Studies on Experimental Concussion: Relation of Physiologic Effect to Time Duration of Intracranial Pressure Increase at Impact

Neurology ◽  
1954 ◽  
Vol 4 (9) ◽  
pp. 674-674 ◽  
Author(s):  
E. S. Gurdjian ◽  
H. R. Lissner ◽  
J. E. Webster ◽  
F. R. Latimer ◽  
B. F. Haddad
Keyword(s):  
Intracranial Pressure ◽  
Pressure Increase ◽  
Time Duration ◽  
Physiologic Effect

scholarly journals Intracranial compliance during the post-operative period after surgery for intracranial aneurysms

1979 ◽  
Vol 37 (3) ◽  
pp. 250-254
Author(s):  
Hildo R. C de Azevedo Filho ◽  
Christopher B. T. Adams ◽  
John Kerr
Keyword(s):  
Intracranial Pressure ◽  
Cerebral Vasospasm ◽  
Intracranial Aneurysms ◽  
Continuous Monitoring ◽  
Pressure Increase ◽  
Intracranial Volume ◽  
Operative Results ◽  
Intracranial Compliance ◽  
Post Operative Period ◽  
Ruptured Intracranial Aneurysms

Generalised post-operative cerebral vasospasm is a major factor in delineating poor operative results following direct ruptured intracranial aneurysms. Continuous monitoring of intracranial pressure seems to be particularly helpful on such occasions, and intracranial compliance determination as well. High intracranial compliance values suggest that even small intracranial volume increases may induce rapid intracranial pressure increase and situations likely to produce neurological deterioration.

scholarly journals Methylprednisolone Modulates Intracranial Pressure in the Brain Cellular Edema Induced by Water Intoxication

2017 ◽  
pp. S511-S516 ◽  
Author(s):  
P. KOZLER ◽  
D. MAREŠOVÁ ◽  
J. POKORNÝ
Keyword(s):  
Intracranial Pressure ◽  
Intracranial Hypertension ◽  
Brain Edema ◽  
Continuous Monitoring ◽  
Water Intoxication ◽  
Pressure Increase ◽  
Intracranial Volume ◽  
Pressure Transmitter ◽  
The Brain

Continuous monitoring of the intracranial pressure (ICP) detects impending intracranial hypertension resulting from the impaired intracranial volume homeostasis, when expanding volume generates pressure increase. In this study, cellular brain edema (CE) was induced in rats by water intoxication (WI). Methylprednisolone (MP) was administered intraperitoneally (i.p.) before the start of CE induction, during the induction and after the induction. ICP was monitored for 60 min within 20 h after the completion of the CE induction by fibreoptic pressure transmitter. In rats with induced CE, ICP was increased (MeanSEM: 14.25±2.12) as well as in rats with MP administration before the start of CE induction (10.55±1.27). In control rats without CE induction (4.62±0.24) as well as in rats with MP applied during CE induction (5.52±1.32) and in rats with MP applied after the end of CE induction (6.23±0.73) ICP was normal. In the last two groups of rats, though the CE was induced, intracranial volume homeostasis was not impaired, intracranial volume as well as ICP were not increased. It is possible to conclude that methylprednisolone significantly influenced intracranial homeostasis and thus also the ICP values in the model of cellular brain edema.

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