scholarly journals Comparative analysis of cell-free DNA content in culture medium and mitochondrial DNA copy number in porcine parthenogenetically activated embryos

2020 ◽  
Vol 66 (6) ◽  
pp. 539-546
Author(s):  
Mitsuru KOBAYASHI ◽  
Jun ITO ◽  
Koumei SHIRASUNA ◽  
Takehito KUWAYAMA ◽  
Hisataka IWATA
Keyword(s):  
Mitochondrial Dna ◽  
Comparative Analysis ◽  
Dna Content ◽  
Copy Number ◽  
Culture Medium ◽  
Dna Copy Number ◽  
Cell Free Dna ◽  
Free Dna ◽  
Mitochondrial Dna Copy Number

Effect of maternal aging and vitrification on mitochondrial DNA copy number in embryos and spent culture medium

2021 ◽  
Vol 21 (2) ◽  
pp. 100506
Author(s):  
Sogo Aoki ◽  
Jun Ito ◽  
Shunsuke Hara ◽  
Koumei Shirasuna ◽  
Hisataka Iwata
Keyword(s):  
Mitochondrial Dna ◽  
Copy Number ◽  
Culture Medium ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number ◽  
Maternal Aging

Prenatal exposure to bisphenol S and altered newborn mitochondrial DNA copy number in a baby cohort study: Sex-specific associations

Chemosphere ◽  
2021 ◽  
Vol 263 ◽  
pp. 128019
Author(s):  
Lulin Wang ◽  
Lulu Song ◽  
Bingqing Liu ◽  
Mingyang Wu ◽  
Yunyun Liu ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Cohort Study ◽  
Prenatal Exposure ◽  
Copy Number ◽  
Dna Copy Number ◽  
Bisphenol S ◽  
Mitochondrial Dna Copy Number

Reduced mitochondrial DNA copy number is correlated with tumor progression and prognosis in Chinese breast cancer patients

IUBMB Life ◽  
2007 ◽  
Vol 59 (7) ◽  
pp. 450-457 ◽  
Author(s):  
Man Yu ◽  
Yunli Zhou ◽  
Yurong Shi ◽  
Liansheng Ning ◽  
Yi Yang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Mitochondrial Dna ◽  
Tumor Progression ◽  
Cancer Patients ◽  
Copy Number ◽  
Breast Cancer Patients ◽  
Dna Copy Number ◽  
Mitochondrial Dna Copy Number

Abstract 751: Lung mitochondrial DNA copy number variations: E-cig users, smokers, and never-smokers

2021 ◽  
Author(s):  
Kellie M. Mori ◽  
Joseph P. McElroy ◽  
Daniel Y. Weng ◽  
Sangwoon Chung ◽  
Sarah A. Reisinger ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Copy Number ◽  
Copy Number Variations ◽  
Dna Copy Number ◽  
Dna Copy Number Variations ◽  
Mitochondrial Dna Copy Number ◽  
Never Smokers

Circulating Janus kinase family DNA levels in psoriasis: elevated JAK2 DNA copy number in cell‐free DNA

2021 ◽  
Author(s):  
Kayo Kashiwada‐Nakamura ◽  
Tselmeg Mijiddorj Myangat ◽  
Ikko Kajihara ◽  
Hisashi Kanemaru ◽  
Soichiro Sawamura ◽  
...  
Keyword(s):  
Copy Number ◽  
Janus Kinase ◽  
Dna Copy Number ◽  
Cell Free Dna ◽  
Free Dna ◽  
Kinase Family

Rare instances of non-random dropout with the monochrome multiplex qPCR assay for mitochondrial DNA copy number

2021 ◽  
Author(s):  
Stephanie Y Yang ◽  
Charles E Newcomb ◽  
Stephanie L Battle ◽  
Anthony YY Hsieh ◽  
Hailey L Chapman ◽  
...  
Keyword(s):  
Mitochondrial Dna ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Copy Number ◽  
Whole Genome Sequencing Data ◽  
Whole Genome ◽  
Dna Copy Number ◽  
Loop Primer ◽  
Mitochondrial Dna Copy Number ◽  
D Loop

Mitochondrial DNA copy number (mtDNA-CN) is a proxy for mitochondrial function and has been of increasing interest to the mitochondrial research community. There are several ways to measure mtDNA-CN, ranging from whole genome sequencing to qPCR. A recent article from the Journal of Molecular Diagnostics described a novel method for measuring mtDNA-CN that is both inexpensive and reproducible. However, we show that certain individuals, particularly those with very low qPCR mtDNA measurements, show poor concordance between qPCR and whole genome sequencing measurements. After examining whole genome sequencing data, this seems to be due to polymorphisms within the D-loop primer region. Non-concordant mtDNA-CN was observed in all instances of polymorphisms at certain positions in the D-loop primer regions, however, not all positions are susceptible to this effect. In particular, these polymorphisms appear disproportionately in individuals with the L, T, and U mitochondrial haplogroups, indicating non-random dropout.

Sign in / Sign up

Export Citation Format

Share Document