Associations between Maternal Exposure to Bisphenol A or Triclosan and Gestational Hypertension and Preeclampsia: The MIIREC Study

2018 ◽  
Vol 2018 (1) ◽  
Author(s):  
Louopou Rosalie Camara ◽  
Tye Arbuckle ◽  
Helen Trottier ◽  
William Fraser
Keyword(s):  
Bisphenol A ◽  
Gestational Hypertension ◽  
Maternal Exposure

scholarly journals Neuroendocrine and behavioral effects of maternal exposure to oral bisphenol A in female mice

2014 ◽  
Vol 220 (3) ◽  
pp. 375-388 ◽  
Author(s):  
Lydie Naulé ◽  
Marie Picot ◽  
Mariangela Martini ◽  
Caroline Parmentier ◽  
Hélène Hardin-Pouzet ◽  
...  
Keyword(s):  
Body Weight ◽  
Sexual Behavior ◽  
Bisphenol A ◽  
Preoptic Area ◽  
Third Ventricle ◽  
Daily Intake ◽  
Maternal Exposure ◽  
Developmental Exposure ◽  
Female Mice ◽  
Reference Doses

Bisphenol A (BPA) is a widespread estrogenic compound. We investigated the effects of maternal exposure to BPA at reference doses on sexual behavior and neuroendocrine functions of female offspring in C57BL/6J mice. The dams were orally exposed to vehicle alone or vehicle-containing BPA at doses equivalent to the no observed adverse effect level (5 mg/kg body weight per day) and tolerable daily intake (TDI, 0.05 mg/kg body weight per day) level from gestational day 15 until weaning. Developmental exposure to BPA increased the lordosis quotient in naive females exposed to BPA at the TDI dose only. BPA exposure had no effect on olfactory preference, ability to express masculine behaviors or number of calbindin-positive cells, a sexually dimorphic population of the preoptic area. BPA at both doses selectively increased kisspeptin cell number in the preoptic periventricular nucleus of the rostral periventricular area of the third ventricle in adult females. It did not affect the number of GNRH-positive cells or percentage of kisspeptin appositions on GNRH neurons in the preoptic area. These changes were associated with higher levels of estradiol (E2) at the TDI dose while levels of LH, estrus cyclicity, ovarian and uterine weights, and fertility remained unaffected. Delay in the time of vaginal opening was observed during the postnatal period at TDI dose, without any alteration in body growth. This shows that developmental exposure to BPA at reference doses did not masculinize and defeminize the neural circuitry underlying sexual behavior in female mice. The TDI dose specifically exacerbated responses normally induced by ovarian E2, through estrogen receptor α, during the postnatal/prepubertal period.

Maternal exposure to environmental bisphenol A impairs the neurons in hippocampus across generations

Toxicology ◽  
2020 ◽  
Vol 432 ◽  
pp. 152393 ◽  
Author(s):  
Haibin Zhang ◽  
Zhouyu Wang ◽  
Lingxue Meng ◽  
Hongxuan Kuang ◽  
Jian Liu ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Maternal Exposure

Simultaneous analysis of bisphenol A fractions in maternal and fetal compartments in early second trimester of pregnancy

2019 ◽  
Vol 47 (7) ◽  
pp. 765-770 ◽  
Author(s):  
Monika Zbucka-Krętowska ◽  
Urszula Łazarek ◽  
Wojciech Miltyk ◽  
Iwona Sidorkiewicz ◽  
Piotr Pierzyński ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Amniotic Fluid ◽  
Pregnant Women ◽  
Chromosomal Abnormalities ◽  
Maternal Plasma ◽  
Environmental Pollutant ◽  
Maternal Exposure ◽  
Gas Chromatography Mass Spectrometry ◽  
Permeability Factor ◽  
The Impact

Abstract Background Bisphenol A (BPA) is an estrogenic, endocrine-disrupting compound widely used in the industry. It is also a ubiquitous environmental pollutant. Its presence was confirmed in human fetuses, which results from maternal exposure during pregnancy. The mechanisms behind maternal-fetal transfer, and relationships between pregnant women and fetal exposures remain unclear. The aim of this study was to assess the impact of maternal exposure to BPA on the exposure of the fetus. Methods Maternal plasma and amniotic fluid samples were collected from 52 pregnant women undergoing amniocentesis for prenatal diagnosis of chromosomal abnormalities. BPA was measured by gas chromatography-mass spectrometry (GC-MS). The permeability factor – a ratio of fetal-to-maternal BPA concentration – was used as a measure delineating the transplacental transfer of BPA. Results The median concentration of maternal plasma BPA was 8 times higher than the total BPA concentration in the amniotic fluid (8.69 ng/mL, range: 4.3 ng/mL–55.3 ng/mL vs. median 1.03 ng/mL, range: 0.3 ng/mL–10.1 ng/mL). There was no direct relationship between the levels of BPA in maternal plasma and amniotic fluid levels. The permeability factor, in turn, negatively correlated with fetal development (birth weight) (R = −0.54, P < 0.001). Conclusion Our results suggest that the risk of fetal BPA exposure depends on placental BPA permeability rather than the levels of maternal BPA plasma concentration and support general recommendations to become aware and avoid BPA-containing products.

Changes in memory and synaptic plasticity induced in male rats after maternal exposure to bisphenol A

Toxicology ◽  
2014 ◽  
Vol 322 ◽  
pp. 51-60 ◽  
Author(s):  
Chong Wang ◽  
Ruiyan Niu ◽  
Yuchen Zhu ◽  
Haijun Han ◽  
Guangying Luo ◽  
...  
Keyword(s):  
Synaptic Plasticity ◽  
Bisphenol A ◽  
Maternal Exposure ◽  
Male Rats

scholarly journals Maternal exposure to bisphenol A and genistein has minimal effect on Avy/a offspring coat color but favors birth of agouti over nonagouti mice

2012 ◽  
Vol 110 (2) ◽  
pp. 537-542 ◽  
Author(s):  
C. S. Rosenfeld ◽  
P. T. Sieli ◽  
D. A. Warzak ◽  
M. R. Ellersieck ◽  
K. A. Pennington ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Coat Color ◽  
Maternal Exposure ◽  
Minimal Effect

Association of maternal exposure to bisphenol A with her β-hCG level and neonatal anthropometric measures

2021 ◽  
Author(s):  
Mohammad Mehdi Amin ◽  
Zahra Ghasemi ◽  
Mehri Khoshhali ◽  
Ensiyeh Taheri ◽  
Bahare Dehdashti ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Maternal Exposure ◽  
Anthropometric Measures ◽  
Β Hcg

Maternal exposure to low doses of bisphenol A affects learning and memory in male rat offspring with abnormal N-methyl-d-aspartate receptors in the hippocampus

2021 ◽  
pp. 074823372098462
Author(s):  
Chong Wang ◽  
Yao Shu ◽  
Li Xu ◽  
Qiling Liu ◽  
Bei Zhang ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Learning And Memory ◽  
Maternal Exposure ◽  
Male Offspring ◽  
Male Rat ◽  
Control Group ◽  
Sprague Dawley ◽  
Expression Levels ◽  
Rat Offspring ◽  
Sprague Dawley Rats

Bisphenol A (BPA), a component of polycarbonate and epoxy resins, has been reported to induce learning and memory deficits. However, the mechanisms have not been fully elucidated. Growing evidence has suggested that N-methyl-d-aspartate receptors (NMDARs) are involved in cognitive impairments. In this study, BPA was administered to female Sprague–Dawley rats (six per dose group) at concentrations of 0 (control), 4, 40, and 400 μg/kg·body weight/day from gestation day 1 through lactation day 21. Spatial learning was evaluated using the Morris water maze on postnatal day 22. Expression levels of NMDARs were determined using real-time polymerase chain reaction and Western blot. The results showed that male offspring exposed to BPA exhibited increased latency in reaching the platform and reduced time in the target quadrant, and the number of crossing the platform was less, as compared with the control group. The mRNA and protein expression levels of NMDARs in the hippocampus were significantly downregulated when compared with the control group of male offspring. The data showed that maternal exposure to BPA at low dosage can cause cognitive deficits in male rat offspring, probably due to a decrease in NMDARs in the hippocampus.

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