Metoclopramide-Induced Hyperprolactinemia Impairs Ovarian Follicle Maturation and Corpus Luteum Function in Women*

1982 ◽  
Vol 54 (5) ◽  
pp. 955-960 ◽  
Author(s):  
ANTTI KAUPPILA ◽  
PEKKA LEINONEN ◽  
REIJO VIHKO ◽  
PEKKA YLöSTALO
Keyword(s):  
Corpus Luteum ◽  
Ovarian Follicle ◽  
Follicle Maturation

Effects of external pH on hormonally regulated ovarian follicle maturation and ovulation in Atlantic croaker

2005 ◽  
Vol 141 (2) ◽  
pp. 126-134 ◽  
Author(s):  
Reynaldo Patiño ◽  
Digbo Bolamba ◽  
Peter Thomas ◽  
Naoki Kumakura
Keyword(s):  
Ovarian Follicle ◽  
Atlantic Croaker ◽  
Follicle Maturation ◽  
External Ph

scholarly journals Effect of some Nigerian traditional alcoholic beverages on the estrous cycle and histological assessment of the ovaries and uterus of albino rats

2021 ◽  
Vol 14 (1) ◽  
pp. 027-036
Author(s):  
Olusayo Moritiwon ◽  
Timothy Olugbenga Ogundeko ◽  
James Bitrus ◽  
David Oyebode ◽  
Olufunmilayo Ibiyemi Abobarin
Keyword(s):  
Corpus Luteum ◽  
Estrous Cycle ◽  
Ovarian Follicle ◽  
Alcoholic Beverages ◽  
Albino Rats ◽  
Histological Image ◽  
Follicular Cyst ◽  
Regular Consumption ◽  
Alcoholic Drinks ◽  
Corpus Luteum Cyst

Alcohol related health challenges have lingered over the years. Such associated with locally brewed alcoholic beverages have received little attention. The urgency to explore this becomes imperative. This study aimed at evaluating the effect of regular consumption of local alcoholic beverages on the estrous cycle and histological image of the ovaries and uterus thus fertility of female albino rats. Thirty screened female albino rats weighing 180-220g were divided into five groups and daily administered each with 10ml/kg of pito, burukutu, ogogoro, goskolo and 0.5ml/kg normal saline respectively for 21 days. Effect of the beverages on the estrous cycle as well as histopathological evaluation was carried out on the isolated ovaries and uterus. Results showed significant increase proestrous phase of the estrous cycle with ingestion of pito, burukutu, ogogorogo and goskolo. Also the histology of the ovary was basically without obvious pathological changes with pito, while there was alteration of histological parameters by burukutu, marked with formation of fibrosis, corpus luteum cyst resulting immature ovarian follicle, ogogoro marked with formation of fibrosis, corpus luteum cyst resulting immature ovarian follicle and goskolo marked with formation of multiple follicular cyst resulting in complete collapse of the ovarian section. The effect of traditional alcoholic beverages revealed the classical effects of alcoholic drinks by way of significant alteration in the estrous cycle of albino rats with marked alteration of the histological architecture of ovarian tissues. Pito, burukutu, ogogoro, and goskolo have a reprotoxic effect on the ovaries and uterus thus a deleterious effect on fertility of female albino rats.

Differential expression of Notch component and effector genes during ovarian follicle and corpus luteum development during the oestrous cycle

2015 ◽  
Vol 27 (7) ◽  
pp. 1038 ◽  
Author(s):  
D. Murta ◽  
M. Batista ◽  
E. Silva ◽  
A. Trindade ◽  
L. Mateus ◽  
...  
Keyword(s):  
Corpus Luteum ◽  
Cell Fate ◽  
Ovarian Follicle ◽  
Expression Patterns ◽  
Cell Signalling ◽  
Cell Communication ◽  
Oestrous Cycle ◽  
Specific Expression ◽  
Cell Fate Decisions ◽  
Effector Genes

Ovarian dynamics throughout the female oestrous cycle (EC) are characterised by cyclical follicle and corpus luteum (CL) development. These events are tightly regulated, involving extensive cell-to-cell communication. Notch is an evolutionarily well conserved cell-signalling pathway implicated in cell-fate decisions in several tissues. Here, we evaluated the extra-vascular expression patterns of Notch component and effector genes during follicle and CL development throughout the EC. Five mature CD1 female mice were killed at each EC stage. Blood samples were collected for progesterone measurement, ovaries were processed for immunohistochemistry and expression patterns of Notch components (Notch1, 2 and 3, Jagged1 and Delta-like1 and 4) and effectors (Hes1, Hes2 and Hes5) were characterised. Nuclear detection of Notch effectors indicates that Notch signalling is active in the ovary. Notch components and effectors are differentially expressed during follicle and CL development throughout the EC. The spatial and temporal specific expression patterns are associated with follicle growth, selection and ovulation or atresia and CL development and regression.

STUDIES ON THE GROWTH IN TISSUE CULTURE OF THE CORPUS LUTEUM AND OF THE ISOLATED OVARIAN FOLLICLE OF THE RAT

1961 ◽  
Vol 38 (4) ◽  
pp. 598-610 ◽  
Author(s):  
Stig Kullander
Keyword(s):  
Tissue Culture ◽  
Corpus Luteum ◽  
Steroid Hormones ◽  
Ovarian Follicle ◽  
Ovarian Follicles ◽  
Good Growth ◽  
Hormonal Influence ◽  
Theca Cells ◽  
Ovarian Cells

ABSTRACT The growth of corpus luteum tissue fragments and single ovarian follicles from rat and the hormonal influence on such growth was studied in tissue culture. Both types of tissue gave good growth. Oestrone inhibited the growth of the theca cells around the follicles during dioestrus, but stimulated the growth of the corpus luteum fragments, provided, however, that they had been dissected from rats in dioestrus. Progesterone appeared to inhibit the growth of theca cells from follicles removed from animals in oestrus. F. S. H. inhibited the growth of theca cells from follicles excised from animals in dioestrus, but stimulated the growth of these cells from animals in oestrus. L. T. H. stimulated growth of corpus luteum fragments that had been isolated from animals in oestrus, but had no effect when the specimens had been removed from animals in dioestrus. The findings suggest that steroid hormones and gonadotrophins may directly inhibit or stimulate the growth of certain ovarian cells and that oestrogens are necessary for the gonadotrophic hormones to exert a stimulating effect locally on the ovary.

scholarly journals The role of WNT signaling in adult ovarian folliculogenesis

Reproduction ◽  
2015 ◽  
Vol 150 (4) ◽  
pp. R137-R148 ◽  
Author(s):  
J A Hernandez Gifford
Keyword(s):  
Wnt Signaling ◽  
Hormonal Regulation ◽  
Ovarian Function ◽  
Integration Site ◽  
Ovarian Follicle ◽  
Wnt Signaling Pathway ◽  
Signaling Molecules ◽  
Steroid Production ◽  
Downstream Signaling ◽  
Follicle Maturation

Wingless-type mouse mammary tumor virus integration site (WNT) signaling molecules are locally secreted glycoproteins that play important role in regulation of ovarian follicle maturation and steroid production. Components of the WNT signaling pathway have been demonstrated to impact reproductive functions, including embryonic development of the sex organs and regulation of follicle maturation controlling steroidogenesis in the postnatal ovary. Emerging evidence underscores the complexity of WNT signaling molecules in regulation of dynamic changes that occur in the ovary during the reproductive cycle. While disruption in the WNT signaling cascade has been recognized to have deleterious consequences to normal sexual development, more recent studies are beginning to highlight the importance of these molecules in adult ovarian function related to follicle development, corpus luteum formation, steroid production and fertility. Hormonal regulation of WNT genes and expression of members of the WNT signaling network, including WNT ligands, frizzled receptors, and downstream signaling components that are expressed in the postnatal ovary at distinct stages of the estrous cycle suggest a crucial role in normal ovarian function. Similarly, FSH stimulation of T-cell factor-dependent gene expression requires input from β-catenin, a lynchpin molecule in canonical WNT signaling, further indicating β-catenin participation in regulation of follicle maturation. This review will focus on the multiple functions of WNT signaling in folliculogenesis in the adult ovary.

scholarly journals Ligands, receptors and transcription factors that mediate inter-cellular and intra-cellular communication during ovarian follicle development

2019 ◽  
Author(s):  
Beatriz Peñalver Bernabé ◽  
Teresa Woodruff ◽  
Linda J Broadbelt ◽  
Lonnie D Shea
Keyword(s):  
Transcription Factors ◽  
Ovarian Follicle ◽  
Somatic Cells ◽  
Follicle Development ◽  
Paracrine Signaling ◽  
Oocyte Growth ◽  
Ovarian Follicle Development ◽  
Ovarian Folliculogenesis ◽  
Follicle Maturation

SUMMARYReliably producing a competent oocyte entails a deeper comprehension of ovarian follicle maturation, a very complex process that includes meiotic maturation of the female gamete, the oocyte, together with the mitotic divisions of the hormone-producing somatic cells. In this report, we investigate mice ovarian folliculogenesis in vivo using publically available time-series microarrays from primordial to antral stage follicles. Manually curated protein interaction networks were employed to identify autocrine and paracrine signaling between the oocyte and the somatic cells (granulosa and theca cells) and the oocyte and cumulus and mural cells at multiple stages of follicle development. We established protein binding interactions between expressed genes that encoded secreted factors and expressed genes that encoded cellular receptors. Some of computationally identified signaling interactions are well established, such as the paracrine signaling from the oocyte to the somatic cells through the secreted oocyte growth factor Gdf9; while others are novel connections in term of ovarian folliculogenesis, such as the possible paracrine connection from somatic secreted factor Ntn3 to the oocyte receptor Neo1. Additionally, we identify several of the likely transcription factors that might control the dynamic transcriptome during ovarian follicle development, noting that the YAP/TAP signaling is very active in vivo. This novel dynamic model of signaling and regulation can be employed to generate testable hypotheses regarding follicle development, guide the improvement of culture media to enhance in vitro ovarian follicle maturation and possibly as novel therapeutic targets for reproductive diseases.

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