scholarly journals Tumor Resection Guided by Intraoperative Indocyanine Green Dye Fluorescence Angiography Results in Negative Surgical Margins and Decreased Local Recurrence in an Orthotopic Mouse Model of Osteosarcoma

2018 ◽  
Vol 26 (3) ◽  
pp. 894-898 ◽  
Author(s):  
Adel Mahjoub ◽  
Alejandro Morales-Restrepo ◽  
Mitchell S. Fourman ◽  
Jonathan B. Mandell ◽  
Lu Feiqi ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Mouse Model ◽  
Indocyanine Green ◽  
Tumor Resection ◽  
Surgical Margins ◽  
Fluorescence Angiography ◽  
Orthotopic Mouse Model ◽  
Indocyanine Green Dye ◽  
Dye Fluorescence

Full Laparoscopic Anatomical Segment 8 Resection for Hepatocellular Carcinoma Using the Glissonian Approach with Indocyanine Green Dye Fluorescence

2019 ◽  
Vol 26 (8) ◽  
pp. 2577-2578 ◽  
Author(s):  
Giammauro Berardi ◽  
Go Wakabayashi ◽  
Kazuharu Igarashi ◽  
Takehiro Ozaki ◽  
Naoyuki Toyota ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Indocyanine Green ◽  
Indocyanine Green Dye ◽  
Glissonian Approach ◽  
Segment 8 ◽  
Dye Fluorescence

Effects of cytoreductive primary tumor resection in an orthotopic mouse model of metastatic prostate cancer

2021 ◽  
Vol 79 ◽  
pp. S592
Author(s):  
J. Linxweiler ◽  
T. Hajili ◽  
C. Körbel ◽  
P. Zeuschner ◽  
M.D. Menger ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Mouse Model ◽  
Primary Tumor ◽  
Metastatic Prostate Cancer ◽  
Tumor Resection ◽  
Primary Tumor Resection ◽  
Orthotopic Mouse Model

scholarly journals Iliosacral Bone Tumor Resection Using Cannulated Screw-Guided Gigli Saw - A Novel Technique

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Tao Ji ◽  
Brian Z. J. Chin ◽  
Xiaodong Tang ◽  
Rongli Yang ◽  
Wei Guo
Keyword(s):  
Local Recurrence ◽  
Tumor Resection ◽  
Surgical Margins ◽  
Osteotomy Site ◽  
R0 Resection ◽  
Primary Tumors ◽  
Current Series ◽  
Common Diagnosis ◽  
Sacral Foramina

Abstract Background Adequate margins are technically difficult to achieve for malignant tumors involving the sacroiliac joint due to limited accessibility and viewing window. In order to address the technical difficulties faced in iliosacral tumor resection, we proposed a technique for precise osteotomy, which involved the use of canulated screws and Gigli saw (CSGS) that facilitated directional control, anteroposterior linkage of resection points and adequate surgical margins. The purpose of the current study was to evaluate whether CSGS technique facilitated sagittal osteotomy at sacral side, and were adequate surgical margins achieved? Also functional and oncological outcomes was determined along with the noteworthy complications. Methods From April 2018 to November 2019, we retrospectively reviewed 15 patients who underwent resections for primary tumors of pelvis or sacrum necessitating iliosacral joint removal using the proposed CSGS technique. Chondrosarcoma was the most common diagnosis. The osteotomy site within sacrum was at ipsilateral ventral sacral foramina in 8 cases, midline of sacrum in 5 cases, and contralateral ventral sacral foramina and sacral ala with 1 case each. The average intraoperative blood loss was 3640 mL (range, 1200 and 6000 mL) with a mean operation duration of 7.4 hours (range, 5 to 12 hours). The mean follow-up was 23.0 months (range, 18 and 39 months) for alive patients. Results Surgical margins were wide in 12 patients (80%), wide-contaminated in 1 patient (6.7%), and marginal in 2 patients (13.3%). R0 resection was achieved in 12 (80%) patients and R1 resection in 3 patients. There were three local recurrences (20%) occurred at a mean time of 11 months postoperatively. No local recurrence was observed at sacral osteotomy. The overall one-year and three-year survival rate was 86.7% and 72.7% respectively.Complications occurred in three patients. Conclusions The current study demonstrated that CSGS technique for tumor resection within the sacrum and pelvis was feasible and can achieve ideal resection accuracies. The use of CSGS was associated with high likelihood of negative margin resections in the current series. Intraoperative use of CSGS appeared to be technically straightforward and allowed achievement of planned surgical margins. It is worthwhile to consider the use of CSGS technique in resection of pelvic tumors with sacral invasion and iliosacral tumors, however further follow-up at mid to long-term is warranted to observe local recurrence rate.

scholarly journals Photothermal Therapy as Adjuvant to Surgery in an Orthotopic Mouse Model of Human Fibrosarcoma

Cancers ◽  
2021 ◽  
Vol 13 (22) ◽  
pp. 5820
Author(s):  
Marina Simón ◽  
Jesper Tranekjær Jørgensen ◽  
Fredrik Melander ◽  
Thomas Lars Andresen ◽  
Anders Christensen ◽  
...  
Keyword(s):  
Mouse Model ◽  
Photothermal Therapy ◽  
Treatment Options ◽  
Tumor Resection ◽  
Treatment Strategies ◽  
Clinical Situation ◽  
Surrounding Tissue ◽  
Cancer Therapies ◽  
Orthotopic Mouse Model ◽  
Total Tumor Removal

Surgery is still the first-line treatment for multiple solid cancers. However, recurrence is a common issue, especially when dealing with aggressive tumors or tumors that are difficult to completely remove due to their location. Getting clear surgical margins can be challenging, but treatment strategies combining surgery with other anti-cancer therapies can potentially improve the outcome. Photothermal therapy (PTT) is a technique that relies on photoabsorbing agents, such as gold nanoparticles, to transform light into local hyperthermia. This technique can be used to ablate tumor tissue where the photoabsorbing agent accumulates, sparing healthy surrounding tissue. In this study, we examined the potential of gold nanoparticle-based PTT as an adjuvant treatment to surgery in a mouse model of human fibrosarcoma. For this we performed subtotal tumor resection to mimic a clinical situation where total tumor removal is not achieved, and subsequent PTT was applied on the surgical field. Our results showed that animals undergoing adjuvant PTT after surgery presented sustained delayed tumor growth and improved survival when compared to animals that only underwent surgery. We believe that these findings show the potential of PTT as an adjuvant method to traditional tumor surgery and could pave way to more personalized treatment options.

Surgical Resection of Multiple Small Bowel Neuroendocrine Tumours Using Intraoperative Fluorescence Angiography with Indocyanine Green Dye

2020 ◽  
Vol 51 (2) ◽  
pp. 681-684
Author(s):  
Maria Ana Rafael ◽  
Ricardo Rocha ◽  
Ana Maria Oliveira ◽  
Catarina Graça Rodrigues ◽  
Carla Carneiro ◽  
...  
Keyword(s):  
Small Bowel ◽  
Indocyanine Green ◽  
Surgical Resection ◽  
Neuroendocrine Tumours ◽  
Fluorescence Angiography ◽  
Indocyanine Green Dye ◽  
Intraoperative Fluorescence

Kinetics analysis of indocyanine green based on a novel mouse model to distinguish between tumor and inflammation

2019 ◽  
Vol 11 (44) ◽  
pp. 5704-5710 ◽  
Author(s):  
Diya Xie ◽  
Yuxin Wang ◽  
Ziyang Wang ◽  
Jianquan Wang ◽  
Hao Han ◽  
...  
Keyword(s):  
Mouse Model ◽  
Indocyanine Green ◽  
Real Time ◽  
Near Infrared ◽  
Tumor Resection ◽  
Kinetics Analysis ◽  
Nir Imaging

Near-infrared (NIR) imaging with indocyanine green (ICG) has been proven to be feasible for the visualization of tumor and enables real-time guidance during tumor resection.

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