scholarly journals Electrophysiological effects of KW-3049, a novel dihydropyridine type Ca antagonist, on isolated rabbit hearts, sinus nodal tissues and guinea-pig ventricular muscles.

1986 ◽  
Vol 88 (3) ◽  
pp. 179-187 ◽  
Author(s):  
Ikufumi YOSHITAKE ◽  
Kazuhiro KUBO ◽  
Nobuo IKEDA ◽  
Itsuo KODAMA ◽  
Junji TOYAMA ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Ca Antagonist ◽  
Electrophysiological Effects

Effects of estrogen on action potential and membrane currents in guinea pig ventricular myocytes

1999 ◽  
Vol 277 (2) ◽  
pp. H826-H833 ◽  
Author(s):  
Seiko Tanabe ◽  
Toshio Hata ◽  
Masayasu Hiraoka
Keyword(s):  
Guinea Pig ◽  
Action Potential ◽  
Action Potentials ◽  
Voltage Dependence ◽  
Ventricular Myocytes ◽  
Membrane Currents ◽  
Patch Clamp Technique ◽  
17Β Estradiol ◽  
Electrophysiological Effects ◽  
Ionic Basis

To explore a possible ionic basis for the prolonged Q-T interval in women compared with that in men, we investigated the electrophysiological effects of estrogen in isolated guinea pig ventricular myocytes. Action potentials and membrane currents were recorded using the whole cell configuration of the patch-clamp technique. Application of 17β-estradiol (10–30 μM) significantly prolonged the action potential duration (APD) at 20% (APD20) and 90% repolarization (APD90) at stimulation rates of 0.1–2.0 Hz. In the presence of 30 μM 17β-estradiol, APD20 and APD90 at 0.1 Hz were prolonged by 46.2 ± 17.1 and 63.4 ± 11.7% of the control ( n = 5), respectively. In the presence of 30 μM 17β-estradiol the peak inward Ca2+ current ( I CaL) was decreased to 80.1 ± 2.5% of the control ( n = 4) without a shift in its voltage dependence. Application of 30 μM 17β-estradiol decreased the rapidly activating component of the delayed outward K+ current ( I Kr) to 63.4 ± 8% and the slowly activating component ( I Ks) to 65.8 ± 8.7% with respect to the control; the inward rectifier K+ current was barely affected. The results suggest that 17β-estradiol prolonged APD mainly by inhibiting the I Kcomponents I Krand I Ks.

Electrophysiologic Effects of a Novel Ca Antagonist, SA2572, in Isolated Rabbit and Guinea Pig Hearts

1988 ◽  
Vol 12 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Nobuaki Miyawaki ◽  
Tatsuji Furuta ◽  
Tatsuro Shigei
Keyword(s):  
Guinea Pig ◽  
Ca Antagonist

scholarly journals Electrophysiological Effects of the Class Ic Antiarrhythmic Drug Pilsicainide on the Guinea-Pig Pulmonary Vein Myocardium

2012 ◽  
Vol 118 (4) ◽  
pp. 506-511 ◽  
Author(s):  
Akira Takahara ◽  
Kiyoshi Takeda ◽  
Yayoi Tsuneoka ◽  
Mihoko Hagiwara ◽  
Iyuki Namekata ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Pulmonary Vein ◽  
Antiarrhythmic Drug ◽  
Electrophysiological Effects

Electrophysiological effects of desipramine of guinea pig papillary muscles

1979 ◽  
Vol 55 (2) ◽  
pp. 171-179 ◽  
Author(s):  
J. Tamargo ◽  
S. Rodriguez ◽  
P.Garcia De Jalón
Keyword(s):  
Guinea Pig ◽  
Papillary Muscles ◽  
Electrophysiological Effects

scholarly journals Electrophysiological Effects of an Anti-influenza Drug Oseltamivir on the Guinea-Pig Atrium: Comparison with Those of Pilsicainide

2013 ◽  
Vol 36 (10) ◽  
pp. 1650-1652 ◽  
Author(s):  
Akira Takahara ◽  
Sanae Suzuki ◽  
Mihoko Hagiwara ◽  
Shuhei Nozaki ◽  
Atsushi Sugiyama
Keyword(s):  
Guinea Pig ◽  
Guinea Pig Atrium ◽  
Electrophysiological Effects
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