scholarly journals Effects of Trimebutine Maleate (TM-906) on Electrical and Mechanical Activities of Smooth Muscles of the Guinea-Pig Stomach

1984 ◽  
Vol 35 (3) ◽  
pp. 307-317 ◽  
Author(s):  
Kenichiro FURUKAWA ◽  
Yasusuke KIMOTO
Keyword(s):  
Guinea Pig ◽  
Smooth Muscles ◽  
Trimebutine Maleate ◽  
Guinea Pig Stomach ◽  
Electrical And Mechanical Activities

Muscarinic activity modulated by C-type natriuretic peptide in gastric smooth muscles of guinea-pig stomach

2007 ◽  
Vol 143 (1-3) ◽  
pp. 83-89 ◽  
Author(s):  
De-gang Xing ◽  
Xu Huang ◽  
Chun-hui Li ◽  
Xiang-lan Li ◽  
Lian-hua Piao ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Natriuretic Peptide ◽  
Smooth Muscles ◽  
Guinea Pig Stomach

scholarly journals Effects of Trimebutine Maleate (TM-906) on the Smooth Muscles of Isolated Guinea Pig Gallbladder

1984 ◽  
Vol 35 (4) ◽  
pp. 439-443 ◽  
Author(s):  
Hideyuki TAKENAGA ◽  
Tetsuo MAGARIBUCHI ◽  
Hajime TAMAKI
Keyword(s):  
Guinea Pig ◽  
Smooth Muscles ◽  
Trimebutine Maleate

Polydatin Attenuates Carbachol-induced Contraction of Guinea Pig Gallbladder

2019 ◽  
Vol 18 (1) ◽  
pp. 34-38
Author(s):  
Chen Lei ◽  
Pan Xiang ◽  
Shen Yonggang ◽  
Song Kai ◽  
Zhong Xingguo ◽  
...  
Keyword(s):  
Protein Kinase ◽  
Guinea Pig ◽  
Smooth Muscles ◽  
Cyclic Adenosine Monophosphate ◽  
Adenosine Monophosphate ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Dependent Manner ◽  
Underlying Mechanisms ◽  
Dose Dependent

The aim of this study was to determine whether polydatin, a glucoside of resveratrol isolated from the root of Polygonum cuspidatum, warranted development as a potential therapeutic for ameliorating the pain originating from gallbladder spasm disorders and the underlying mechanisms. Guinea pig gallbladder smooth muscles were treated with polydatin and specific inhibitors to explore the mechanisms underpinning polydatin-induced relaxation of carbachol-precontracted guinea pig gallbladder. Our results shown that polydatin relaxed carbachol-induced contraction in a dose-dependent manner through the nitric oxide/cyclic guanosine monophosphate/protein kinase G and the cyclic adenosine monophosphate/protein kinase A signaling pathways as well as the myosin light chain kinase and potassium channels. Our findings suggested that there was value in further exploring the potential therapeutic use of polydatin in gallbladder spasm disorders.

scholarly journals Regulation of acetylcholine release from the guinea-pig stomach via 5-HT4 receptors.

1994 ◽  
Vol 64 ◽  
pp. 90
Author(s):  
Shogo Matsuyama ◽  
Hideyo Sakjyama ◽  
Koji Nei ◽  
Shigenori Katayama ◽  
Norikazu Sakamoto ◽  
...  
Keyword(s):  
Guinea Pig ◽  
Acetylcholine Release ◽  
Guinea Pig Stomach
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