scholarly journals Reprogramming Bone Marrow Stem Cells to Functional Endothelial Cells in a Mini Pig Animal Model

2017 ◽  
Vol 23 ◽  
pp. 285-294 ◽  
Author(s):  
Franziska Schlegel ◽  
Marco Appler ◽  
Michelle Halling ◽  
Francis Edwin Smit ◽  
Friedrich-Wilhelm Mohr ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Animal Model ◽  
Endothelial Cells ◽  
Bone Marrow Stem Cells ◽  
Pig Animal Model

R095: Transplantation of Bone-Marrow Stem Cells in an Animal Model

2007 ◽  
Vol 137 (2_suppl) ◽  
pp. P183-P183
Author(s):  
Akihiro Matsuoka ◽  
Takako Kondo ◽  
Richard T Miyamoto ◽  
Eri Hashino
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Animal Model ◽  
Bone Marrow Stem Cells

Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle

2009 ◽  
Vol 210 (1-2) ◽  
pp. 40-51 ◽  
Author(s):  
Tapas K. Makar ◽  
Christopher T. Bever ◽  
Ishwar S. Singh ◽  
Walter Royal ◽  
Surasri Nandan Sahu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Bone Marrow ◽  
Animal Model ◽  
Gene Delivery ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bone Marrow Stem Cells ◽  
Factor Gene

scholarly journals VENTRICULAR ARRHYTHMIAS FOLLOWING INTRAMYOCARDIAL INJECTIONS OF BONE MARROW STEM CELLS: AN ANIMAL MODEL

2012 ◽  
Vol 59 (13) ◽  
pp. E631
Author(s):  
Anna Vittoria Mattioli ◽  
Roberto Lonardi ◽  
Sonia Pennella ◽  
Enrico Giuliani ◽  
Alberto Farinetti
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Animal Model ◽  
Ventricular Arrhythmias ◽  
Bone Marrow Stem Cells

scholarly journals Platelets Boost Recruitment of CD133+ Bone Marrow Stem Cells to Endothelium and the Rodent Liver—The Role of P-Selectin/PSGL-1 Interactions

2020 ◽  
Vol 21 (17) ◽  
pp. 6431
Author(s):  
Nadja Lehwald ◽  
Constanze Duhme ◽  
Iryna Pinchuk ◽  
Julian Kirchner ◽  
Kristina Wieferich ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Endothelial Cells ◽  
Warm Ischemia ◽  
Bone Marrow Stem Cells ◽  
Hepatic Regeneration ◽  
Human And Mouse ◽  
Injured Liver

We previously demonstrated that clinical administration of mobilized CD133+ bone marrow stem cells (BMSC) accelerates hepatic regeneration. Here, we investigated the potential of platelets to modulate CD133+BMSC homing to hepatic endothelial cells and sequestration to warm ischemic livers. Modulatory effects of platelets on the adhesion of CD133+BMSC to human and mouse liver-sinusoidal- and micro- endothelial cells (EC) respectively were evaluated in in vitro co-culture systems. CD133+BMSC adhesion to all types of EC were increased in the presence of platelets under shear stress. This platelet effect was mostly diminished by antagonization of P-selectin and its ligand P-Selectin-Glyco-Ligand-1 (PSGL-1). Inhibition of PECAM-1 as well as SDF-1 receptor CXCR4 had no such effect. In a model of the isolated reperfused rat liver subsequent to warm ischemia, the co-infusion of platelets augmented CD133+BMSC homing to the injured liver with heightened transmigration towards the extra sinusoidal space when compared to perfusion conditions without platelets. Extravascular co-localization of CD133+BMSC with hepatocytes was confirmed by confocal microscopy. We demonstrated an enhancing effect of platelets on CD133+BMSC homing to and transmigrating along hepatic EC putatively depending on PSGL-1 and P-selectin. Our insights suggest a new mechanism of platelets to augment stem cell dependent hepatic repair.

Bone marrow stem cells make hepatocytes with replicative potential

2001 ◽  
Vol 120 (5) ◽  
pp. A62-A62
Author(s):  
S FORBES ◽  
M ALISON ◽  
K HODIVALADILKE ◽  
R JEFFERY ◽  
R POULSOM ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Bone Marrow Stem Cells

Autologous 5-azacytidine-cultured bone-marrow stem cells in surgical treatment of heart failure

2008 ◽  
Vol 7 ◽  
pp. 114-115
Author(s):  
R AKCHURIN ◽  
T RAKHMATZADE ◽  
E SKRIDLEVSKAYA ◽  
L SAMOYLENKO ◽  
V SERGIENKO ◽  
...  
Keyword(s):  
Heart Failure ◽  
Stem Cells ◽  
Bone Marrow ◽  
Surgical Treatment ◽  
Bone Marrow Stem Cells
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