scholarly journals Kinetic Complexity of the Global Response to Glucocorticoid Receptor Action

2009 ◽  
Vol 94 (3) ◽  
pp. 1053-1053
Author(s):  
Sam John ◽  
Thomas A. Johnson ◽  
Myong-Hee Sung ◽  
Simon C. Biddie ◽  
Saskia Trump ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Global Response ◽  
Receptor Action

scholarly journals Kinetic Complexity of the Global Response to Glucocorticoid Receptor Action

Endocrinology ◽  
2009 ◽  
Vol 150 (4) ◽  
pp. 1766-1774 ◽  
Author(s):  
Sam John ◽  
Thomas A. Johnson ◽  
Myong-Hee Sung ◽  
Simon C. Biddie ◽  
Saskia Trump ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Cellular Response ◽  
Target Gene ◽  
Binary Response ◽  
Global Response ◽  
Gene Response ◽  
Response Profile ◽  
Transcriptional Modulation ◽  
Receptor Action ◽  
Complex Regulation

We have characterized the kinetic response of gene targets throughout the murine genome to transcriptional modulation by the glucocorticoid receptor (GR). In contrast to a model in which multiple genes are either repressed or activated during the GR response, the vast majority of responsive genes are subject to complex regulation profiles, frequently with alternate activation and repression phases. We also observe that GR binding at response elements does not always correlate with the target gene response profile. Thus, the cellular response to GR stimulation involves a highly orchestrated series of regulatory actions and not simply a binary response to hormone.

Regulation of glucocorticoid receptor action by ARID subunits of the SWI/SNF complex

2015 ◽  
Author(s):  
Felicity Ellen Russell ◽  
Becky L Conway-Campbell ◽  
Matthew Birnie ◽  
Simon Biddie ◽  
Stafford Lightman
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Action

Molecular dynamics of ultradian glucocorticoid receptor action

2012 ◽  
Vol 348 (2) ◽  
pp. 383-393 ◽  
Author(s):  
Becky L. Conway-Campbell ◽  
John R. Pooley ◽  
Gordon L. Hager ◽  
Stafford L. Lightman
Keyword(s):  
Molecular Dynamics ◽  
Glucocorticoid Receptor ◽  
Receptor Action

scholarly journals Anti-Inflammatory Chromatinscape Suggests Alternative Mechanisms of Glucocorticoid Receptor Action

Immunity ◽  
2017 ◽  
Vol 47 (2) ◽  
pp. 298-309.e5 ◽  
Author(s):  
Kyu-Seon Oh ◽  
Heta Patel ◽  
Rachel A. Gottschalk ◽  
Wai Shing Lee ◽  
Songjoon Baek ◽  
...  
Keyword(s):  
Glucocorticoid Receptor ◽  
Receptor Action ◽  
Anti Inflammatory

scholarly journals Incoherent feed-forward regulatory logic underpinning glucocorticoid receptor action

2013 ◽  
Vol 110 (5) ◽  
pp. 1964-1969 ◽  
Author(s):  
S.-h. Chen ◽  
K. Masuno ◽  
S. B. Cooper ◽  
K. R. Yamamoto
Keyword(s):  
Glucocorticoid Receptor ◽  
Feed Forward ◽  
Receptor Action
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