2003 Rotterdam criteria. Healthy mothers with regular menstrual cycles served as controls. Main Outcome Parameters: Fasting insulin, triglycerides (TGs), cholesterol, high-density lipoprotein (HDL)-cholesterol, apoA-I, and apoB were determined. Low-density lipoprotein (LDL)-cholesterol was calculated using the Friedewald formula. Results: We included 557 women with PCOS and 295 controls. After correction for age and body mass index, PCOS women had higher median levels of insulin (10.1 vs. 6.9 mU/liter), TGs (95 vs. 81 mg/dl), cholesterol (196 vs. 178 mg/dl), and LDL-cholesterol (125 vs. 106 mg/dl) in combination with lower levels of HDL-cholesterol (46 vs. 55 mg/dl) and apoA-I (118 vs. 146 mg/dl) compared with controls (all P values ≤ 0.01). apoB levels were similar in cases and controls. Free androgen index, body mass index, SHBG, and estradiol were independent predictors of apoA-I levels in women with PCOS. Conclusions: PCOS is associated with a more pronounced atherogenic lipid profile. Furthermore, obesity and hyperandrogenism contribute to an adverse lipid profile. Finally, PCOS seems to constitute an additional risk factor for an atherogenic lipid profile.

scholarly journals Advanced Lipoprotein Analysis Shows Atherogenic Lipid Profile That Improves After Metreleptin in Patients with Lipodystrophy

2019 ◽  
Vol 3 (8) ◽  
pp. 1503-1517 ◽  
Author(s):  
Alexandra B Kinzer ◽  
Robert D Shamburek ◽  
Marissa Lightbourne ◽  
Ranganath Muniyappa ◽  
Rebecca J Brown
Keyword(s):  
Insulin Resistance ◽  
High Density Lipoprotein ◽  
Lipid Profile ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Profile ◽  
Cvd Risk ◽  
Lipoprotein Particles ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

Abstract Context Patients with lipodystrophy have dyslipidemia and insulin resistance. Leptin treatment with metreleptin in lipodystrophy decreases insulin resistance and lowers triglycerides without changing high-density lipoprotein. Detailed measurement of lipoprotein particles with nuclear magnetic resonance (NMR) spectroscopy can offer insights into cardiovascular disease (CVD) risk and lipid metabolism beyond a standard lipid panel. We hypothesized that patients with lipodystrophy would have a more atherogenic lipid profile than controls at baseline, which would be ameliorated with metreleptin treatment. Objective To characterize the lipoprotein profile in patients with lipodystrophy compared with controls and to evaluate effects of metreleptin treatment. Design, Setting, Patients, and Intervention Patients with lipodystrophy (N = 17) were studied before and after metreleptin for 2 weeks and 6 months and compared with 51 insulin-sensitive sex-matched controls. Main Outcome Measures Lipoprotein profiles were measured by NMR with the LP4 deconvolution algorithm, which reports triglyceride-rich lipoprotein particles (TRLPs), high-density lipoprotein particles (HDLPs), and low-density lipoprotein particles (LDLPs). Results Patients with lipodystrophy had elevated large TRLPs and smaller HDLPs and LDLPs compared with controls. Five patients with lipodystrophy had chylomicrons, compared with zero controls. Metreleptin decreased the size and concentration of TRLPs, eliminated chylomicrons in all but one patient, decreased LDLPs, and increased LDLP size. Metreleptin treatment did not have major effects on HDLPs. Conclusions Patients with lipodystrophy had an atherogenic lipoprotein profile at baseline consistent with elevated CVD risk, which improved after metreleptin treatment. The presence of fasting chylomicrons in a subset of patients with lipodystrophy suggests saturation of chylomicron clearance by lipoprotein lipase.

W02-O-002 The APOB-516C/T polymorphism isassociated with a more atherogenic lipid profile in males independently of the consumption of dietary fat

2005 ◽  
Vol 6 (1) ◽  
pp. 7
Author(s):  
P. Perez-Martinez ◽  
J. Lopez-Miranda ◽  
A. Lozano ◽  
J.A. Moreno ◽  
C. Bellido ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Dietary Fat ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

scholarly journals A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup

2017 ◽  
Vol 21 (2) ◽  
pp. 73-75
Author(s):  
S Vinod Babu ◽  
Anusha R Jagadeesan ◽  
Jothimalar Ramalingam
Keyword(s):  
Comparative Study ◽  
Lipid Profile ◽  
Total Cholesterol ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
P Value ◽  
Health Checkup ◽  
Group I ◽  
Significant Difference

ABSTRACT Introduction Obesity is emerging as an epidemic worldwide. Obesity is associated with a number of comorbid conditions, such as diabetes mellitus, hypertension, cancer, dyslipidemia, cardiovascular abnormalities, anemia, obstructive sleep apnea, and psychosocial abnormalities. Aim This study aims at comparing the lipid profile levels of obese and nonobese men. Materials and methods This was a case—control study conducted at a tertiary care center. Totally, 80 men in the age group of 20 to 47 years attending the master health checkup were included in the study, out of which 40 men with normal body mass index (BMI) of 18 to 25 belonged to group I and 40 men with increased BMI of 30 and above belonged to group II. Lipid profile parameters, such as triglycerides (TGLs), total cholesterol, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) cholesterol were estimated in them. The data were statistically analyzed using Statistical Package for the Social Sciences (SPSS) software version 15.0. Results Statistically significant difference was found in the total cholesterol levels with a p-value of 0.040 while the difference in LDL cholesterol was statistically highly significant with a p-value of 0.040. Conclusion Among lipid profile parameters, only total cholesterol and LDL cholesterol showed significant difference between the obese and nonobese individuals. However, the other parameters like HDL cholesterol and TGLs did not show any significant difference. How to cite this article Babu SV, Jagadeesan AR, Ramalingam J. A Comparative Study of Lipid Profile in Obese and Nonobese Men attending Master Health Checkup. Indian J Med Biochem 2017;21(2):73-75.

scholarly journals Decreased adiponectin levels in familial combined hyperlipidemia patients contribute to the atherogenic lipid profile

2005 ◽  
Vol 46 (11) ◽  
pp. 2398-2404 ◽  
Author(s):  
Gerly M. van der Vleuten ◽  
Lambertus J. H. van Tits ◽  
Martin den Heijer ◽  
Heidi Lemmers ◽  
Anton F. H. Stalenhoef ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Familial Combined Hyperlipidemia ◽  
Atherogenic Lipid Profile ◽  
Atherogenic Lipid

scholarly journals Analysis of X chromosome genomic DNA sequence copy number variation associated with premature ovarian failure (POF)

2010 ◽  
Vol 25 (8) ◽  
pp. 2139-2150 ◽  
Author(s):  
C. R. Quilter ◽  
A. C. Karcanias ◽  
M. R. Bagga ◽  
S. Duncan ◽  
A. Murray ◽  
...  
Keyword(s):  
Copy Number Variation ◽  
Dna Sequence ◽  
X Chromosome ◽  
Premature Ovarian Failure ◽  
Copy Number ◽  
Genomic Dna ◽  
Ovarian Failure ◽  
Number Variation ◽  
Genomic Dna Sequence

scholarly journals Amaranth Oil Increases Total and LDL Cholesterol Levels without Influencing Early Markers of Atherosclerosis in an Overweight and Obese Population: A Randomized Double-Blind Cross-Over Study in Comparison with Rapeseed Oil Supplementation

Nutrients ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 3069
Author(s):  
Monika Dus-Zuchowska ◽  
Jaroslaw Walkowiak ◽  
Anna Morawska ◽  
Patrycja Krzyzanowska-Jankowska ◽  
Anna Miskiewicz-Chotnicka ◽  
...  
Keyword(s):  
Lipid Profile ◽  
Rapeseed Oil ◽  
Ldl Cholesterol ◽  
Density Lipoprotein ◽  
High Sensitivity ◽  
Anthropometric Parameters ◽  
Double Blind ◽  
Early Markers ◽  
Amaranth Oil ◽  
Overweight Subjects

Background: Atherosclerosis (AT) is a chronic inflammatory process in which oxidative stress is the key event. Amaranth oil (AmO) has potential hypolipidemic and antiatherogenic effects. The aim of the study was to compare the effects of AmO and rapeseed oil (RaO) supplementation on expression of early markers of AT and lipid profile in obese or overweight subjects. Methods: A randomized, double-blinded cross-over study was conducted, in which participants took 20 mL of AmO in the first arm and 20 mL RaO in the second arm, switching after the washout period. Serum concentrations of adhesion molecules (sP-selectin, sVCAM-1), high-sensitivity C-reactive protein (hsCRP), asymmetric dimethylarginine (ADMA), and lipid profile were assessed before and after nutritional interventions. In addition, anthropometric parameters were measured. Results: The total (TC) and low-density lipoprotein (LDL) cholesterol concentrations increased significantly in the AmO group in comparison with RaO (ΔTC 5.52 ± 35 vs. −8.43 ± 17.65 mg/dL; p = 0.002 and 4.43 ± 34.96 vs. −7.55 ± 16.41 mg/dL; p = 0.002, respectively). There were no significant differences in other parameters analyzed between the groups. Conclusion: The use of AmO instead of RaO may increase cardiovascular risk in obese and overweight subjects.

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