Objective: We aimed to study the predictive values of serum progesterone (P), human chorionic gonadotropin (HCG) and CA-125 for the pregnancy outcomes of threatened abortion complicated with subchorionic hematoma (SCH).
Materials and methods: Sixty women with threatened
abortion and SCH in 6-1 Oth gestational week, 60 with threatened abortion only and 60 healthy pregnant women were selected as groups A-C respectively. Levels of β-HCG, P, estradiol (E2) and CA-125 in peripheral venous blood were measured by chemiluminescence assay. Serum levels of INF-γ,
TNF-α, IL-2, IL-4 and IL-10 were detected by ELISA.
Results: Serum β-HCG, P, CA-125 and E2 levels of group A were significantly lower than those in group C (P<0.05). Groups A and B had significantly higher INF-y, TNF-a and IL-2 levels but lower IL-4 and IL-10 ones than
those of group C (P<0.05).The hospitalization and vaginal bleeding times of group A were significantly longer than those of groups B and C (P<0.05). The success rate of fetal protection, neonatal body weight and gestational age of groups A and B were significantly lower than those of
group C (P<0.05). Serum P, E2 and HCG levels were low in women with threatened abortion and SCH in early pregnancy, but CA-125 level was high, accompanied by increased INF-γ, TNF-α and IL-2 together with decreased IL-4 and IL-10.
Conclusion: The onset and progression
of SCH may be related to imbalance between T lymphocyte factors towards Th1 direction.
Predictive value of hyperglycosylated human chorionic gonadotropin for pregnancy outcomes in threatened abortion in first-trimester viable pregnancies