Aim. assesses bone density (BD), calcium - phosphorus metabolism and bone metabolism in male patients with chronic obstructive pulmonary disease (COPD) of different risk of exacerbation. Materials and methods. Men with COPD GOLD II-III aged 50 to 65 years were examined: group 1 (n = 43) - low risk of exacerbation of COPD, group 2 (n = 62) - high risk of exacerbation of COPD. BD was determined by double X-ray absorptiometry in the area of the lumbar spine in the area L1-L4 and the femoral neck (FN). The content of C-terminal telopeptide (CTX) in blood serum was determined by enzyme immunoassay. The state of calcium-phosphorus metabolism was assessed by the level of concentration of total calcium (Ca), inorganic phosphorus (P) in the blood serum, product Ca × P. Results. Decreased BD in the lumbar spine in the L1-L4 zone and FN among men with COPD was found in 66.7% of cases, of which 30 (42.8%) had osteopenia, 40 (57.1%) had osteoporosis (OP). 28 (26.6%) people had hypocalcemia. In 66 (62.9%) subjects, the CTX value was higher than the threshold value. In group 2 patients, the incidence of OP, hypocalcemia, and increased CTX was higher. A reliable inverse correlation was established between the moderate strength of the frequency of exacerbations with the T-criterion in the L1-L4 zone, FN, BMD L1-L4 and BMD FN. Frequent exacerbations of COPD increase the risks and chances of developing OP, hypocalcemia, and increased CTX. Conclusion. The results obtained indicate a high incidence of decreased BD, impaired calcium-phosphorus metabolism and an increase in the marker of bone resorption CTX among men with COPD, with a predominance in those with a high risk of exacerbation of the disease.