scholarly journals Antitumor Effect of Metformin in Combination with Binimetinib on Melanoma Cells

2021 ◽  
Vol 25 (2) ◽  
pp. 93-104
Author(s):  
Eunsung Lee ◽  
Yongjae Kwon ◽  
Jiwon Kim ◽  
Deokbae Park ◽  
Youngki Lee
Keyword(s):  
Antitumor Effect ◽  
Melanoma Cells

Antitumor effect of interleukin 7 in combination with local hyperthermia in mice bearing B16a melanoma cells

Stem Cells ◽  
1993 ◽  
Vol 11 (5) ◽  
pp. 412-421 ◽  
Author(s):  
Bo Wu ◽  
Rong‐Nian Shen ◽  
Wen‐Xue Wang ◽  
Hal E. Broxmeyer ◽  
Li Lu
Keyword(s):  
Antitumor Effect ◽  
Melanoma Cells ◽  
Local Hyperthermia ◽  
Interleukin 7

scholarly journals Antitumor Effect of c-myc Antisense Phosphorothioate Oligodeoxynucleotides on Human Melanoma Cells In Vitro and in Mice

1996 ◽  
Vol 88 (7) ◽  
pp. 419-429 ◽  
Author(s):  
Carlo Leonetti ◽  
Igea D' Agnano ◽  
Francesco Lozupone ◽  
Alessandra Valentini ◽  
Tim Geiser ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Melanoma Cells ◽  
Human Melanoma ◽  
Human Melanoma Cells ◽  
Phosphorothioate Oligodeoxynucleotides

Research on the antitumor effect of ginsenoside Rg3 in B16 melanoma cells

2008 ◽  
Vol 18 (5) ◽  
pp. 322-329 ◽  
Author(s):  
Junxia Chen ◽  
Huimin Peng ◽  
Xi Ou-Yang ◽  
Xiaoyan He
Keyword(s):  
Antitumor Effect ◽  
Melanoma Cells ◽  
B16 Melanoma ◽  
Ginsenoside Rg3 ◽  
B16 Melanoma Cells

Suppressor of cytokine signalling-1 induces significant preclinical antitumor effect in malignant melanoma cells

2015 ◽  
Vol 24 (11) ◽  
pp. 864-871 ◽  
Author(s):  
Naoko Tagami-Nagata ◽  
Satoshi Serada ◽  
Minoru Fujimoto ◽  
Atsushi Tanemura ◽  
Rie Nakatsuka ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Antitumor Effect ◽  
Melanoma Cells

Fluvastatin exerts an antitumor effect in vemurafenib-resistant melanoma cells

2019 ◽  
Vol 30 (5) ◽  
pp. 451-457 ◽  
Author(s):  
Masao Nishiya ◽  
Shinji Yasuhira ◽  
Masahiko Shibazaki ◽  
Hiroki Oikawa ◽  
Tomoyuki Masuda ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Melanoma Cells

scholarly journals Frugoside Induces Mitochondria-Mediated Apoptotic Cell Death through Inhibition of Sulfiredoxin Expression in Melanoma Cells

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 854 ◽  
Author(s):  
Song ◽  
Jeong ◽  
Kim ◽  
Shin ◽  
Jang
Keyword(s):  
Cell Death ◽  
Antitumor Effect ◽  
Apoptotic Cell ◽  
Bioactive Compound ◽  
Melanoma Cells ◽  
Therapeutic Agents ◽  
Human Melanoma ◽  
Oxygen Species ◽  
Therapeutic Implications ◽  
Life Threatening

Malignant melanoma is the most life-threatening neoplasm of the skin. Despite the increase in incidence, melanoma is becoming more resistant to current therapeutic agents. The bioactive compound frugoside has been recently reported to inhibit growth when used in various cancer cells. However, this effect has not been demonstrated in melanoma. Here, we found that frugoside inhibited the rate of reduction of hyperoxidized peroxiredoxins (Prxs) by downregulating sulfiredoxin (Srx) expression. Furthermore, frugoside increased the accumulation of sulfinic Prxs and reactive oxygen species (ROS) and stimulated p-p38 activation, resulting in the mitochondria-mediated death of M14 and A375 human melanoma cells. The mitochondria-mediated cell death induced by frugoside was inhibited by the overexpression of Srx and antioxidants, such as N-acetyl cysteine and diphenyleneiodonium. In addition, we observed that frugoside inhibited tumor growth without toxicity through a M14 xenograft animal model. Taken together, our findings reveal that frugoside exhibits a novel antitumor effect based on a ROS-mediated cell death in melanoma cells, which may have therapeutic implications.

A novel penicillin derivative induces antitumor effect in melanoma cells

2018 ◽  
Vol 29 (5) ◽  
pp. 416-428 ◽  
Author(s):  
Viviana Blank ◽  
Yanina Bellizzi ◽  
Elsa Zotta ◽  
Patricia G. Cornier ◽  
Carina M.L. Delpiccolo ◽  
...  
Keyword(s):  
Antitumor Effect ◽  
Melanoma Cells

scholarly journals Alpha-lipoic acid alters the antitumor effect of bortezomib in melanoma cells in vitro

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Angéla Takács ◽  
Eszter Lajkó ◽  
Orsolya Láng ◽  
Ildikó Istenes ◽  
László Kőhidai
Keyword(s):  
Lipoic Acid ◽  
Antitumor Effect ◽  
Melanoma Cells ◽  
Alpha Lipoic Acid
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