FREE RADICAL PRODUCT FORMED BY THE REACTION OF DEHYDROASCORBIC ACID WITH AMINO ACIDS

1974 ◽  
Vol 3 (2) ◽  
pp. 125-128 ◽  
Author(s):  
Mitsuo Namiki ◽  
Midori Yano ◽  
Tateki Hayashi
Keyword(s):  
Amino Acids ◽  
Free Radical ◽  
Dehydroascorbic Acid ◽  
Radical Product ◽  
Free Radical Product

The alkoxy radical, RCH2Ȯ, as a free radical product in x-irradiated single crystals of nucleosides and nucleotides

1977 ◽  
Vol 67 (3) ◽  
pp. 1211 ◽  
Author(s):  
William A. Bernhard ◽  
David M. Close ◽  
Jürgen Hüttermann ◽  
Herbert Zehner
Keyword(s):  
Free Radical ◽  
Single Crystals ◽  
Alkoxy Radical ◽  
Radical Product ◽  
Free Radical Product

Metabolic Activation of Carbon Tetrachloride to a Free-Radical Product: Studies using a Spin Trap

1978 ◽  
Vol 6 (5) ◽  
pp. 962-964 ◽  
Author(s):  
A. INGALL ◽  
K. A. K. LOTT ◽  
T. F. SLATER ◽  
S. FINCH ◽  
A. STIER
Keyword(s):  
Free Radical ◽  
Carbon Tetrachloride ◽  
Spin Trap ◽  
Metabolic Activation ◽  
Radical Product ◽  
Free Radical Product

Radical reactions of nitric oxide synthases

2004 ◽  
Vol 71 ◽  
pp. 39-49 ◽  
Author(s):  
Dennis J. Stuehr ◽  
Chin-Chuan Wei ◽  
Jerome Santolini ◽  
Zhi- Qiang Wang ◽  
Mika Aoyagi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Electron Transfer ◽  
Free Radical ◽  
Structural Features ◽  
Nitric Oxide Synthases ◽  
Radical Reactions ◽  
Radical Product ◽  
O2 Activation ◽  
Health And Disease ◽  
Free Radical Product

NOSs (nitric oxide synthases) are flavohaem enzymes that function broadly in human health and disease. We are combining mutagenesis, crystallographic and rapid kinetic methods to understand their mechanism and regulation. The NOSs create a transient tetrahydrobiopterin radical within the enzyme to generate their free radical product (NO). Recent work is revealing how critically important this process is at all levels of catalysis. This article will synthesize four seemingly disparate but related aspects of NOS tetrahydrobiopterin radical formation: (i) how it enables productive O2 activation by providing an electron to the enzyme haem, (ii) what structural features help to regulate this electron transfer, (iii) how it enables NOS to synthesize NO from its diamagnetic substrate and (iv) how it allows NOS to release NO after each catalytic cycle instead of other nitorgen oxide-containing products.

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