scholarly journals Recent advances in the management of priapism

F1000Research ◽  
2018 ◽  
Vol 7 ◽  
pp. 37 ◽  
Author(s):  
Asif Muneer ◽  
Hussain M. Alnajjar ◽  
David Ralph
Keyword(s):  
Erectile Dysfunction ◽  
Muscle Function ◽  
Penile Erection ◽  
Medical Intervention ◽  
Physiological Mechanisms ◽  
Sexual Stimulation ◽  
Ischemic Priapism ◽  
Smooth Muscle Function ◽  
Urological Emergency ◽  
Stuttering Priapism

Priapism is an uncommon urological emergency that can lead to permanent impotence if prompt presentation and medical intervention is not performed. It is a breakdown of the usual physiological mechanisms controlling penile tumescence and detumescence, leading to a prolonged penile erection (>4 hours) that is unrelated to sexual stimulation. Currently, there are three accepted subtypes: ischaemic, non-ischaemic, and stuttering priapism, which is also known as recurrent ischemic priapism. The aim of treatment is the immediate resolution of the painful erection and the preservation of cavernosal smooth muscle function in order to prevent cavernosal fibrosis, which can lead to penile shortening and permanent erectile dysfunction.

Priapism

2017 ◽  
Author(s):  
Asif Muneer ◽  
David Ralph
Keyword(s):  
Muscle Function ◽  
Arterial Embolization ◽  
The Other ◽  
Medical Emergency ◽  
Recreational Drug ◽  
Selective Arterial Embolization ◽  
Arterial Blood ◽  
Smooth Muscle Function ◽  
Recreational Drug Use ◽  
Stuttering Priapism

Priapism is rare and is a medical emergency. Ischaemic priapism is the commonest subtype with haematological abnormalities, psychotropic or recreational drug use and malignancy being the other common aetiologies. Emergency decompression of this compartment syndrome is required to preserve cavernosal smooth muscle function and this should ideally be performed as soon as possible. The degree of resultant erectile dysfunction is related to the duration of the priapism. Non-ischaemic priapism is an unregulated inflow of arterial blood, often as a result of perineal trauma and a lacerated cavernosal vessel. Selective arterial embolization should be performed and results are usually excellent. The final subtype is stuttering priapism, the cause of which is often unknown and a variety of methods will be discussed for its treatment.

scholarly journals Stuttering priapism post C-spine schwannoma excision: case report

2020 ◽  
Vol 7 (9) ◽  
pp. 3077
Author(s):  
Ngwobia Peter Agwu ◽  
Ali Lasseini
Keyword(s):  
Penile Erection ◽  
Relevant Literature ◽  
Surgical Excision ◽  
Early Postoperative Period ◽  
Rare Occurrence ◽  
Spine Tumor ◽  
Sexual Stimulation ◽  
Cervical Spine Tumor ◽  
Stuttering Priapism ◽  
Delayed Intervention

Priapism is prolonged penile erection that persists beyond or is unrelated to sexual stimulation and this is associated with significant psychological, socioeconomic and physical morbidity. It is a urologic emergency as delayed intervention may result in penile fibrosis and consequent erectile dysfunction. The aim of this paper is to present our experience in the management of the rare occurrence of stuttering priapism in a 32 years old man following surgical excision of cervical schwannoma during the early postoperative period and review relevant literature on management of this urologic entity. Stuttering priapism may complicate cervical spine tumor excision but may demonstrate complete patient recovery. 

scholarly journals EFEK APOMORFIN SUBLINGUAL PADA EREKSI PENIS

2013 ◽  
Vol 4 (3) ◽  
Author(s):  
Kaleb D.S. Salossa ◽  
Sonny J.R. Kalangi ◽  
Ghazaly Adam
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Erectile Dysfunction ◽  
Cardiovascular Diseases ◽  
Paraventricular Nucleus ◽  
Penile Erection ◽  
Sexual Stimulation ◽  
Psychosocial Therapy ◽  
Penile Erections ◽  
The Central Nervous System

Abstract: Erectile dysfunction is the disability of a male to maintain consistant or repeated penile erections sufficiently for successful sexual intercourse. Many efforts have been done to handle this condition, so far. The psychosocial therapy and several medications inter alia: testosterone, yohimbine, trazadone, direct intracavernosus injection of alprostadil, penile implantation, and  sildenafil citrate, are not always suitable for the patients’ needs, especiallly those who suffer from cardiovascular diseases. Therefore, a new erectogenic agent has been introduced, the sublingual apomorphine. This apomorphine has a dopamine-like molecule that acts on the dopamine receptors in the paraventricular nucleus (PVN) of the central nervous system to increase the penile erection due to sexual stimulation (erotic imagination, audiovisual, or tactile). The sublingual apomorphine has been proved effective in overcoming the erectile dysfunction, especially the mild and moderate forms. Keywords: penile erection, sublingual apomorphin.     Abstrak: Telah banyak upaya dilakukan untuk mengatasi disfungsi ereksi yang merupakan ketidakmampuan seorang laki-laki secara konsisten atau berulang untuk mencapai dan mempertahankan ereksi penis yang cukup untuk melakukan hubungan seksual. Terapi psikososial dan pengobatan yang pernah diajukan seperti pemberian hormon testosteron, yohimbin, trazadon, injeksi langsung alprostadil intrakavernosa, implantasi penis serta sildenafil sitrat tidaklah selalu sesuai dengan kebutuhan penderita, khususnya penderita disfungsi ereksi dengan penyakit kardiovaskuler. Para ahli berusaha melakukan terobosan baru salah satunya adalah apomorfin sublingual yang merupakan agen erektogenik baru. Apomorfin adalah suatu molekul mirip dopamin yang bekerja pada reseptor dopamin pada paraventricular nucleus (PVN) di sistem saraf pusat untuk meningkatkan rangsangan erektil saat stimulasi seksual (imaginasi erotik, audiovisual dan perabaan) terjadi. Apomorfin sublingual terbukti efektif untuk mengatasi disfungsi ereksi, terutama disfungsi ereksi ringan dan sedang. Kata kunci: ereksi penis, apomorfin sublingual.

ERECTION DISORDERS

2021 ◽  
Vol 3 (1) ◽  
Author(s):  
Țâr Horiana Emanuela
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Intercourse ◽  
Physiological Response ◽  
Penile Erection ◽  
Premature Ejaculation ◽  
Normal Activity ◽  
Medical Attention ◽  
Sexual Stimulation ◽  
Mental Stimulation ◽  
Sexual Tension

The first physiological response to effective sexual stimulation, produced by a source of physical or mental stimulation, is the erection of the penis. Erection usually occurs within 3-8 seconds of the onset of arousal. When sexual tension and erection reach a certain level in the presence of the partner, the need for interference appears. The intensity of the erection may increase or decrease until it disappears, whether the arousal is prolonged or not. The complicated anatomical apparatus is regulated by a nervous mechanism, just as complex, being dependent to a remarkable extent on psychic influences. By the strong interweaving of these two components - psychological and functional - the sexual function is subject to changes. Erectile dysfunction, when it occurs, is obvious because, although there may be libido, the lack of an erection makes it impossible to perform sexual intercourse. Erectile dysfunction should not be confused with isolated or occasional failures to obtain or maintain a penile erection. They do not constitute a condition or disease that justifies medical attention and should be perceived as absolutely normal. The vast majority of men face such an episode at some point in their lives. One can speak of erectile dysfunction in the case of a recurrent or persistent inability to obtain an erection or to maintain it long enough to complete sexual intercourse, which lasts at least three months. It is especially important because in a normal activity, without erection, intercourse, ejaculation and orgasm cannot take place. (Pathologically, premature ejaculation can occur, without an erection, in the form of pollution!)

scholarly journals Men with sickle cell disease experience greater sexual dysfunction when compared with men without sickle cell disease

2020 ◽  
Vol 4 (14) ◽  
pp. 3277-3283
Author(s):  
Ibrahim M. Idris ◽  
Akib Abba ◽  
Jamil A. Galadanci ◽  
Sharfuddeen A. Mashi ◽  
Nafiu Hussaini ◽  
...  
Keyword(s):  
Erectile Dysfunction ◽  
Sexual Dysfunction ◽  
Sickle Cell Disease ◽  
Sickle Cell ◽  
Medical Attention ◽  
Cell Disease ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Ischemic Priapism ◽  
Stuttering Priapism

Abstract Recurrent ischemic priapism is a common complication of sickle cell disease (SCD). We assessed the burden, characteristics, and types of priapism, including sexual dysfunction, in a cohort of men with and those without SCD, to test the hypothesis that sexual dysfunction is more prevalent in men with SCD. In Kano, Nigeria, we conducted a comparative cross-sectional survey that included 500 and 250 men 18 to 40 years of age, with and without SCD, respectively. The survey used the Priapism Questionnaire and the International Index of Erectile Function for sexual function assessment. All eligible participants approached for the study gave informed consent and were enrolled. Stuttering and major priapism were defined based on the average duration of priapism experiences that lasted ≤4 and >4 hours, respectively. The prevalence of priapism was significantly higher in men with SCD than in those without it (32.6% vs 2%; P < .001). Stuttering priapism accounted for 73.6% of the priapism episodes in men with SCD. Nearly 50% of the participants with SCD-related priapism had never sought medical attention for this complication. The majority of the men with SCD-related priapism used exercise as a coping mechanism. Priapism affected the self-image of the men with SCD, causing sadness, embarrassment, and fear. The percentage of the men with SCD who had erectile dysfunction was more than twofold higher than that of those without SCD who had erectile dysfunction (P = .01). The men with SCD had a higher prevalence of priapism and sexual dysfunction than the men without SCD.

SMALL BOWEL ISCHEMIA/REPERFUSION (II/R) ALTERS COLONIC SMOOTH MUSCLE FUNCTION.

Shock ◽  
1998 ◽  
Vol 9 (Supplement) ◽  
pp. 13
Author(s):  
DT Dempsey ◽  
BS Myers ◽  
JP Ryan ◽  
J Carroll ◽  
SI Myers
Keyword(s):  
Smooth Muscle ◽  
Small Bowel ◽  
Muscle Function ◽  
Ischemia Reperfusion ◽  
Bowel Ischemia ◽  
Smooth Muscle Function

Effect of Flush-Perfusion on Vascular Endothelial and Smooth Muscle Function

1997 ◽  
Vol 64 (4) ◽  
pp. 1075-1081 ◽  
Author(s):  
Richard Ingemansson ◽  
Algimantas Budrikis ◽  
Ramunas Bolys ◽  
Trygve Sjöberg ◽  
Stig Steen
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Vascular Endothelial ◽  
Smooth Muscle Function

scholarly journals Effects of Scleroderma Antibodies and Pooled Human Immunoglobulin on Anal Sphincter and Colonic Smooth Muscle Function

2012 ◽  
Vol 143 (5) ◽  
pp. 1308-1318 ◽  
Author(s):  
Jagmohan Singh ◽  
Sidney Cohen ◽  
Vaibhav Mehendiratta ◽  
Fabian Mendoza ◽  
Sergio A. Jimenez ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Anal Sphincter ◽  
Muscle Function ◽  
Human Immunoglobulin ◽  
Smooth Muscle Function

Abstract 212: Role of Monocytes and Inflammation in Vascular Endothelial Dysfunction in Mice With Heart Failure After Myocardial Infarction

2015 ◽  
Vol 35 (suppl_1) ◽  
Author(s):  
Michael Molitor ◽  
Stefanie Finger ◽  
Sabine Kossmann ◽  
Venkata S Garlapati ◽  
Jérémy Lagrange ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Muscle Function ◽  
Diphtheria Toxin ◽  
Vascular Dysfunction ◽  
Aortic Tissue ◽  
Vascular Endothelial ◽  
Smooth Muscle Function ◽  
Myelomonocytic Cells

Background: Heart failure (HF) after myocardial infarction (MI) leads to impaired left ventricular function and reduced blood flow in peripheral arteries. Angiotensin II (ATII) signaling is crucial in MI, and inflammatory myelomonocytic cells are involved in the process of ATII-induced vascular dysfunction. Their role in MI-mediated vascular dysfunction has not been defined yet. Objective: Test the impact of selective depletion of lysozyme M positive (LysM+) myelomonocytic cells on endothelial dysfunction in a model of ischemic heart failure in mice Methods and results: 8 to 12 week old mice (C57B6 background) were subjected to permanent coronary ligation of the left anterior descending artery (LAD) to induced HF post MI. We measured a reduced vascular endothelial and smooth muscle function in isolated aortic segments 7d and 28d post MI in isometric tension studies. Also the production of vascular superoxide (chemiluminescence, oxidative fluorescence microtopography) and vascular mRNA expression of MCP-1, VCAM-1, IL-6 and ATII receptor type 1 were increased (assessed by mRNA reverse transcription polymerase chain reaction) in HF mice compared to sham. FACS analysis of aortic tissue of HF mice shows an increased infiltration of CD45+ immune cells in the aortic wall, including CD11b+Gr-1lowF4/80+ monocytes/macrophages. Using mice with LysM dependent cre-inducible expression of diphtheria toxin receptor (LysMCreIDTR) we selectively ablated LysM+ myelomonocytic cells 28d after MI for 10d via diphtheria toxin. We assessed a significantly improved vascular endothelial and smooth muscle function, less vascular superoxide production and a reduced expression of VCAM-1 and ATII receptor type 1 in aortic tissue. The number of circulating monocytes in blood was reduced, while the cardiac function (EF (%), LV size) in sonography stays constant between depleted and non-depleted HF mice. Conclusion: Our results suggest that vascular dysfunction post MI is at least in part mediated by inflammatory leukocyte infiltrating the vessel wall and that depletion of inflammatory monocytes in HF after MI improves the vascular function. It can potentially be a new target to protect endothelial function in HF and prevent secondary events after a MI.

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